Genome-wide association study of serum selenium concentrations

Jian Gong; Li Hsu; Tabitha Harrison; Irena B. King; Stefan Stürup; Xiaoling Song; David Duggan; Yan Liu; Carolyn Hutter; Stephen J. Chanock; Charles B. Eaton; James R. Marshall; Ulrike Peters

doi:10.3390/nu5051706

Genome-wide association study of serum selenium concentrations

Jian Gong, Li Hsu, Tabitha Harrison, Irena B. King, Stefan Stürup, Xiaoling Song, David Duggan, Yan Liu, Carolyn Hutter, Stephen J. Chanock, Charles B. Eaton, James R. Marshall, Ulrike Peters

6 Citations (Scopus)

Abstract

Selenium is an essential trace element and circulating selenium concentrations have been associated with a wide range of diseases. Candidate gene studies suggest that circulating selenium concentrations may be impacted by genetic variation; however, no study has comprehensively investigated this hypothesis. Therefore, we conducted a two-stage genome-wide association study to identify genetic variants associated with serum selenium concentrations in 1203 European descents from two cohorts: the Prostate, Lung, Colorectal, and Ovarian (PLCO) Cancer Screening and the Women's Health Initiative (WHI). We tested association between 2,474,333 single nucleotide polymorphisms (SNPs) and serum selenium concentrations using linear regression models. In the first stage (PLCO) 41 SNPs clustered in 15 regions had p < 1 × 10^-5. None of these 41 SNPs reached the significant threshold (p = 0.05/15 regions = 0.003) in the second stage (WHI). Three SNPs had p < 0.05 in the second stage (rs1395479 and rs1506807 in 4q34.3/AGA-NEIL3; and rs891684 in 17q24.3/SLC39A11) and had p between 2.62 × 10^-7 and 4.04 × 10^-7 in the combined analysis (PLCO + WHI). Additional studies are needed to replicate these findings. Identification of genetic variation that impacts selenium concentrations may contribute to a better understanding of which genes regulate circulating selenium concentrations.

Original language	English
Journal	Nutrients
Volume	5
Issue number	5
Pages (from-to)	1706-1718
Number of pages	12
ISSN	2072-6643
DOIs	https://doi.org/10.3390/nu5051706
Publication status	Published - 21 May 2013

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@article{a85d0a19288d46b99d0a089ff3e1b6ba,

title = "Genome-wide association study of serum selenium concentrations",

abstract = "Selenium is an essential trace element and circulating selenium concentrations have been associated with a wide range of diseases. Candidate gene studies suggest that circulating selenium concentrations may be impacted by genetic variation; however, no study has comprehensively investigated this hypothesis. Therefore, we conducted a two-stage genome-wide association study to identify genetic variants associated with serum selenium concentrations in 1203 European descents from two cohorts: the Prostate, Lung, Colorectal, and Ovarian (PLCO) Cancer Screening and the Women's Health Initiative (WHI). We tested association between 2,474,333 single nucleotide polymorphisms (SNPs) and serum selenium concentrations using linear regression models. In the first stage (PLCO) 41 SNPs clustered in 15 regions had p < 1 × 10-5. None of these 41 SNPs reached the significant threshold (p = 0.05/15 regions = 0.003) in the second stage (WHI). Three SNPs had p < 0.05 in the second stage (rs1395479 and rs1506807 in 4q34.3/AGA-NEIL3; and rs891684 in 17q24.3/SLC39A11) and had p between 2.62 × 10-7 and 4.04 × 10-7 in the combined analysis (PLCO + WHI). Additional studies are needed to replicate these findings. Identification of genetic variation that impacts selenium concentrations may contribute to a better understanding of which genes regulate circulating selenium concentrations.",

author = "Jian Gong and Li Hsu and Tabitha Harrison and {B. King}, Irena and Stefan St{\"u}rup and Xiaoling Song and David Duggan and Yan Liu and Carolyn Hutter and {J. Chanock}, Stephen and {B. Eaton}, Charles and {R. Marshall}, James and Ulrike Peters",

year = "2013",

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doi = "10.3390/nu5051706",

language = "English",

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T1 - Genome-wide association study of serum selenium concentrations

AU - Gong, Jian

AU - Hsu, Li

AU - Harrison, Tabitha

AU - B. King, Irena

AU - Stürup, Stefan

AU - Song, Xiaoling

AU - Duggan, David

AU - Liu, Yan

AU - Hutter, Carolyn

AU - J. Chanock, Stephen

AU - B. Eaton, Charles

AU - R. Marshall, James

AU - Peters, Ulrike

PY - 2013/5/21

Y1 - 2013/5/21

N2 - Selenium is an essential trace element and circulating selenium concentrations have been associated with a wide range of diseases. Candidate gene studies suggest that circulating selenium concentrations may be impacted by genetic variation; however, no study has comprehensively investigated this hypothesis. Therefore, we conducted a two-stage genome-wide association study to identify genetic variants associated with serum selenium concentrations in 1203 European descents from two cohorts: the Prostate, Lung, Colorectal, and Ovarian (PLCO) Cancer Screening and the Women's Health Initiative (WHI). We tested association between 2,474,333 single nucleotide polymorphisms (SNPs) and serum selenium concentrations using linear regression models. In the first stage (PLCO) 41 SNPs clustered in 15 regions had p < 1 × 10-5. None of these 41 SNPs reached the significant threshold (p = 0.05/15 regions = 0.003) in the second stage (WHI). Three SNPs had p < 0.05 in the second stage (rs1395479 and rs1506807 in 4q34.3/AGA-NEIL3; and rs891684 in 17q24.3/SLC39A11) and had p between 2.62 × 10-7 and 4.04 × 10-7 in the combined analysis (PLCO + WHI). Additional studies are needed to replicate these findings. Identification of genetic variation that impacts selenium concentrations may contribute to a better understanding of which genes regulate circulating selenium concentrations.

AB - Selenium is an essential trace element and circulating selenium concentrations have been associated with a wide range of diseases. Candidate gene studies suggest that circulating selenium concentrations may be impacted by genetic variation; however, no study has comprehensively investigated this hypothesis. Therefore, we conducted a two-stage genome-wide association study to identify genetic variants associated with serum selenium concentrations in 1203 European descents from two cohorts: the Prostate, Lung, Colorectal, and Ovarian (PLCO) Cancer Screening and the Women's Health Initiative (WHI). We tested association between 2,474,333 single nucleotide polymorphisms (SNPs) and serum selenium concentrations using linear regression models. In the first stage (PLCO) 41 SNPs clustered in 15 regions had p < 1 × 10-5. None of these 41 SNPs reached the significant threshold (p = 0.05/15 regions = 0.003) in the second stage (WHI). Three SNPs had p < 0.05 in the second stage (rs1395479 and rs1506807 in 4q34.3/AGA-NEIL3; and rs891684 in 17q24.3/SLC39A11) and had p between 2.62 × 10-7 and 4.04 × 10-7 in the combined analysis (PLCO + WHI). Additional studies are needed to replicate these findings. Identification of genetic variation that impacts selenium concentrations may contribute to a better understanding of which genes regulate circulating selenium concentrations.

U2 - 10.3390/nu5051706

DO - 10.3390/nu5051706

M3 - Journal article

C2 - 23698163

SN - 2072-6643

VL - 5

SP - 1706

EP - 1718

JO - Nutrients

JF - Nutrients

IS - 5

ER -

Genome-wide association study of serum selenium concentrations

Abstract

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