Genotype-phenotype associations in obesity dependent on definition of the obesity phenotype

Sofia Inez Iqbal Kring; Lesli Hingstrup Larsen; Claus Holst; Søren Toubro; Torben Hansen; Arne Astrup; Oluf Pedersen; Thorkild I A Sørensen

doi:10.1159/000137665

Genotype-phenotype associations in obesity dependent on definition of the obesity phenotype

Sofia Inez Iqbal Kring, Lesli Hingstrup Larsen, Claus Holst, Søren Toubro, Torben Hansen, Arne Astrup, Oluf Pedersen, Thorkild I A Sørensen

35 Citations (Scopus)

Abstract

In previous studies of associations of variants in the genes UCP2, UCP3, PPARG2, CART, GRL, MC4R, MKKS, SHP, GHRL, and MCHR1 with obesity, we have used a case-control approach with cases defined by a threshold for BMI. In the present study, we assess the association of seven abdominal, peripheral, and overall obesity phenotypes, which were analyzed quantitatively, and thirteen candidate gene polymorphisms in these ten genes in the same cohort.

Original language	English
Journal	Obesity Facts
Volume	1
Issue number	3
Pages (from-to)	138-145
Number of pages	8
ISSN	1662-4025
DOIs	https://doi.org/10.1159/000137665
Publication status	Published - 2008

Keywords

Adult
Alleles
Body Fat Distribution
Body Mass Index
Case-Control Studies
Cohort Studies
Denmark
Follow-Up Studies
Genetic Association Studies
Humans
Ion Channels
Logistic Models
Male
Middle Aged
Mitochondrial Proteins
Obesity
Phenotype
Polymorphism, Genetic
Receptors, Cytoplasmic and Nuclear
Receptors, Somatostatin
Waist Circumference

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1159/000137665

Cite this

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title = "Genotype-phenotype associations in obesity dependent on definition of the obesity phenotype",

abstract = "In previous studies of associations of variants in the genes UCP2, UCP3, PPARG2, CART, GRL, MC4R, MKKS, SHP, GHRL, and MCHR1 with obesity, we have used a case-control approach with cases defined by a threshold for BMI. In the present study, we assess the association of seven abdominal, peripheral, and overall obesity phenotypes, which were analyzed quantitatively, and thirteen candidate gene polymorphisms in these ten genes in the same cohort.",

keywords = "Adult, Alleles, Body Fat Distribution, Body Mass Index, Case-Control Studies, Cohort Studies, Denmark, Follow-Up Studies, Genetic Association Studies, Humans, Ion Channels, Logistic Models, Male, Middle Aged, Mitochondrial Proteins, Obesity, Phenotype, Polymorphism, Genetic, Receptors, Cytoplasmic and Nuclear, Receptors, Somatostatin, Waist Circumference",

author = "Kring, {Sofia Inez Iqbal} and Larsen, {Lesli Hingstrup} and Claus Holst and S{\o}ren Toubro and Torben Hansen and Arne Astrup and Oluf Pedersen and S{\o}rensen, {Thorkild I A}",

year = "2008",

doi = "10.1159/000137665",

language = "English",

volume = "1",

pages = "138--145",

journal = "Obesity Facts",

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T1 - Genotype-phenotype associations in obesity dependent on definition of the obesity phenotype

AU - Kring, Sofia Inez Iqbal

AU - Larsen, Lesli Hingstrup

AU - Holst, Claus

AU - Toubro, Søren

AU - Hansen, Torben

AU - Astrup, Arne

AU - Pedersen, Oluf

AU - Sørensen, Thorkild I A

PY - 2008

Y1 - 2008

N2 - In previous studies of associations of variants in the genes UCP2, UCP3, PPARG2, CART, GRL, MC4R, MKKS, SHP, GHRL, and MCHR1 with obesity, we have used a case-control approach with cases defined by a threshold for BMI. In the present study, we assess the association of seven abdominal, peripheral, and overall obesity phenotypes, which were analyzed quantitatively, and thirteen candidate gene polymorphisms in these ten genes in the same cohort.

AB - In previous studies of associations of variants in the genes UCP2, UCP3, PPARG2, CART, GRL, MC4R, MKKS, SHP, GHRL, and MCHR1 with obesity, we have used a case-control approach with cases defined by a threshold for BMI. In the present study, we assess the association of seven abdominal, peripheral, and overall obesity phenotypes, which were analyzed quantitatively, and thirteen candidate gene polymorphisms in these ten genes in the same cohort.

KW - Adult

KW - Alleles

KW - Body Fat Distribution

KW - Body Mass Index

KW - Case-Control Studies

KW - Cohort Studies

KW - Denmark

KW - Follow-Up Studies

KW - Genetic Association Studies

KW - Humans

KW - Ion Channels

KW - Logistic Models

KW - Male

KW - Middle Aged

KW - Mitochondrial Proteins

KW - Obesity

KW - Phenotype

KW - Polymorphism, Genetic

KW - Receptors, Cytoplasmic and Nuclear

KW - Receptors, Somatostatin

KW - Waist Circumference

U2 - 10.1159/000137665

DO - 10.1159/000137665

M3 - Journal article

C2 - 20054173

SN - 1662-4025

VL - 1

SP - 138

EP - 145

JO - Obesity Facts

JF - Obesity Facts

IS - 3

ER -

Genotype-phenotype associations in obesity dependent on definition of the obesity phenotype

Abstract

Keywords

UN SDGs

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