Genetic predisposition to adiposity is associated with increased objectively assessed sedentary time in young children

Theresia Maria Schnurr; A Viitasalo; A-M Eloranta; Camilla Trab Damsgaard; Yuvaraj Mahendran; Christian Theil Have; J Väistö; Mads Fiil Hjorth; Line Brinch Christensen; S Brage; M Atalay; L-P Lyytikäinen; V Lindi; T Lakka; Kim F. Michaelsen; Tuomas Oskari Kilpeläinen; Torben Hansen

doi:10.1038/ijo.2017.235

Genetic predisposition to adiposity is associated with increased objectively assessed sedentary time in young children

Theresia Maria Schnurr, A Viitasalo, A-M Eloranta, Camilla Trab Damsgaard, Yuvaraj Mahendran, Christian Theil Have, J Väistö, Mads Fiil Hjorth, Line Brinch Christensen, S Brage, M Atalay, L-P Lyytikäinen, V Lindi, T Lakka, Kim F. Michaelsen, Tuomas Oskari Kilpeläinen, Torben Hansen

5 Citationer (Scopus)

Abstract

Increased sedentariness has been linked to the growing prevalence of obesity in children, but some longitudinal studies suggest that sedentariness may be a consequence rather than a cause of increased adiposity. We used Mendelian randomization to examine the causal relations between body mass index (BMI) and objectively assessed sedentary time and physical activity in 3-8 year-old children from one Finnish and two Danish cohorts [N TOTAL =679]. A genetic risk score (GRS) comprised of 15 independent genetic variants associated with childhood BMI was used as the instrumental variable to test causal effects of BMI on sedentary time, total physical activity, and moderate-to-vigorous physical activity (MVPA). In fixed effects meta-analyses, the GRS was associated with 0.05 SD/allele increase in sedentary time (P=0.019), but there was no significant association with total physical activity (beta=0.011 SD/allele, P=0.58) or MVPA (beta=0.001 SD/allele, P=0.96), adjusting for age, sex, monitor wear-time and first three genome-wide principal components. In two-stage least squares regression analyses, each genetically instrumented one unit increase in BMI z-score increased sedentary time by 0.47 SD (P=0.072). Childhood BMI may have a causal influence on sedentary time but not on total physical activity or MVPA in young children. Our results provide important insights into the regulation of movement behaviour in childhood.

Originalsprog	Engelsk
Tidsskrift	International Journal of Obesity
Vol/bind	42
Udgave nummer	1
Sider (fra-til)	111-114
Antal sider	4
ISSN	0307-0565
DOI	https://doi.org/10.1038/ijo.2017.235
Status	Udgivet - 1 jan. 2018

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10.1038/ijo.2017.235

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Schnurr, T. M., Viitasalo, A., Eloranta, A.-M., Damsgaard, C. T., Mahendran, Y., Have, C. T., Väistö, J., Hjorth, M. F., Christensen, L. B., Brage, S., Atalay, M., Lyytikäinen, L.-P., Lindi, V., Lakka, T., Michaelsen, K. F., Kilpeläinen, T. O., & Hansen, T. (2018). Genetic predisposition to adiposity is associated with increased objectively assessed sedentary time in young children. International Journal of Obesity, 42(1), 111-114. https://doi.org/10.1038/ijo.2017.235

Schnurr, TM, Viitasalo, A, Eloranta, A-M, Damsgaard, CT, Mahendran, Y, Have, CT, Väistö, J, Hjorth, MF, Christensen, LB, Brage, S, Atalay, M, Lyytikäinen, L-P, Lindi, V, Lakka, T, Michaelsen, KF , Kilpeläinen, TO & Hansen, T 2018, 'Genetic predisposition to adiposity is associated with increased objectively assessed sedentary time in young children', International Journal of Obesity, bind 42, nr. 1, s. 111-114. https://doi.org/10.1038/ijo.2017.235

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title = "Genetic predisposition to adiposity is associated with increased objectively assessed sedentary time in young children",

abstract = "Increased sedentariness has been linked to the growing prevalence of obesity in children, but some longitudinal studies suggest that sedentariness may be a consequence rather than a cause of increased adiposity. We used Mendelian randomization to examine the causal relations between body mass index (BMI) and objectively assessed sedentary time and physical activity in 3-8 year-old children from one Finnish and two Danish cohorts [N TOTAL =679]. A genetic risk score (GRS) comprised of 15 independent genetic variants associated with childhood BMI was used as the instrumental variable to test causal effects of BMI on sedentary time, total physical activity, and moderate-to-vigorous physical activity (MVPA). In fixed effects meta-analyses, the GRS was associated with 0.05 SD/allele increase in sedentary time (P=0.019), but there was no significant association with total physical activity (beta=0.011 SD/allele, P=0.58) or MVPA (beta=0.001 SD/allele, P=0.96), adjusting for age, sex, monitor wear-time and first three genome-wide principal components. In two-stage least squares regression analyses, each genetically instrumented one unit increase in BMI z-score increased sedentary time by 0.47 SD (P=0.072). Childhood BMI may have a causal influence on sedentary time but not on total physical activity or MVPA in young children. Our results provide important insights into the regulation of movement behaviour in childhood.",

