Genome sequencing reveals insights into physiology and longevity of the naked mole rat

Eun Bae Kim; Xiaodong Fang; Alexey A Fushan; Zhiyong Huang; Alexei V Lobanov; Lijuan Han; Stefano M Marino; Xiaoqing Sun; Anton A Turanov; Pengcheng Yang; Sun Hee Yim; Xiang Zhao; Marina V Kasaikina; Nina Stoletzki; Chunfang Peng; Paz Polak; Zhiqiang Xiong; Adam Kiezun; Yabing Zhu; Yuanxin Chen; Gregory V Kryukov; Qiang Zhang; Leonid Peshkin; Lan Yang; Roderick T Bronson; Rochelle Buffenstein; Bo Wang; Changlei Han; Qiye Li; Li Chen; Wei Zhao; Shamil R Sunyaev; Thomas J Park; Guojie Zhang; Jun Wang; Vadim N Gladyshev

doi:10.1038/nature10533

Genome sequencing reveals insights into physiology and longevity of the naked mole rat

Eun Bae Kim, Xiaodong Fang, Alexey A Fushan, Zhiyong Huang, Alexei V Lobanov, Lijuan Han, Stefano M Marino, Xiaoqing Sun, Anton A Turanov, Pengcheng Yang, Sun Hee Yim, Xiang Zhao, Marina V Kasaikina, Nina Stoletzki, Chunfang Peng, Paz Polak, Zhiqiang Xiong, Adam Kiezun, Yabing Zhu, Yuanxin ChenGregory V Kryukov, Qiang Zhang, Leonid Peshkin, Lan Yang, Roderick T Bronson, Rochelle Buffenstein, Bo Wang, Changlei Han, Qiye Li, Li Chen, Wei Zhao, Shamil R Sunyaev, Thomas J Park, Guojie Zhang, Jun Wang, Vadim N Gladyshev

Ecology and Evolution

353 Citations (Scopus)

Abstract

The naked mole rat (Heterocephalus glaber) is a strictly subterranean, extraordinarily long-lived eusocial mammal. Although it is the size of a mouse, its maximum lifespan exceeds 30 years, making this animal the longest-living rodent. Naked mole rats show negligible senescence, no age-related increase in mortality, and high fecundity until death. In addition to delayed ageing, they are resistant to both spontaneous cancer and experimentally induced tumorigenesis. Naked mole rats pose a challenge to the theories that link ageing, cancer and redox homeostasis. Although characterized by significant oxidative stress, the naked mole rat proteome does not show age-related susceptibility to oxidative damage or increased ubiquitination. Naked mole rats naturally reside in large colonies with a single breeding female, the 'queen', who suppresses the sexual maturity of her subordinates. They also live in full darkness, at low oxygen and high carbon dioxide concentrations, and are unable to sustain thermogenesis nor feel certain types of pain. Here we report the sequencing and analysis of the naked mole rat genome, which reveals unique genome features and molecular adaptations consistent with cancer resistance, poikilothermy, hairlessness and insensitivity to low oxygen, and altered visual function, circadian rythms and taste sensing. This information provides insights into the naked mole rat's exceptional longevity and ability to live in hostile conditions, in the dark and at low oxygen. The extreme traits of the naked mole rat, together with the reported genome and transcriptome information, offer opportunities for understanding ageing and advancing other areas of biological and biomedical research.

Original language	English
Journal	Nature Photographer
Volume	479
Issue number	7372
Pages (from-to)	223-7
Number of pages	5
ISSN	1049-6602
DOIs	https://doi.org/10.1038/nature10533
Publication status	Published - 10 Nov 2011

Keywords

Adaptation, Physiological
Aging
Amino Acid Sequence
Animals
Body Temperature Regulation
Carbon Dioxide
Circadian Rhythm
Darkness
Genes
Genome
Genomic Instability
Genomics
Humans
Ion Channels
Longevity
Male
Mitochondrial Proteins
Mole Rats
Molecular Sequence Data
Mutagenesis
Oxygen
Taste
Transcriptome
Visual Perception

