Gastrointestinal regulatory peptides in familial adenomatous polyposis

Peter Skov Olsen; Steffen Bülow; Per N. Jørgensen; Steen Seier Poulsen; Ebba Nexø

doi:10.1159/000200350

Gastrointestinal regulatory peptides in familial adenomatous polyposis

Peter Skov Olsen^*, Steffen Bülow, Per N. Jørgensen, Steen Seier Poulsen, Ebba Nexø

^*Corresponding author for this work

1 Citation (Scopus)

Abstract

The etiology of adenomas in the stomach and duodenum in patients with familial adenomatous polyposis (FAP) is unknown. In this study the plasma concentration of epidermal growth factor (EGF), and other gastrointestinal polypeptides with a possible trophic effect on the gastrointestinal mucosa, was unchanged before and after meal stimulation. In 3 of 7 patients an increased EGF immunoreactivity was found in duodenal adenomas. This study has not indicated that regulatory peptides are involved in development of duodenal polyps in FAP. but suggests further studies to determine the role of EGF in FAP.

Original language	English
Journal	Digestion
Volume	46
Issue number	4
Pages (from-to)	228-232
Number of pages	5
ISSN	0012-2823
DOIs	https://doi.org/10.1159/000200350
Publication status	Published - 1 Jan 1990

Keywords

Duodenal polyps
Familial adenomatous polyposis
Regulatory peptides

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10.1159/000200350

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title = "Gastrointestinal regulatory peptides in familial adenomatous polyposis",

abstract = "The etiology of adenomas in the stomach and duodenum in patients with familial adenomatous polyposis (FAP) is unknown. In this study the plasma concentration of epidermal growth factor (EGF), and other gastrointestinal polypeptides with a possible trophic effect on the gastrointestinal mucosa, was unchanged before and after meal stimulation. In 3 of 7 patients an increased EGF immunoreactivity was found in duodenal adenomas. This study has not indicated that regulatory peptides are involved in development of duodenal polyps in FAP. but suggests further studies to determine the role of EGF in FAP.",

keywords = "Duodenal polyps, Familial adenomatous polyposis, Regulatory peptides",

author = "Olsen, {Peter Skov} and Steffen B{\"u}low and J{\o}rgensen, {Per N.} and Poulsen, {Steen Seier} and Ebba Nex{\o}",

year = "1990",

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T1 - Gastrointestinal regulatory peptides in familial adenomatous polyposis

AU - Olsen, Peter Skov

AU - Bülow, Steffen

AU - Jørgensen, Per N.

AU - Poulsen, Steen Seier

AU - Nexø, Ebba

PY - 1990/1/1

Y1 - 1990/1/1

N2 - The etiology of adenomas in the stomach and duodenum in patients with familial adenomatous polyposis (FAP) is unknown. In this study the plasma concentration of epidermal growth factor (EGF), and other gastrointestinal polypeptides with a possible trophic effect on the gastrointestinal mucosa, was unchanged before and after meal stimulation. In 3 of 7 patients an increased EGF immunoreactivity was found in duodenal adenomas. This study has not indicated that regulatory peptides are involved in development of duodenal polyps in FAP. but suggests further studies to determine the role of EGF in FAP.

AB - The etiology of adenomas in the stomach and duodenum in patients with familial adenomatous polyposis (FAP) is unknown. In this study the plasma concentration of epidermal growth factor (EGF), and other gastrointestinal polypeptides with a possible trophic effect on the gastrointestinal mucosa, was unchanged before and after meal stimulation. In 3 of 7 patients an increased EGF immunoreactivity was found in duodenal adenomas. This study has not indicated that regulatory peptides are involved in development of duodenal polyps in FAP. but suggests further studies to determine the role of EGF in FAP.

KW - Duodenal polyps

KW - Familial adenomatous polyposis

KW - Regulatory peptides

UR - http://www.scopus.com/inward/record.url?scp=0025641543&partnerID=8YFLogxK

U2 - 10.1159/000200350

DO - 10.1159/000200350

M3 - Journal article

C2 - 2178136

AN - SCOPUS:0025641543

SN - 0012-2823

VL - 46

SP - 228

EP - 232

JO - Digestion

JF - Digestion

IS - 4

ER -

Gastrointestinal regulatory peptides in familial adenomatous polyposis

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Keywords

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