@article{a860eca06a4b11df928f000ea68e967b,
title = "Gender and the use of hormonal contraception in women are not associated with cerebral cortical 5-HT 2A receptor binding",
abstract = "Gender influences brain function including serotonergic neurotransmission, which may play a role in the well-known gender variations in vulnerability to mood and anxiety disorders. Even though hormonal replacement therapy in menopause is associated with globally increased cerebral 5-HT(2A) receptor binding it is not clear if gender or use of hormonal contraception exhibits associations with 5-HT(2A) receptor binding. We found no significant effect of gender on cortical 5-HT(2A) receptor binding (P=0.15, n=132). When adjusting for the personality trait neuroticism, known to be positively correlated to frontolimbic 5-HT(2A) receptor binding and to be more pronounced in women, again, the effect of gender was not significant (P=0.42, n=127). Also, the use of hormonal contraception (n=14) within the group of pre-menopausal women (total n=29) was not associated with cortical 5-HT(2A) receptor binding (P=0.31). In conclusion, neither gender, nor the use of hormonal contraception in premenopausal women was associated with cortical 5-HT(2A) receptor binding.",
author = "Frokjaer, {V G} and D Erritzoe and J Madsen and Paulson, {O B} and Knudsen, {G M}",
note = "Keywords: Adolescent; Adult; Aged; Cerebral Cortex; Contraceptives, Oral, Hormonal; Female; Humans; Ketanserin; Linear Models; Magnetic Resonance Imaging; Male; Middle Aged; Personality; Personality Assessment; Positron-Emission Tomography; Protein Binding; Receptor, Serotonin, 5-HT2A; Sex Characteristics; Young Adult",
year = "2009",
doi = "10.1016/j.neuroscience.2009.06.052",
language = "English",
volume = "163",
pages = "640--5",
journal = "Neuroscience",
issn = "0306-4522",
publisher = "Pergamon Press",
number = "2",
}