Genetic predisposition to adiposity is associated with increased objectively assessed sedentary time in young children

Theresia Maria Schnurr; A Viitasalo; A-M Eloranta; Camilla Trab Damsgaard; Yuvaraj Mahendran; Christian Theil Have; J Väistö; Mads Fiil Hjorth; Line Brinch Christensen; S Brage; M Atalay; L-P Lyytikäinen; V Lindi; T Lakka; Kim F. Michaelsen; Tuomas Oskari Kilpeläinen; Torben Hansen

doi:10.1038/ijo.2017.235

Genetic predisposition to adiposity is associated with increased objectively assessed sedentary time in young children

Theresia Maria Schnurr, A Viitasalo, A-M Eloranta, Camilla Trab Damsgaard, Yuvaraj Mahendran, Christian Theil Have, J Väistö, Mads Fiil Hjorth, Line Brinch Christensen, S Brage, M Atalay, L-P Lyytikäinen, V Lindi, T Lakka, Kim F. Michaelsen, Tuomas Oskari Kilpeläinen, Torben Hansen

5 Citations (Scopus)

Abstract

Increased sedentariness has been linked to the growing prevalence of obesity in children, but some longitudinal studies suggest that sedentariness may be a consequence rather than a cause of increased adiposity. We used Mendelian randomization to examine the causal relations between body mass index (BMI) and objectively assessed sedentary time and physical activity in 3-8 year-old children from one Finnish and two Danish cohorts [N TOTAL =679]. A genetic risk score (GRS) comprised of 15 independent genetic variants associated with childhood BMI was used as the instrumental variable to test causal effects of BMI on sedentary time, total physical activity, and moderate-to-vigorous physical activity (MVPA). In fixed effects meta-analyses, the GRS was associated with 0.05 SD/allele increase in sedentary time (P=0.019), but there was no significant association with total physical activity (beta=0.011 SD/allele, P=0.58) or MVPA (beta=0.001 SD/allele, P=0.96), adjusting for age, sex, monitor wear-time and first three genome-wide principal components. In two-stage least squares regression analyses, each genetically instrumented one unit increase in BMI z-score increased sedentary time by 0.47 SD (P=0.072). Childhood BMI may have a causal influence on sedentary time but not on total physical activity or MVPA in young children. Our results provide important insights into the regulation of movement behaviour in childhood.

Original language	English
Journal	International Journal of Obesity
Volume	42
Issue number	1
Pages (from-to)	111-114
Number of pages	4
ISSN	0307-0565
DOIs	https://doi.org/10.1038/ijo.2017.235
Publication status	Published - 1 Jan 2018

Keywords

Genetic risk score
Childhood BMI
Adiposity
Sedentary time
Mendelian randomization

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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Schnurr, T. M., Viitasalo, A., Eloranta, A-M., Damsgaard, C. T., Mahendran, Y., Have, C. T., Väistö, J., Hjorth, M. F., Christensen, L. B., Brage, S., Atalay, M., Lyytikäinen, L-P., Lindi, V., Lakka, T., Michaelsen, K. F., Kilpeläinen, T. O., & Hansen, T. (2018). Genetic predisposition to adiposity is associated with increased objectively assessed sedentary time in young children. International Journal of Obesity, 42(1), 111-114. https://doi.org/10.1038/ijo.2017.235

Schnurr, TM, Viitasalo, A, Eloranta, A-M, Damsgaard, CT, Mahendran, Y, Have, CT, Väistö, J, Hjorth, MF, Christensen, LB, Brage, S, Atalay, M, Lyytikäinen, L-P, Lindi, V, Lakka, T, Michaelsen, KF , Kilpeläinen, TO & Hansen, T 2018, 'Genetic predisposition to adiposity is associated with increased objectively assessed sedentary time in young children', International Journal of Obesity, vol. 42, no. 1, pp. 111-114. https://doi.org/10.1038/ijo.2017.235

