Genetic risk scores for major psychiatric disorders and the risk of postpartum psychiatric disorders

Anna E Bauer; Xiaoqin Liu; Enda M Byrne; Patrick F Sullivan; Naomi R Wray; Esben Agerbo; Mette Nyegaard; Jakob Grove; Katherine L Musliner; Katja G Ingstrup; Benedicte M W Johannsen; Merete L Mægbæk; Yunpeng Wang; Merete Nordentoft; Ole Mors; Anders D Børglum; Thomas Werge; David M Hougaard; Preben Bo Mortensen; Trine Munk-Olsen; Samantha Meltzer-Brody

doi:10.1038/s41398-019-0629-9

Genetic risk scores for major psychiatric disorders and the risk of postpartum psychiatric disorders

Anna E Bauer, Xiaoqin Liu, Enda M Byrne, Patrick F Sullivan, Naomi R Wray, Esben Agerbo, Mette Nyegaard, Jakob Grove, Katherine L Musliner, Katja G Ingstrup, Benedicte M W Johannsen, Merete L Mægbæk, Yunpeng Wang, Merete Nordentoft, Ole Mors, Anders D Børglum, Thomas Werge, David M Hougaard, Preben Bo Mortensen, Trine Munk-OlsenSamantha Meltzer-Brody

Department of Clinical Medicine

7 Citations (Scopus)

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Abstract

Postpartum psychiatric disorders are heritable, but how genetic liability varies by other significant risk factors is unknown. We aimed to (1) estimate associations of genetic risk scores (GRS) for major depression (MD), bipolar disorder (BD), and schizophrenia (SCZ) with postpartum psychiatric disorders, (2) examine differences by prior psychiatric history, and (3) compare genetic and familial risk of postpartum psychiatric disorders. We conducted a nested case-control study based on Danish population-based registers of all women in the iPSYCH2012 cohort who had given birth before December 31, 2015 (n = 8850). Cases were women with a diagnosed psychiatric disorder or a filled psychotropic prescription within one year after delivery (n = 5829 cases, 3021 controls). Association analyses were conducted between GRS calculated from Psychiatric Genomics Consortium discovery meta-analyses for MD, BD, and SCZ and case-control status of a postpartum psychiatric disorder. Parental psychiatric history was associated with postpartum psychiatric disorders among women with previous psychiatric history (OR, 1.14; 95% CI 1.02-1.28) but not without psychiatric history (OR, 1.08; 95% CI: 0.81-1.43). GRS for MD was associated with an increased risk of postpartum psychiatric disorders in both women with (OR, 1.44; 95% CI: 1.19-1.74) and without (OR, 1.88; 95% CI: 1.26-2.81) personal psychiatric history. SCZ GRS was only minimally associated with postpartum disorders and BD GRS was not. Results suggest GRS of lifetime psychiatric illness can be applied to the postpartum period, which may provide clues about distinct environmental or genetic elements of postpartum psychiatric disorders and ultimately help identify vulnerable groups.

Original language	English
Article number	288
Journal	Translational Psychiatry
Volume	9
Issue number	1
Number of pages	13
ISSN	2158-3188
DOIs	https://doi.org/10.1038/s41398-019-0629-9
Publication status	Published - 1 Dec 2019

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Genetic risk scores for major psychiatric disorders and the risk of postpartum psychiatric disordersFinal published version, 1.21 MBLicence: CC BY

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Bauer, A. E., Liu, X., Byrne, E. M., Sullivan, P. F., Wray, N. R., Agerbo, E., Nyegaard, M., Grove, J., Musliner, K. L., Ingstrup, K. G., Johannsen, B. M. W., Mægbæk, M. L., Wang, Y., Nordentoft, M., Mors, O., Børglum, A. D., Werge, T., Hougaard, D. M., Mortensen, P. B., ... Meltzer-Brody, S. (2019). Genetic risk scores for major psychiatric disorders and the risk of postpartum psychiatric disorders. Translational Psychiatry, 9(1), [288]. https://doi.org/10.1038/s41398-019-0629-9

Bauer, AE, Liu, X, Byrne, EM, Sullivan, PF, Wray, NR, Agerbo, E, Nyegaard, M, Grove, J, Musliner, KL, Ingstrup, KG, Johannsen, BMW, Mægbæk, ML, Wang, Y, Nordentoft, M, Mors, O, Børglum, AD, Werge, T, Hougaard, DM, Mortensen, PB, Munk-Olsen, T & Meltzer-Brody, S 2019, 'Genetic risk scores for major psychiatric disorders and the risk of postpartum psychiatric disorders', Translational Psychiatry, vol. 9, no. 1, 288. https://doi.org/10.1038/s41398-019-0629-9

