Genome-wide association studies in the Japanese population identify seven novel loci for type 2 diabetes

Minako Imamura; Atsushi Takahashi; Toshimasa Yamauchi; Kazuo Hara; Kazuki Yasuda; Niels Grarup; Wei Zhao; Xu Wang; Alicia Huerta-Chagoya; Cheng Hu; Sanghoon Moon; Jirong Long; Soo Heon Kwak; Asif Rasheed; Richa Saxena; Ronald C W Ma; Yukinori Okada; Minoru Iwata; Jun Hosoe; Nobuhiro Shojima; Minaka Iwasaki; Hayato Fujita; Ken Suzuki; John Danesh; Torben Jørgensen; Marit E Jørgensen; Daniel R Witte; Ivan Brandslund; Cramer Christensen; Torben Hansen; Josep M Mercader; Jason Flannick; Hortensia Moreno-Macías; Noël P Burtt; Rong Zhang; Young Jin Kim; Wei Zheng; Jai Rup Singh; Claudia H T Tam; Hiroshi Hirose; Hiroshi Maegawa; Chikako Ito; Kohei Kaku; Hirotaka Watada; Yasushi Tanaka; Kazuyuki Tobe; Ryuzo Kawamori; Michiaki Kubo; Yoon Shin Cho; Juliana C N Chan; Dharambir Sanghera; Philippe Frossard; Kyong Soo Park; Xiao-Ou Shu; Bong-Jo Kim; Jose C Florez; Teresa Tusié-Luna; Weiping Jia; E Shyong Tai; Oluf Pedersen; Danish Saleheen; Shiro Maeda; Takashi Kadowaki

doi:10.1038/ncomms10531

Genome-wide association studies in the Japanese population identify seven novel loci for type 2 diabetes

Minako Imamura, Atsushi Takahashi, Toshimasa Yamauchi, Kazuo Hara, Kazuki Yasuda, Niels Grarup, Wei Zhao, Xu Wang, Alicia Huerta-Chagoya, Cheng Hu, Sanghoon Moon, Jirong Long, Soo Heon Kwak, Asif Rasheed, Richa Saxena, Ronald C W Ma, Yukinori Okada, Minoru Iwata, Jun Hosoe, Nobuhiro ShojimaMinaka Iwasaki, Hayato Fujita, Ken Suzuki, John Danesh, Torben Jørgensen, Marit E Jørgensen, Daniel R Witte, Ivan Brandslund, Cramer Christensen, Torben Hansen, Josep M Mercader, Jason Flannick, Hortensia Moreno-Macías, Noël P Burtt, Rong Zhang, Young Jin Kim, Wei Zheng, Jai Rup Singh, Claudia H T Tam, Hiroshi Hirose, Hiroshi Maegawa, Chikako Ito, Kohei Kaku, Hirotaka Watada, Yasushi Tanaka, Kazuyuki Tobe, Ryuzo Kawamori, Michiaki Kubo, Yoon Shin Cho, Juliana C N Chan, Dharambir Sanghera, Philippe Frossard, Kyong Soo Park, Xiao-Ou Shu, Bong-Jo Kim, Jose C Florez, Teresa Tusié-Luna, Weiping Jia, E Shyong Tai, Oluf Pedersen, Danish Saleheen, Shiro Maeda, Takashi Kadowaki

Department of Public Health

84 Citations (Scopus)

Abstract

Genome-wide association studies (GWAS) have identified more than 80 susceptibility loci for type 2 diabetes (T2D), but most of its heritability still remains to be elucidated. In this study, we conducted a meta-analysis of GWAS for T2D in the Japanese population. Combined data from discovery and subsequent validation analyses (23,399 T2D cases and 31,722 controls) identify 7 new loci with genome-wide significance (P<5 × 10^-8), rs1116357 near CCDC85A, rs147538848 in FAM60A, rs1575972 near DMRTA1, rs9309245 near ASB3, rs67156297 near ATP8B2, rs7107784 near MIR4686 and rs67839313 near INAFM2. Of these, the association of 4 loci with T2D is replicated in multi-ethnic populations other than Japanese (up to 65,936 T2Ds and 158,030 controls, P<0.007). These results indicate that expansion of single ethnic GWAS is still useful to identify novel susceptibility loci to complex traits not only for ethnicity-specific loci but also for common loci across different ethnicities.