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1038/nature10533

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Kim, E. B., Fang, X., Fushan, A. A., Huang, Z., Lobanov, A. V., Han, L., Marino, S. M., Sun, X., Turanov, A. A., Yang, P., Yim, S. H., Zhao, X., Kasaikina, M. V., Stoletzki, N., Peng, C., Polak, P., Xiong, Z., Kiezun, A., Zhu, Y., ... Gladyshev, V. N. (2011). Genome sequencing reveals insights into physiology and longevity of the naked mole rat. Nature Photographer, 479(7372), 223-7. https://doi.org/10.1038/nature10533

Kim, EB, Fang, X, Fushan, AA, Huang, Z, Lobanov, AV, Han, L, Marino, SM, Sun, X, Turanov, AA, Yang, P, Yim, SH, Zhao, X, Kasaikina, MV, Stoletzki, N, Peng, C, Polak, P, Xiong, Z, Kiezun, A, Zhu, Y, Chen, Y, Kryukov, GV, Zhang, Q, Peshkin, L, Yang, L, Bronson, RT, Buffenstein, R, Wang, B, Han, C, Li, Q, Chen, L, Zhao, W, Sunyaev, SR, Park, TJ, Zhang, G, Wang, J & Gladyshev, VN 2011, 'Genome sequencing reveals insights into physiology and longevity of the naked mole rat', Nature Photographer, vol. 479, no. 7372, pp. 223-7. https://doi.org/10.1038/nature10533

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title = "Genome sequencing reveals insights into physiology and longevity of the naked mole rat",

abstract = "The naked mole rat (Heterocephalus glaber) is a strictly subterranean, extraordinarily long-lived eusocial mammal. Although it is the size of a mouse, its maximum lifespan exceeds 30 years, making this animal the longest-living rodent. Naked mole rats show negligible senescence, no age-related increase in mortality, and high fecundity until death. In addition to delayed ageing, they are resistant to both spontaneous cancer and experimentally induced tumorigenesis. Naked mole rats pose a challenge to the theories that link ageing, cancer and redox homeostasis. Although characterized by significant oxidative stress, the naked mole rat proteome does not show age-related susceptibility to oxidative damage or increased ubiquitination. Naked mole rats naturally reside in large colonies with a single breeding female, the 'queen', who suppresses the sexual maturity of her subordinates. They also live in full darkness, at low oxygen and high carbon dioxide concentrations, and are unable to sustain thermogenesis nor feel certain types of pain. Here we report the sequencing and analysis of the naked mole rat genome, which reveals unique genome features and molecular adaptations consistent with cancer resistance, poikilothermy, hairlessness and insensitivity to low oxygen, and altered visual function, circadian rythms and taste sensing. This information provides insights into the naked mole rat's exceptional longevity and ability to live in hostile conditions, in the dark and at low oxygen. The extreme traits of the naked mole rat, together with the reported genome and transcriptome information, offer opportunities for understanding ageing and advancing other areas of biological and biomedical research.",