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abstract = "Postpartum psychiatric disorders are heritable, but how genetic liability varies by other significant risk factors is unknown. We aimed to (1) estimate associations of genetic risk scores (GRS) for major depression (MD), bipolar disorder (BD), and schizophrenia (SCZ) with postpartum psychiatric disorders, (2) examine differences by prior psychiatric history, and (3) compare genetic and familial risk of postpartum psychiatric disorders. We conducted a nested case-control study based on Danish population-based registers of all women in the iPSYCH2012 cohort who had given birth before December 31, 2015 (n = 8850). Cases were women with a diagnosed psychiatric disorder or a filled psychotropic prescription within one year after delivery (n = 5829 cases, 3021 controls). Association analyses were conducted between GRS calculated from Psychiatric Genomics Consortium discovery meta-analyses for MD, BD, and SCZ and case-control status of a postpartum psychiatric disorder. Parental psychiatric history was associated with postpartum psychiatric disorders among women with previous psychiatric history (OR, 1.14; 95% CI 1.02-1.28) but not without psychiatric history (OR, 1.08; 95% CI: 0.81-1.43). GRS for MD was associated with an increased risk of postpartum psychiatric disorders in both women with (OR, 1.44; 95% CI: 1.19-1.74) and without (OR, 1.88; 95% CI: 1.26-2.81) personal psychiatric history. SCZ GRS was only minimally associated with postpartum disorders and BD GRS was not. Results suggest GRS of lifetime psychiatric illness can be applied to the postpartum period, which may provide clues about distinct environmental or genetic elements of postpartum psychiatric disorders and ultimately help identify vulnerable groups.",

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AU - Bauer, Anna E

AU - Liu, Xiaoqin

AU - Byrne, Enda M

AU - Sullivan, Patrick F

AU - Wray, Naomi R

AU - Agerbo, Esben

AU - Nyegaard, Mette

AU - Grove, Jakob

AU - Musliner, Katherine L

AU - Ingstrup, Katja G

AU - Johannsen, Benedicte M W

AU - Mægbæk, Merete L

AU - Wang, Yunpeng

AU - Nordentoft, Merete

AU - Mors, Ole

AU - Børglum, Anders D

AU - Werge, Thomas

AU - Hougaard, David M

AU - Mortensen, Preben Bo

AU - Munk-Olsen, Trine

AU - Meltzer-Brody, Samantha

PY - 2019/12/1

Y1 - 2019/12/1

N2 - Postpartum psychiatric disorders are heritable, but how genetic liability varies by other significant risk factors is unknown. We aimed to (1) estimate associations of genetic risk scores (GRS) for major depression (MD), bipolar disorder (BD), and schizophrenia (SCZ) with postpartum psychiatric disorders, (2) examine differences by prior psychiatric history, and (3) compare genetic and familial risk of postpartum psychiatric disorders. We conducted a nested case-control study based on Danish population-based registers of all women in the iPSYCH2012 cohort who had given birth before December 31, 2015 (n = 8850). Cases were women with a diagnosed psychiatric disorder or a filled psychotropic prescription within one year after delivery (n = 5829 cases, 3021 controls). Association analyses were conducted between GRS calculated from Psychiatric Genomics Consortium discovery meta-analyses for MD, BD, and SCZ and case-control status of a postpartum psychiatric disorder. Parental psychiatric history was associated with postpartum psychiatric disorders among women with previous psychiatric history (OR, 1.14; 95% CI 1.02-1.28) but not without psychiatric history (OR, 1.08; 95% CI: 0.81-1.43). GRS for MD was associated with an increased risk of postpartum psychiatric disorders in both women with (OR, 1.44; 95% CI: 1.19-1.74) and without (OR, 1.88; 95% CI: 1.26-2.81) personal psychiatric history. SCZ GRS was only minimally associated with postpartum disorders and BD GRS was not. Results suggest GRS of lifetime psychiatric illness can be applied to the postpartum period, which may provide clues about distinct environmental or genetic elements of postpartum psychiatric disorders and ultimately help identify vulnerable groups.

AB - Postpartum psychiatric disorders are heritable, but how genetic liability varies by other significant risk factors is unknown. We aimed to (1) estimate associations of genetic risk scores (GRS) for major depression (MD), bipolar disorder (BD), and schizophrenia (SCZ) with postpartum psychiatric disorders, (2) examine differences by prior psychiatric history, and (3) compare genetic and familial risk of postpartum psychiatric disorders. We conducted a nested case-control study based on Danish population-based registers of all women in the iPSYCH2012 cohort who had given birth before December 31, 2015 (n = 8850). Cases were women with a diagnosed psychiatric disorder or a filled psychotropic prescription within one year after delivery (n = 5829 cases, 3021 controls). Association analyses were conducted between GRS calculated from Psychiatric Genomics Consortium discovery meta-analyses for MD, BD, and SCZ and case-control status of a postpartum psychiatric disorder. Parental psychiatric history was associated with postpartum psychiatric disorders among women with previous psychiatric history (OR, 1.14; 95% CI 1.02-1.28) but not without psychiatric history (OR, 1.08; 95% CI: 0.81-1.43). GRS for MD was associated with an increased risk of postpartum psychiatric disorders in both women with (OR, 1.44; 95% CI: 1.19-1.74) and without (OR, 1.88; 95% CI: 1.26-2.81) personal psychiatric history. SCZ GRS was only minimally associated with postpartum disorders and BD GRS was not. Results suggest GRS of lifetime psychiatric illness can be applied to the postpartum period, which may provide clues about distinct environmental or genetic elements of postpartum psychiatric disorders and ultimately help identify vulnerable groups.

U2 - 10.1038/s41398-019-0629-9

DO - 10.1038/s41398-019-0629-9

M3 - Journal article

C2 - 31712652

SN - 2158-3188

VL - 9

JO - Translational Psychiatry

JF - Translational Psychiatry

IS - 1

M1 - 288

ER -

Genetic risk scores for major psychiatric disorders and the risk of postpartum psychiatric disorders

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