Original language	English
Article number	10531
Journal	Nature Communications
Volume	7
Number of pages	12
ISSN	2041-1723
DOIs	https://doi.org/10.1038/ncomms10531
Publication status	Published - 28 Jan 2016

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Imamura, M., Takahashi, A., Yamauchi, T., Hara, K., Yasuda, K., Grarup, N., Zhao, W., Wang, X., Huerta-Chagoya, A., Hu, C., Moon, S., Long, J., Kwak, S. H., Rasheed, A., Saxena, R., Ma, R. C. W., Okada, Y., Iwata, M., Hosoe, J., ... Kadowaki, T. (2016). Genome-wide association studies in the Japanese population identify seven novel loci for type 2 diabetes. Nature Communications, 7, [10531]. https://doi.org/10.1038/ncomms10531

Imamura, M, Takahashi, A, Yamauchi, T, Hara, K, Yasuda, K, Grarup, N, Zhao, W, Wang, X, Huerta-Chagoya, A, Hu, C, Moon, S, Long, J, Kwak, SH, Rasheed, A, Saxena, R, Ma, RCW, Okada, Y, Iwata, M, Hosoe, J, Shojima, N, Iwasaki, M, Fujita, H, Suzuki, K, Danesh, J, Jørgensen, T, Jørgensen, ME, Witte, DR, Brandslund, I, Christensen, C, Hansen, T, Mercader, JM, Flannick, J, Moreno-Macías, H, Burtt, NP, Zhang, R, Kim, YJ, Zheng, W, Singh, JR, Tam, CHT, Hirose, H, Maegawa, H, Ito, C, Kaku, K, Watada, H, Tanaka, Y, Tobe, K, Kawamori, R, Kubo, M, Cho, YS, Chan, JCN, Sanghera, D, Frossard, P, Park, KS, Shu, X-O, Kim, B-J, Florez, JC, Tusié-Luna, T, Jia, W, Tai, ES, Pedersen, O, Saleheen, D, Maeda, S & Kadowaki, T 2016, 'Genome-wide association studies in the Japanese population identify seven novel loci for type 2 diabetes', Nature Communications, vol. 7, 10531. https://doi.org/10.1038/ncomms10531

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title = "Genome-wide association studies in the Japanese population identify seven novel loci for type 2 diabetes",

abstract = "Genome-wide association studies (GWAS) have identified more than 80 susceptibility loci for type 2 diabetes (T2D), but most of its heritability still remains to be elucidated. In this study, we conducted a meta-analysis of GWAS for T2D in the Japanese population. Combined data from discovery and subsequent validation analyses (23,399 T2D cases and 31,722 controls) identify 7 new loci with genome-wide significance (P<5 × 10-8), rs1116357 near CCDC85A, rs147538848 in FAM60A, rs1575972 near DMRTA1, rs9309245 near ASB3, rs67156297 near ATP8B2, rs7107784 near MIR4686 and rs67839313 near INAFM2. Of these, the association of 4 loci with T2D is replicated in multi-ethnic populations other than Japanese (up to 65,936 T2Ds and 158,030 controls, P<0.007). These results indicate that expansion of single ethnic GWAS is still useful to identify novel susceptibility loci to complex traits not only for ethnicity-specific loci but also for common loci across different ethnicities.",

author = "Minako Imamura and Atsushi Takahashi and Toshimasa Yamauchi and Kazuo Hara and Kazuki Yasuda and Niels Grarup and Wei Zhao and Xu Wang and Alicia Huerta-Chagoya and Cheng Hu and Sanghoon Moon and Jirong Long and Kwak, {Soo Heon} and Asif Rasheed and Richa Saxena and Ma, {Ronald C W} and Yukinori Okada and Minoru Iwata and Jun Hosoe and Nobuhiro Shojima and Minaka Iwasaki and Hayato Fujita and Ken Suzuki and John Danesh and Torben J{\o}rgensen and J{\o}rgensen, {Marit E} and Witte, {Daniel R} and Ivan Brandslund and Cramer Christensen and Torben Hansen and Mercader, {Josep M} and Jason Flannick and Hortensia Moreno-Mac{\'i}as and Burtt, {No{\"e}l P} and Rong Zhang and Kim, {Young Jin} and Wei Zheng and Singh, {Jai Rup} and Tam, {Claudia H T} and Hiroshi Hirose and Hiroshi Maegawa and Chikako Ito and Kohei Kaku and Hirotaka Watada and Yasushi Tanaka and Kazuyuki Tobe and Ryuzo Kawamori and Michiaki Kubo and Cho, {Yoon Shin} and Chan, {Juliana C N} and Dharambir Sanghera and Philippe Frossard and Park, {Kyong Soo} and Xiao-Ou Shu and Bong-Jo Kim and Florez, {Jose C} and Teresa Tusi{\'e}-Luna and Weiping Jia and Tai, {E Shyong} and Oluf Pedersen and Danish Saleheen and Shiro Maeda and Takashi Kadowaki",

