TY - JOUR
T1 - Glomerular matrix: synthesis, turnover and role in mesangial expansion.
AU - Couchman, J R
AU - Beavan, L A
AU - McCarthy, K J
N1 - Keywords: Diabetes Mellitus; Extracellular Matrix; Extracellular Matrix Proteins; Fibronectins; Glomerular Mesangium; Humans; Kidney Glomerulus; Proteoglycans; Signal Transduction
PY - 1994
Y1 - 1994
N2 - The extracellular matrix has an integral role in development, homeostasis and pathology of the glomerulus. Three spatially distinct matrices are present in the glomerulus: the mesangium, and basement membranes of the capillary loops and Bowman's capsule. Each is dominated by basement membrane components, but is distinct in organization and composition. Many matrix components influence cell behavior directly, through specific interactions with receptors, or indirectly through growth factor sequestration. Growth factors may be of great importance in development and disease progression in the glomerulus, and may be central to mesangial expansion. In addition, changes in matrix composition accompany and contribute to the pathological condition, such as the accumulation of matrix in diabetes mellitus.
AB - The extracellular matrix has an integral role in development, homeostasis and pathology of the glomerulus. Three spatially distinct matrices are present in the glomerulus: the mesangium, and basement membranes of the capillary loops and Bowman's capsule. Each is dominated by basement membrane components, but is distinct in organization and composition. Many matrix components influence cell behavior directly, through specific interactions with receptors, or indirectly through growth factor sequestration. Growth factors may be of great importance in development and disease progression in the glomerulus, and may be central to mesangial expansion. In addition, changes in matrix composition accompany and contribute to the pathological condition, such as the accumulation of matrix in diabetes mellitus.
M3 - Journal article
C2 - 8164416
SN - 0085-2538
VL - 45
SP - 328
EP - 335
JO - Kidney International
JF - Kidney International
IS - 2
ER -
