Genome sequencing reveals insights into physiology and longevity of the naked mole rat

Eun Bae Kim; Xiaodong Fang; Alexey A Fushan; Zhiyong Huang; Alexei V Lobanov; Lijuan Han; Stefano M Marino; Xiaoqing Sun; Anton A Turanov; Pengcheng Yang; Sun Hee Yim; Xiang Zhao; Marina V Kasaikina; Nina Stoletzki; Chunfang Peng; Paz Polak; Zhiqiang Xiong; Adam Kiezun; Yabing Zhu; Yuanxin Chen; Gregory V Kryukov; Qiang Zhang; Leonid Peshkin; Lan Yang; Roderick T Bronson; Rochelle Buffenstein; Bo Wang; Changlei Han; Qiye Li; Li Chen; Wei Zhao; Shamil R Sunyaev; Thomas J Park; Guojie Zhang; Jun Wang; Vadim N Gladyshev

doi:10.1038/nature10533

Genome sequencing reveals insights into physiology and longevity of the naked mole rat

Eun Bae Kim, Xiaodong Fang, Alexey A Fushan, Zhiyong Huang, Alexei V Lobanov, Lijuan Han, Stefano M Marino, Xiaoqing Sun, Anton A Turanov, Pengcheng Yang, Sun Hee Yim, Xiang Zhao, Marina V Kasaikina, Nina Stoletzki, Chunfang Peng, Paz Polak, Zhiqiang Xiong, Adam Kiezun, Yabing Zhu, Yuanxin ChenGregory V Kryukov, Qiang Zhang, Leonid Peshkin, Lan Yang, Roderick T Bronson, Rochelle Buffenstein, Bo Wang, Changlei Han, Qiye Li, Li Chen, Wei Zhao, Shamil R Sunyaev, Thomas J Park, Guojie Zhang, Jun Wang, Vadim N Gladyshev

Ecology and Evolution

353 Citationer (Scopus)

Abstract

The naked mole rat (Heterocephalus glaber) is a strictly subterranean, extraordinarily long-lived eusocial mammal. Although it is the size of a mouse, its maximum lifespan exceeds 30 years, making this animal the longest-living rodent. Naked mole rats show negligible senescence, no age-related increase in mortality, and high fecundity until death. In addition to delayed ageing, they are resistant to both spontaneous cancer and experimentally induced tumorigenesis. Naked mole rats pose a challenge to the theories that link ageing, cancer and redox homeostasis. Although characterized by significant oxidative stress, the naked mole rat proteome does not show age-related susceptibility to oxidative damage or increased ubiquitination. Naked mole rats naturally reside in large colonies with a single breeding female, the 'queen', who suppresses the sexual maturity of her subordinates. They also live in full darkness, at low oxygen and high carbon dioxide concentrations, and are unable to sustain thermogenesis nor feel certain types of pain. Here we report the sequencing and analysis of the naked mole rat genome, which reveals unique genome features and molecular adaptations consistent with cancer resistance, poikilothermy, hairlessness and insensitivity to low oxygen, and altered visual function, circadian rythms and taste sensing. This information provides insights into the naked mole rat's exceptional longevity and ability to live in hostile conditions, in the dark and at low oxygen. The extreme traits of the naked mole rat, together with the reported genome and transcriptome information, offer opportunities for understanding ageing and advancing other areas of biological and biomedical research.

Originalsprog	Engelsk
Tidsskrift	Nature Photographer
Vol/bind	479
Udgave nummer	7372
Sider (fra-til)	223-7
Antal sider	5
ISSN	1049-6602
DOI	https://doi.org/10.1038/nature10533
Status	Udgivet - 10 nov. 2011

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Kim, E. B., Fang, X., Fushan, A. A., Huang, Z., Lobanov, A. V., Han, L., Marino, S. M., Sun, X., Turanov, A. A., Yang, P., Yim, S. H., Zhao, X., Kasaikina, M. V., Stoletzki, N., Peng, C., Polak, P., Xiong, Z., Kiezun, A., Zhu, Y., ... Gladyshev, V. N. (2011). Genome sequencing reveals insights into physiology and longevity of the naked mole rat. Nature Photographer, 479(7372), 223-7. https://doi.org/10.1038/nature10533