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abstract = "Increased sedentariness has been linked to the growing prevalence of obesity in children, but some longitudinal studies suggest that sedentariness may be a consequence rather than a cause of increased adiposity. We used Mendelian randomization to examine the causal relations between body mass index (BMI) and objectively assessed sedentary time and physical activity in 3-8 year-old children from one Finnish and two Danish cohorts [N TOTAL =679]. A genetic risk score (GRS) comprised of 15 independent genetic variants associated with childhood BMI was used as the instrumental variable to test causal effects of BMI on sedentary time, total physical activity, and moderate-to-vigorous physical activity (MVPA). In fixed effects meta-analyses, the GRS was associated with 0.05 SD/allele increase in sedentary time (P=0.019), but there was no significant association with total physical activity (beta=0.011 SD/allele, P=0.58) or MVPA (beta=0.001 SD/allele, P=0.96), adjusting for age, sex, monitor wear-time and first three genome-wide principal components. In two-stage least squares regression analyses, each genetically instrumented one unit increase in BMI z-score increased sedentary time by 0.47 SD (P=0.072). Childhood BMI may have a causal influence on sedentary time but not on total physical activity or MVPA in young children. Our results provide important insights into the regulation of movement behaviour in childhood.",

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AU - Schnurr, Theresia Maria

AU - Viitasalo, A

AU - Eloranta, A-M

AU - Damsgaard, Camilla Trab

AU - Mahendran, Yuvaraj

AU - Have, Christian Theil

AU - Väistö, J

AU - Hjorth, Mads Fiil

AU - Christensen, Line Brinch

AU - Brage, S

AU - Atalay, M

AU - Lyytikäinen, L-P

AU - Lindi, V

AU - Lakka, T

AU - Michaelsen, Kim F.

AU - Kilpeläinen, Tuomas Oskari

AU - Hansen, Torben

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N2 - Increased sedentariness has been linked to the growing prevalence of obesity in children, but some longitudinal studies suggest that sedentariness may be a consequence rather than a cause of increased adiposity. We used Mendelian randomization to examine the causal relations between body mass index (BMI) and objectively assessed sedentary time and physical activity in 3-8 year-old children from one Finnish and two Danish cohorts [N TOTAL =679]. A genetic risk score (GRS) comprised of 15 independent genetic variants associated with childhood BMI was used as the instrumental variable to test causal effects of BMI on sedentary time, total physical activity, and moderate-to-vigorous physical activity (MVPA). In fixed effects meta-analyses, the GRS was associated with 0.05 SD/allele increase in sedentary time (P=0.019), but there was no significant association with total physical activity (beta=0.011 SD/allele, P=0.58) or MVPA (beta=0.001 SD/allele, P=0.96), adjusting for age, sex, monitor wear-time and first three genome-wide principal components. In two-stage least squares regression analyses, each genetically instrumented one unit increase in BMI z-score increased sedentary time by 0.47 SD (P=0.072). Childhood BMI may have a causal influence on sedentary time but not on total physical activity or MVPA in young children. Our results provide important insights into the regulation of movement behaviour in childhood.

AB - Increased sedentariness has been linked to the growing prevalence of obesity in children, but some longitudinal studies suggest that sedentariness may be a consequence rather than a cause of increased adiposity. We used Mendelian randomization to examine the causal relations between body mass index (BMI) and objectively assessed sedentary time and physical activity in 3-8 year-old children from one Finnish and two Danish cohorts [N TOTAL =679]. A genetic risk score (GRS) comprised of 15 independent genetic variants associated with childhood BMI was used as the instrumental variable to test causal effects of BMI on sedentary time, total physical activity, and moderate-to-vigorous physical activity (MVPA). In fixed effects meta-analyses, the GRS was associated with 0.05 SD/allele increase in sedentary time (P=0.019), but there was no significant association with total physical activity (beta=0.011 SD/allele, P=0.58) or MVPA (beta=0.001 SD/allele, P=0.96), adjusting for age, sex, monitor wear-time and first three genome-wide principal components. In two-stage least squares regression analyses, each genetically instrumented one unit increase in BMI z-score increased sedentary time by 0.47 SD (P=0.072). Childhood BMI may have a causal influence on sedentary time but not on total physical activity or MVPA in young children. Our results provide important insights into the regulation of movement behaviour in childhood.

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KW - Childhood BMI

KW - Adiposity

KW - Sedentary time

KW - Mendelian randomization

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DO - 10.1038/ijo.2017.235

M3 - Journal article

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VL - 42

SP - 111

EP - 114

JO - International Journal of Obesity

JF - International Journal of Obesity

IS - 1

ER -

Genetic predisposition to adiposity is associated with increased objectively assessed sedentary time in young children

Abstract

Keywords

UN SDGs

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