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T1 - Genome-wide association studies in the Japanese population identify seven novel loci for type 2 diabetes

AU - Imamura, Minako

AU - Takahashi, Atsushi

AU - Yamauchi, Toshimasa

AU - Hara, Kazuo

AU - Yasuda, Kazuki

AU - Grarup, Niels

AU - Zhao, Wei

AU - Wang, Xu

AU - Huerta-Chagoya, Alicia

AU - Hu, Cheng

AU - Moon, Sanghoon

AU - Long, Jirong

AU - Kwak, Soo Heon

AU - Rasheed, Asif

AU - Saxena, Richa

AU - Ma, Ronald C W

AU - Okada, Yukinori

AU - Iwata, Minoru

AU - Hosoe, Jun

AU - Shojima, Nobuhiro

AU - Iwasaki, Minaka

AU - Fujita, Hayato

AU - Suzuki, Ken

AU - Danesh, John

AU - Jørgensen, Torben

AU - Jørgensen, Marit E

AU - Witte, Daniel R

AU - Brandslund, Ivan

AU - Christensen, Cramer

AU - Hansen, Torben

AU - Mercader, Josep M

AU - Flannick, Jason

AU - Moreno-Macías, Hortensia

AU - Burtt, Noël P

AU - Zhang, Rong

AU - Kim, Young Jin

AU - Zheng, Wei

AU - Singh, Jai Rup

AU - Tam, Claudia H T

AU - Hirose, Hiroshi

AU - Maegawa, Hiroshi

AU - Ito, Chikako

AU - Kaku, Kohei

AU - Watada, Hirotaka

AU - Tanaka, Yasushi

AU - Tobe, Kazuyuki

AU - Kawamori, Ryuzo

AU - Kubo, Michiaki

AU - Cho, Yoon Shin

AU - Chan, Juliana C N

AU - Sanghera, Dharambir

AU - Frossard, Philippe

AU - Park, Kyong Soo

AU - Shu, Xiao-Ou

AU - Kim, Bong-Jo

AU - Florez, Jose C

AU - Tusié-Luna, Teresa

AU - Jia, Weiping

AU - Tai, E Shyong

AU - Pedersen, Oluf

AU - Saleheen, Danish

AU - Maeda, Shiro

AU - Kadowaki, Takashi

PY - 2016/1/28

Y1 - 2016/1/28

N2 - Genome-wide association studies (GWAS) have identified more than 80 susceptibility loci for type 2 diabetes (T2D), but most of its heritability still remains to be elucidated. In this study, we conducted a meta-analysis of GWAS for T2D in the Japanese population. Combined data from discovery and subsequent validation analyses (23,399 T2D cases and 31,722 controls) identify 7 new loci with genome-wide significance (P<5 × 10-8), rs1116357 near CCDC85A, rs147538848 in FAM60A, rs1575972 near DMRTA1, rs9309245 near ASB3, rs67156297 near ATP8B2, rs7107784 near MIR4686 and rs67839313 near INAFM2. Of these, the association of 4 loci with T2D is replicated in multi-ethnic populations other than Japanese (up to 65,936 T2Ds and 158,030 controls, P<0.007). These results indicate that expansion of single ethnic GWAS is still useful to identify novel susceptibility loci to complex traits not only for ethnicity-specific loci but also for common loci across different ethnicities.

AB - Genome-wide association studies (GWAS) have identified more than 80 susceptibility loci for type 2 diabetes (T2D), but most of its heritability still remains to be elucidated. In this study, we conducted a meta-analysis of GWAS for T2D in the Japanese population. Combined data from discovery and subsequent validation analyses (23,399 T2D cases and 31,722 controls) identify 7 new loci with genome-wide significance (P<5 × 10-8), rs1116357 near CCDC85A, rs147538848 in FAM60A, rs1575972 near DMRTA1, rs9309245 near ASB3, rs67156297 near ATP8B2, rs7107784 near MIR4686 and rs67839313 near INAFM2. Of these, the association of 4 loci with T2D is replicated in multi-ethnic populations other than Japanese (up to 65,936 T2Ds and 158,030 controls, P<0.007). These results indicate that expansion of single ethnic GWAS is still useful to identify novel susceptibility loci to complex traits not only for ethnicity-specific loci but also for common loci across different ethnicities.

U2 - 10.1038/ncomms10531

DO - 10.1038/ncomms10531

M3 - Journal article

C2 - 26818947

SN - 2041-1723

VL - 7

JO - Nature Communications

JF - Nature Communications

M1 - 10531

ER -

Genome-wide association studies in the Japanese population identify seven novel loci for type 2 diabetes

Abstract

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