Kim, EB, Fang, X, Fushan, AA, Huang, Z, Lobanov, AV, Han, L, Marino, SM, Sun, X, Turanov, AA, Yang, P, Yim, SH, Zhao, X, Kasaikina, MV, Stoletzki, N, Peng, C, Polak, P, Xiong, Z, Kiezun, A, Zhu, Y, Chen, Y, Kryukov, GV, Zhang, Q, Peshkin, L, Yang, L, Bronson, RT, Buffenstein, R, Wang, B, Han, C, Li, Q, Chen, L, Zhao, W, Sunyaev, SR, Park, TJ, Zhang, G, Wang, J & Gladyshev, VN 2011, 'Genome sequencing reveals insights into physiology and longevity of the naked mole rat', Nature Photographer, bind 479, nr. 7372, s. 223-7. https://doi.org/10.1038/nature10533

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title = "Genome sequencing reveals insights into physiology and longevity of the naked mole rat",

abstract = "The naked mole rat (Heterocephalus glaber) is a strictly subterranean, extraordinarily long-lived eusocial mammal. Although it is the size of a mouse, its maximum lifespan exceeds 30 years, making this animal the longest-living rodent. Naked mole rats show negligible senescence, no age-related increase in mortality, and high fecundity until death. In addition to delayed ageing, they are resistant to both spontaneous cancer and experimentally induced tumorigenesis. Naked mole rats pose a challenge to the theories that link ageing, cancer and redox homeostasis. Although characterized by significant oxidative stress, the naked mole rat proteome does not show age-related susceptibility to oxidative damage or increased ubiquitination. Naked mole rats naturally reside in large colonies with a single breeding female, the 'queen', who suppresses the sexual maturity of her subordinates. They also live in full darkness, at low oxygen and high carbon dioxide concentrations, and are unable to sustain thermogenesis nor feel certain types of pain. Here we report the sequencing and analysis of the naked mole rat genome, which reveals unique genome features and molecular adaptations consistent with cancer resistance, poikilothermy, hairlessness and insensitivity to low oxygen, and altered visual function, circadian rythms and taste sensing. This information provides insights into the naked mole rat's exceptional longevity and ability to live in hostile conditions, in the dark and at low oxygen. The extreme traits of the naked mole rat, together with the reported genome and transcriptome information, offer opportunities for understanding ageing and advancing other areas of biological and biomedical research.",

keywords = "Adaptation, Physiological, Aging, Amino Acid Sequence, Animals, Body Temperature Regulation, Carbon Dioxide, Circadian Rhythm, Darkness, Genes, Genome, Genomic Instability, Genomics, Humans, Ion Channels, Longevity, Male, Mitochondrial Proteins, Mole Rats, Molecular Sequence Data, Mutagenesis, Oxygen, Taste, Transcriptome, Visual Perception",

author = "Kim, {Eun Bae} and Xiaodong Fang and Fushan, {Alexey A} and Zhiyong Huang and Lobanov, {Alexei V} and Lijuan Han and Marino, {Stefano M} and Xiaoqing Sun and Turanov, {Anton A} and Pengcheng Yang and Yim, {Sun Hee} and Xiang Zhao and Kasaikina, {Marina V} and Nina Stoletzki and Chunfang Peng and Paz Polak and Zhiqiang Xiong and Adam Kiezun and Yabing Zhu and Yuanxin Chen and Kryukov, {Gregory V} and Qiang Zhang and Leonid Peshkin and Lan Yang and Bronson, {Roderick T} and Rochelle Buffenstein and Bo Wang and Changlei Han and Qiye Li and Li Chen and Wei Zhao and Sunyaev, {Shamil R} and Park, {Thomas J} and Guojie Zhang and Jun Wang and Gladyshev, {Vadim N}",

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TY - JOUR

T1 - Genome sequencing reveals insights into physiology and longevity of the naked mole rat

