Genome-wide association studies of human adiposity: Zooming in on synapses.

Camilla H. Sandholt; Niels Grarup; Oluf Pedersen; Torben. Hansen

doi:10.1016/j.mce.2015.09.029

Genome-wide association studies of human adiposity: Zooming in on synapses.

Camilla H. Sandholt, Niels Grarup, Oluf Pedersen, Torben. Hansen

8 Citations (Scopus)

Abstract

The decade anniversary for genome-wide association studies (GWAS) is approaching, and this experimental approach has commenced a deeper understanding of the genetics underlying complex diseases. In obesity genetics the GIANT (Genetic Investigation of ANthropometric Traits) consortium has played a crucial role, recently with two comprehensive meta-analyses, one focusing on general obesity, analyzing body-mass index (BMI) and the other on fat distribution, focusing on waist-hip ratio adjusted for BMI. With the in silico methods applied in these two studies as the pivot, this review looks into some of the biological knowledge, beginning to emerge from the intricate genomic background behind the genetic determinants of human adiposity. These include synaptic dysfunction, where GWAS pinpoint potential new mechanisms in pathways already known to be linked with obesity.

Original language	English
Journal	Molecular and Cellular Endocrinology
Volume	418
Issue number	Part 2
Pages (from-to)	90-100
Number of pages	11
ISSN	0303-7207
DOIs	https://doi.org/10.1016/j.mce.2015.09.029
Publication status	Published - 15 Dec 2015

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10.1016/j.mce.2015.09.029

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title = "Genome-wide association studies of human adiposity: Zooming in on synapses.",

abstract = "The decade anniversary for genome-wide association studies (GWAS) is approaching, and this experimental approach has commenced a deeper understanding of the genetics underlying complex diseases. In obesity genetics the GIANT (Genetic Investigation of ANthropometric Traits) consortium has played a crucial role, recently with two comprehensive meta-analyses, one focusing on general obesity, analyzing body-mass index (BMI) and the other on fat distribution, focusing on waist-hip ratio adjusted for BMI. With the in silico methods applied in these two studies as the pivot, this review looks into some of the biological knowledge, beginning to emerge from the intricate genomic background behind the genetic determinants of human adiposity. These include synaptic dysfunction, where GWAS pinpoint potential new mechanisms in pathways already known to be linked with obesity.",

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AU - Hansen, Torben.

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AB - The decade anniversary for genome-wide association studies (GWAS) is approaching, and this experimental approach has commenced a deeper understanding of the genetics underlying complex diseases. In obesity genetics the GIANT (Genetic Investigation of ANthropometric Traits) consortium has played a crucial role, recently with two comprehensive meta-analyses, one focusing on general obesity, analyzing body-mass index (BMI) and the other on fat distribution, focusing on waist-hip ratio adjusted for BMI. With the in silico methods applied in these two studies as the pivot, this review looks into some of the biological knowledge, beginning to emerge from the intricate genomic background behind the genetic determinants of human adiposity. These include synaptic dysfunction, where GWAS pinpoint potential new mechanisms in pathways already known to be linked with obesity.

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JO - Molecular and Cellular Endocrinology

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Genome-wide association studies of human adiposity: Zooming in on synapses.

Abstract

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