Abstract
Selenium is an essential trace element and circulating selenium concentrations have been associated with a wide range of diseases. Candidate gene studies suggest that circulating selenium concentrations may be impacted by genetic variation; however, no
study has comprehensively investigated this hypothesis. Therefore, we conducted a
two-stage genome-wide association study to identify genetic variants associated with
serum selenium concentrations in 1203 European descents from two cohorts: the
Prostate, Lung, Colorectal, and Ovarian (PLCO) Cancer Screening and the Women’s
Health Initiative (WHI). We tested association between 2,474,333 single nucleotide
polymorphisms (SNPs) and serum selenium concentrations using linear regression models.
In the first stage (PLCO) 41 SNPs clustered in 15 regions had p < 1 × 10−5. None of these
41 SNPs reached the significant threshold (p = 0.05/15 regions = 0.003) in the second stage
(WHI). Three SNPs had p < 0.05 in the second stage (rs1395479 and rs1506807 in
4q34.3/AGA-NEIL3; and rs891684 in 17q24.3/SLC39A11) and had p between 2.62 × 10−7
and 4.04 × 10−7 in the combined analysis (PLCO + WHI). Additional studies are needed to
replicate these findings. Identification of genetic variation that impacts selenium
concentrations may contribute to a better understanding of which genes regulate circulating
selenium concentrations.
study has comprehensively investigated this hypothesis. Therefore, we conducted a
two-stage genome-wide association study to identify genetic variants associated with
serum selenium concentrations in 1203 European descents from two cohorts: the
Prostate, Lung, Colorectal, and Ovarian (PLCO) Cancer Screening and the Women’s
Health Initiative (WHI). We tested association between 2,474,333 single nucleotide
polymorphisms (SNPs) and serum selenium concentrations using linear regression models.
In the first stage (PLCO) 41 SNPs clustered in 15 regions had p < 1 × 10−5. None of these
41 SNPs reached the significant threshold (p = 0.05/15 regions = 0.003) in the second stage
(WHI). Three SNPs had p < 0.05 in the second stage (rs1395479 and rs1506807 in
4q34.3/AGA-NEIL3; and rs891684 in 17q24.3/SLC39A11) and had p between 2.62 × 10−7
and 4.04 × 10−7 in the combined analysis (PLCO + WHI). Additional studies are needed to
replicate these findings. Identification of genetic variation that impacts selenium
concentrations may contribute to a better understanding of which genes regulate circulating
selenium concentrations.
| Originalsprog | Engelsk |
|---|---|
| Tidsskrift | Nutrients |
| Vol/bind | 5 |
| Udgave nummer | 5 |
| Sider (fra-til) | 1706-1718 |
| Antal sider | 12 |
| ISSN | 2072-6643 |
| DOI | |
| Status | Udgivet - 21 maj 2013 |
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