AU - Kim, Eun Bae

AU - Fang, Xiaodong

AU - Fushan, Alexey A

AU - Huang, Zhiyong

AU - Lobanov, Alexei V

AU - Han, Lijuan

AU - Marino, Stefano M

AU - Sun, Xiaoqing

AU - Turanov, Anton A

AU - Yang, Pengcheng

AU - Yim, Sun Hee

AU - Zhao, Xiang

AU - Kasaikina, Marina V

AU - Stoletzki, Nina

AU - Peng, Chunfang

AU - Polak, Paz

AU - Xiong, Zhiqiang

AU - Kiezun, Adam

AU - Zhu, Yabing

AU - Chen, Yuanxin

AU - Kryukov, Gregory V

AU - Zhang, Qiang

AU - Peshkin, Leonid

AU - Yang, Lan

AU - Bronson, Roderick T

AU - Buffenstein, Rochelle

AU - Wang, Bo

AU - Han, Changlei

AU - Li, Qiye

AU - Chen, Li

AU - Zhao, Wei

AU - Sunyaev, Shamil R

AU - Park, Thomas J

AU - Zhang, Guojie

AU - Wang, Jun

AU - Gladyshev, Vadim N

PY - 2011/11/10

Y1 - 2011/11/10

N2 - The naked mole rat (Heterocephalus glaber) is a strictly subterranean, extraordinarily long-lived eusocial mammal. Although it is the size of a mouse, its maximum lifespan exceeds 30 years, making this animal the longest-living rodent. Naked mole rats show negligible senescence, no age-related increase in mortality, and high fecundity until death. In addition to delayed ageing, they are resistant to both spontaneous cancer and experimentally induced tumorigenesis. Naked mole rats pose a challenge to the theories that link ageing, cancer and redox homeostasis. Although characterized by significant oxidative stress, the naked mole rat proteome does not show age-related susceptibility to oxidative damage or increased ubiquitination. Naked mole rats naturally reside in large colonies with a single breeding female, the 'queen', who suppresses the sexual maturity of her subordinates. They also live in full darkness, at low oxygen and high carbon dioxide concentrations, and are unable to sustain thermogenesis nor feel certain types of pain. Here we report the sequencing and analysis of the naked mole rat genome, which reveals unique genome features and molecular adaptations consistent with cancer resistance, poikilothermy, hairlessness and insensitivity to low oxygen, and altered visual function, circadian rythms and taste sensing. This information provides insights into the naked mole rat's exceptional longevity and ability to live in hostile conditions, in the dark and at low oxygen. The extreme traits of the naked mole rat, together with the reported genome and transcriptome information, offer opportunities for understanding ageing and advancing other areas of biological and biomedical research.

AB - The naked mole rat (Heterocephalus glaber) is a strictly subterranean, extraordinarily long-lived eusocial mammal. Although it is the size of a mouse, its maximum lifespan exceeds 30 years, making this animal the longest-living rodent. Naked mole rats show negligible senescence, no age-related increase in mortality, and high fecundity until death. In addition to delayed ageing, they are resistant to both spontaneous cancer and experimentally induced tumorigenesis. Naked mole rats pose a challenge to the theories that link ageing, cancer and redox homeostasis. Although characterized by significant oxidative stress, the naked mole rat proteome does not show age-related susceptibility to oxidative damage or increased ubiquitination. Naked mole rats naturally reside in large colonies with a single breeding female, the 'queen', who suppresses the sexual maturity of her subordinates. They also live in full darkness, at low oxygen and high carbon dioxide concentrations, and are unable to sustain thermogenesis nor feel certain types of pain. Here we report the sequencing and analysis of the naked mole rat genome, which reveals unique genome features and molecular adaptations consistent with cancer resistance, poikilothermy, hairlessness and insensitivity to low oxygen, and altered visual function, circadian rythms and taste sensing. This information provides insights into the naked mole rat's exceptional longevity and ability to live in hostile conditions, in the dark and at low oxygen. The extreme traits of the naked mole rat, together with the reported genome and transcriptome information, offer opportunities for understanding ageing and advancing other areas of biological and biomedical research.

KW - Adaptation, Physiological

KW - Aging

KW - Amino Acid Sequence

KW - Animals

KW - Body Temperature Regulation

KW - Carbon Dioxide

KW - Circadian Rhythm

KW - Darkness

KW - Genes

KW - Genome

KW - Genomic Instability

KW - Genomics

KW - Humans

KW - Ion Channels

KW - Longevity

KW - Male

KW - Mitochondrial Proteins

KW - Mole Rats

KW - Molecular Sequence Data

KW - Mutagenesis

KW - Oxygen

KW - Taste

KW - Transcriptome

KW - Visual Perception

U2 - 10.1038/nature10533

DO - 10.1038/nature10533

M3 - Journal article

C2 - 21993625

SN - 1049-6602

VL - 479

SP - 223

EP - 227

JO - Nature Photographer

JF - Nature Photographer

IS - 7372

ER -

Genome sequencing reveals insights into physiology and longevity of the naked mole rat

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