Glomerular matrix: synthesis, turnover and role in mesangial expansion.

J R Couchman; L A Beavan; K J McCarthy

Glomerular matrix: synthesis, turnover and role in mesangial expansion.

J R Couchman, L A Beavan, K J McCarthy

Nutritional Immunology

80 Citations (Scopus)

Abstract

The extracellular matrix has an integral role in development, homeostasis and pathology of the glomerulus. Three spatially distinct matrices are present in the glomerulus: the mesangium, and basement membranes of the capillary loops and Bowman's capsule. Each is dominated by basement membrane components, but is distinct in organization and composition. Many matrix components influence cell behavior directly, through specific interactions with receptors, or indirectly through growth factor sequestration. Growth factors may be of great importance in development and disease progression in the glomerulus, and may be central to mesangial expansion. In addition, changes in matrix composition accompany and contribute to the pathological condition, such as the accumulation of matrix in diabetes mellitus.

Original language	English
Journal	Kidney International
Volume	45
Issue number	2
Pages (from-to)	328-35
Number of pages	7
ISSN	0085-2538
Publication status	Published - 1994

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Cite this

@article{7e16c800597911dd8d9f000ea68e967b,

title = "Glomerular matrix: synthesis, turnover and role in mesangial expansion.",

abstract = "The extracellular matrix has an integral role in development, homeostasis and pathology of the glomerulus. Three spatially distinct matrices are present in the glomerulus: the mesangium, and basement membranes of the capillary loops and Bowman's capsule. Each is dominated by basement membrane components, but is distinct in organization and composition. Many matrix components influence cell behavior directly, through specific interactions with receptors, or indirectly through growth factor sequestration. Growth factors may be of great importance in development and disease progression in the glomerulus, and may be central to mesangial expansion. In addition, changes in matrix composition accompany and contribute to the pathological condition, such as the accumulation of matrix in diabetes mellitus.",

author = "Couchman, {J R} and Beavan, {L A} and McCarthy, {K J}",

note = "Keywords: Diabetes Mellitus; Extracellular Matrix; Extracellular Matrix Proteins; Fibronectins; Glomerular Mesangium; Humans; Kidney Glomerulus; Proteoglycans; Signal Transduction",

year = "1994",

language = "English",

volume = "45",

pages = "328--35",

journal = "Kidney International",

issn = "0085-2538",

publisher = "Elsevier",

number = "2",

}

TY - JOUR

T1 - Glomerular matrix: synthesis, turnover and role in mesangial expansion.

AU - Couchman, J R

AU - Beavan, L A

AU - McCarthy, K J

N1 - Keywords: Diabetes Mellitus; Extracellular Matrix; Extracellular Matrix Proteins; Fibronectins; Glomerular Mesangium; Humans; Kidney Glomerulus; Proteoglycans; Signal Transduction

PY - 1994

Y1 - 1994

N2 - The extracellular matrix has an integral role in development, homeostasis and pathology of the glomerulus. Three spatially distinct matrices are present in the glomerulus: the mesangium, and basement membranes of the capillary loops and Bowman's capsule. Each is dominated by basement membrane components, but is distinct in organization and composition. Many matrix components influence cell behavior directly, through specific interactions with receptors, or indirectly through growth factor sequestration. Growth factors may be of great importance in development and disease progression in the glomerulus, and may be central to mesangial expansion. In addition, changes in matrix composition accompany and contribute to the pathological condition, such as the accumulation of matrix in diabetes mellitus.

AB - The extracellular matrix has an integral role in development, homeostasis and pathology of the glomerulus. Three spatially distinct matrices are present in the glomerulus: the mesangium, and basement membranes of the capillary loops and Bowman's capsule. Each is dominated by basement membrane components, but is distinct in organization and composition. Many matrix components influence cell behavior directly, through specific interactions with receptors, or indirectly through growth factor sequestration. Growth factors may be of great importance in development and disease progression in the glomerulus, and may be central to mesangial expansion. In addition, changes in matrix composition accompany and contribute to the pathological condition, such as the accumulation of matrix in diabetes mellitus.

M3 - Journal article

C2 - 8164416

SN - 0085-2538

VL - 45

SP - 328

EP - 335

JO - Kidney International

JF - Kidney International

IS - 2

ER -

Glomerular matrix: synthesis, turnover and role in mesangial expansion.

Abstract

UN SDGs

Fingerprint

Cite this