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AU - Fang, Xiaodong

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AU - Lobanov, Alexei V

AU - Han, Lijuan

AU - Marino, Stefano M

AU - Sun, Xiaoqing

AU - Turanov, Anton A

AU - Yang, Pengcheng

AU - Yim, Sun Hee

AU - Zhao, Xiang

AU - Kasaikina, Marina V

AU - Stoletzki, Nina

AU - Peng, Chunfang

AU - Polak, Paz

AU - Xiong, Zhiqiang

AU - Kiezun, Adam

AU - Zhu, Yabing

AU - Chen, Yuanxin

AU - Kryukov, Gregory V

AU - Zhang, Qiang

AU - Peshkin, Leonid

AU - Yang, Lan

AU - Bronson, Roderick T

AU - Buffenstein, Rochelle

AU - Wang, Bo

AU - Han, Changlei

AU - Li, Qiye

AU - Chen, Li

AU - Zhao, Wei

AU - Sunyaev, Shamil R

AU - Park, Thomas J

AU - Zhang, Guojie

AU - Wang, Jun

AU - Gladyshev, Vadim N

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N2 - The naked mole rat (Heterocephalus glaber) is a strictly subterranean, extraordinarily long-lived eusocial mammal. Although it is the size of a mouse, its maximum lifespan exceeds 30 years, making this animal the longest-living rodent. Naked mole rats show negligible senescence, no age-related increase in mortality, and high fecundity until death. In addition to delayed ageing, they are resistant to both spontaneous cancer and experimentally induced tumorigenesis. Naked mole rats pose a challenge to the theories that link ageing, cancer and redox homeostasis. Although characterized by significant oxidative stress, the naked mole rat proteome does not show age-related susceptibility to oxidative damage or increased ubiquitination. Naked mole rats naturally reside in large colonies with a single breeding female, the 'queen', who suppresses the sexual maturity of her subordinates. They also live in full darkness, at low oxygen and high carbon dioxide concentrations, and are unable to sustain thermogenesis nor feel certain types of pain. Here we report the sequencing and analysis of the naked mole rat genome, which reveals unique genome features and molecular adaptations consistent with cancer resistance, poikilothermy, hairlessness and insensitivity to low oxygen, and altered visual function, circadian rythms and taste sensing. This information provides insights into the naked mole rat's exceptional longevity and ability to live in hostile conditions, in the dark and at low oxygen. The extreme traits of the naked mole rat, together with the reported genome and transcriptome information, offer opportunities for understanding ageing and advancing other areas of biological and biomedical research.

AB - The naked mole rat (Heterocephalus glaber) is a strictly subterranean, extraordinarily long-lived eusocial mammal. Although it is the size of a mouse, its maximum lifespan exceeds 30 years, making this animal the longest-living rodent. Naked mole rats show negligible senescence, no age-related increase in mortality, and high fecundity until death. In addition to delayed ageing, they are resistant to both spontaneous cancer and experimentally induced tumorigenesis. Naked mole rats pose a challenge to the theories that link ageing, cancer and redox homeostasis. Although characterized by significant oxidative stress, the naked mole rat proteome does not show age-related susceptibility to oxidative damage or increased ubiquitination. Naked mole rats naturally reside in large colonies with a single breeding female, the 'queen', who suppresses the sexual maturity of her subordinates. They also live in full darkness, at low oxygen and high carbon dioxide concentrations, and are unable to sustain thermogenesis nor feel certain types of pain. Here we report the sequencing and analysis of the naked mole rat genome, which reveals unique genome features and molecular adaptations consistent with cancer resistance, poikilothermy, hairlessness and insensitivity to low oxygen, and altered visual function, circadian rythms and taste sensing. This information provides insights into the naked mole rat's exceptional longevity and ability to live in hostile conditions, in the dark and at low oxygen. The extreme traits of the naked mole rat, together with the reported genome and transcriptome information, offer opportunities for understanding ageing and advancing other areas of biological and biomedical research.

KW - Adaptation, Physiological

KW - Aging

KW - Amino Acid Sequence

KW - Animals

KW - Body Temperature Regulation

KW - Carbon Dioxide

KW - Circadian Rhythm

KW - Darkness

KW - Genes

KW - Genome

KW - Genomic Instability

KW - Genomics

KW - Humans

KW - Ion Channels

KW - Longevity

KW - Male

KW - Mitochondrial Proteins

KW - Mole Rats

KW - Molecular Sequence Data

KW - Mutagenesis

KW - Oxygen

KW - Taste

KW - Transcriptome

KW - Visual Perception

U2 - 10.1038/nature10533

DO - 10.1038/nature10533

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C2 - 21993625

SN - 1049-6602

VL - 479

SP - 223

EP - 227

JO - Nature Photographer

JF - Nature Photographer

IS - 7372

ER -

Genome sequencing reveals insights into physiology and longevity of the naked mole rat

Abstract

Keywords

UN SDGs

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