keywords = "Genetic risk score, Childhood BMI, Adiposity, Sedentary time, Mendelian randomization",

author = "Schnurr, {Theresia Maria} and A Viitasalo and A-M Eloranta and Damsgaard, {Camilla Trab} and Yuvaraj Mahendran and Have, {Christian Theil} and J V{\"a}ist{\"o} and Hjorth, {Mads Fiil} and Christensen, {Line Brinch} and S Brage and M Atalay and L-P Lyytik{\"a}inen and V Lindi and T Lakka and Michaelsen, {Kim F.} and Kilpel{\"a}inen, {Tuomas Oskari} and Torben Hansen",

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doi = "10.1038/ijo.2017.235",

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T1 - Genetic predisposition to adiposity is associated with increased objectively assessed sedentary time in young children

AU - Schnurr, Theresia Maria

AU - Viitasalo, A

AU - Eloranta, A-M

AU - Damsgaard, Camilla Trab

AU - Mahendran, Yuvaraj

AU - Have, Christian Theil

AU - Väistö, J

AU - Hjorth, Mads Fiil

AU - Christensen, Line Brinch

AU - Brage, S

AU - Atalay, M

AU - Lyytikäinen, L-P

AU - Lindi, V

AU - Lakka, T

AU - Michaelsen, Kim F.

AU - Kilpeläinen, Tuomas Oskari

AU - Hansen, Torben

N1 - CURIS 2018 NEXS 035

PY - 2018/1/1

Y1 - 2018/1/1

N2 - Increased sedentariness has been linked to the growing prevalence of obesity in children, but some longitudinal studies suggest that sedentariness may be a consequence rather than a cause of increased adiposity. We used Mendelian randomization to examine the causal relations between body mass index (BMI) and objectively assessed sedentary time and physical activity in 3-8 year-old children from one Finnish and two Danish cohorts [N TOTAL =679]. A genetic risk score (GRS) comprised of 15 independent genetic variants associated with childhood BMI was used as the instrumental variable to test causal effects of BMI on sedentary time, total physical activity, and moderate-to-vigorous physical activity (MVPA). In fixed effects meta-analyses, the GRS was associated with 0.05 SD/allele increase in sedentary time (P=0.019), but there was no significant association with total physical activity (beta=0.011 SD/allele, P=0.58) or MVPA (beta=0.001 SD/allele, P=0.96), adjusting for age, sex, monitor wear-time and first three genome-wide principal components. In two-stage least squares regression analyses, each genetically instrumented one unit increase in BMI z-score increased sedentary time by 0.47 SD (P=0.072). Childhood BMI may have a causal influence on sedentary time but not on total physical activity or MVPA in young children. Our results provide important insights into the regulation of movement behaviour in childhood.

AB - Increased sedentariness has been linked to the growing prevalence of obesity in children, but some longitudinal studies suggest that sedentariness may be a consequence rather than a cause of increased adiposity. We used Mendelian randomization to examine the causal relations between body mass index (BMI) and objectively assessed sedentary time and physical activity in 3-8 year-old children from one Finnish and two Danish cohorts [N TOTAL =679]. A genetic risk score (GRS) comprised of 15 independent genetic variants associated with childhood BMI was used as the instrumental variable to test causal effects of BMI on sedentary time, total physical activity, and moderate-to-vigorous physical activity (MVPA). In fixed effects meta-analyses, the GRS was associated with 0.05 SD/allele increase in sedentary time (P=0.019), but there was no significant association with total physical activity (beta=0.011 SD/allele, P=0.58) or MVPA (beta=0.001 SD/allele, P=0.96), adjusting for age, sex, monitor wear-time and first three genome-wide principal components. In two-stage least squares regression analyses, each genetically instrumented one unit increase in BMI z-score increased sedentary time by 0.47 SD (P=0.072). Childhood BMI may have a causal influence on sedentary time but not on total physical activity or MVPA in young children. Our results provide important insights into the regulation of movement behaviour in childhood.

KW - Genetic risk score

KW - Childhood BMI

KW - Adiposity

KW - Sedentary time

KW - Mendelian randomization

U2 - 10.1038/ijo.2017.235

DO - 10.1038/ijo.2017.235

M3 - Journal article

C2 - 28947836

SN - 0307-0565

VL - 42

SP - 111

EP - 114

JO - International Journal of Obesity

JF - International Journal of Obesity

IS - 1

ER -

Genetic predisposition to adiposity is associated with increased objectively assessed sedentary time in young children

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