Gender and the use of hormonal contraception in women are not associated with cerebral cortical 5-HT 2A receptor binding

TY - JOUR

T1 - Gender and the use of hormonal contraception in women are not associated with cerebral cortical 5-HT 2A receptor binding

AU - Frokjaer, V G

AU - Erritzoe, D

AU - Madsen, J

AU - Paulson, O B

AU - Knudsen, G M

N1 - Keywords: Adolescent; Adult; Aged; Cerebral Cortex; Contraceptives, Oral, Hormonal; Female; Humans; Ketanserin; Linear Models; Magnetic Resonance Imaging; Male; Middle Aged; Personality; Personality Assessment; Positron-Emission Tomography; Protein Binding; Receptor, Serotonin, 5-HT2A; Sex Characteristics; Young Adult

PY - 2009

Y1 - 2009

N2 - Gender influences brain function including serotonergic neurotransmission, which may play a role in the well-known gender variations in vulnerability to mood and anxiety disorders. Even though hormonal replacement therapy in menopause is associated with globally increased cerebral 5-HT(2A) receptor binding it is not clear if gender or use of hormonal contraception exhibits associations with 5-HT(2A) receptor binding. We found no significant effect of gender on cortical 5-HT(2A) receptor binding (P=0.15, n=132). When adjusting for the personality trait neuroticism, known to be positively correlated to frontolimbic 5-HT(2A) receptor binding and to be more pronounced in women, again, the effect of gender was not significant (P=0.42, n=127). Also, the use of hormonal contraception (n=14) within the group of pre-menopausal women (total n=29) was not associated with cortical 5-HT(2A) receptor binding (P=0.31). In conclusion, neither gender, nor the use of hormonal contraception in premenopausal women was associated with cortical 5-HT(2A) receptor binding.

AB - Gender influences brain function including serotonergic neurotransmission, which may play a role in the well-known gender variations in vulnerability to mood and anxiety disorders. Even though hormonal replacement therapy in menopause is associated with globally increased cerebral 5-HT(2A) receptor binding it is not clear if gender or use of hormonal contraception exhibits associations with 5-HT(2A) receptor binding. We found no significant effect of gender on cortical 5-HT(2A) receptor binding (P=0.15, n=132). When adjusting for the personality trait neuroticism, known to be positively correlated to frontolimbic 5-HT(2A) receptor binding and to be more pronounced in women, again, the effect of gender was not significant (P=0.42, n=127). Also, the use of hormonal contraception (n=14) within the group of pre-menopausal women (total n=29) was not associated with cortical 5-HT(2A) receptor binding (P=0.31). In conclusion, neither gender, nor the use of hormonal contraception in premenopausal women was associated with cortical 5-HT(2A) receptor binding.

U2 - 10.1016/j.neuroscience.2009.06.052

DO - 10.1016/j.neuroscience.2009.06.052

M3 - Journal article

C2 - 19559762

SN - 0306-4522

VL - 163

SP - 640

EP - 645

JO - Neuroscience

JF - Neuroscience

IS - 2

ER -