Gastrointestinal regulatory peptides in familial adenomatous polyposis

Peter Skov Olsen; Steffen Bülow; Per N. Jørgensen; Steen Seier Poulsen; Ebba Nexø

doi:10.1159/000200350

Gastrointestinal regulatory peptides in familial adenomatous polyposis

Peter Skov Olsen^*, Steffen Bülow, Per N. Jørgensen, Steen Seier Poulsen, Ebba Nexø

^*Corresponding author af dette arbejde

1 Citationer (Scopus)

Abstract

The etiology of adenomas in the stomach and duodenum in patients with familial adenomatous polyposis (FAP) is unknown. In this study the plasma concentration of epidermal growth factor (EGF), and other gastrointestinal polypeptides with a possible trophic effect on the gastrointestinal mucosa, was unchanged before and after meal stimulation. In 3 of 7 patients an increased EGF immunoreactivity was found in duodenal adenomas. This study has not indicated that regulatory peptides are involved in development of duodenal polyps in FAP. but suggests further studies to determine the role of EGF in FAP.

Originalsprog	Engelsk
Tidsskrift	Digestion
Vol/bind	46
Udgave nummer	4
Sider (fra-til)	228-232
Antal sider	5
ISSN	0012-2823
DOI	https://doi.org/10.1159/000200350
Status	Udgivet - 1 jan. 1990

Adgang til dokumentet

10.1159/000200350

Andre filer og links

Link to publication in Scopus

Citationsformater

@article{9238cab8f06b4aaba184f177aa505338,

title = "Gastrointestinal regulatory peptides in familial adenomatous polyposis",

abstract = "The etiology of adenomas in the stomach and duodenum in patients with familial adenomatous polyposis (FAP) is unknown. In this study the plasma concentration of epidermal growth factor (EGF), and other gastrointestinal polypeptides with a possible trophic effect on the gastrointestinal mucosa, was unchanged before and after meal stimulation. In 3 of 7 patients an increased EGF immunoreactivity was found in duodenal adenomas. This study has not indicated that regulatory peptides are involved in development of duodenal polyps in FAP. but suggests further studies to determine the role of EGF in FAP.",

keywords = "Duodenal polyps, Familial adenomatous polyposis, Regulatory peptides",

author = "Olsen, {Peter Skov} and Steffen B{\"u}low and J{\o}rgensen, {Per N.} and Poulsen, {Steen Seier} and Ebba Nex{\o}",

year = "1990",

month = jan,

day = "1",

doi = "10.1159/000200350",

language = "English",

volume = "46",

pages = "228--232",

journal = "Digestion",

issn = "0012-2823",

publisher = "S Karger AG",

number = "4",

}

TY - JOUR

T1 - Gastrointestinal regulatory peptides in familial adenomatous polyposis

AU - Olsen, Peter Skov

AU - Bülow, Steffen

AU - Jørgensen, Per N.

AU - Poulsen, Steen Seier

AU - Nexø, Ebba

PY - 1990/1/1

Y1 - 1990/1/1

N2 - The etiology of adenomas in the stomach and duodenum in patients with familial adenomatous polyposis (FAP) is unknown. In this study the plasma concentration of epidermal growth factor (EGF), and other gastrointestinal polypeptides with a possible trophic effect on the gastrointestinal mucosa, was unchanged before and after meal stimulation. In 3 of 7 patients an increased EGF immunoreactivity was found in duodenal adenomas. This study has not indicated that regulatory peptides are involved in development of duodenal polyps in FAP. but suggests further studies to determine the role of EGF in FAP.

AB - The etiology of adenomas in the stomach and duodenum in patients with familial adenomatous polyposis (FAP) is unknown. In this study the plasma concentration of epidermal growth factor (EGF), and other gastrointestinal polypeptides with a possible trophic effect on the gastrointestinal mucosa, was unchanged before and after meal stimulation. In 3 of 7 patients an increased EGF immunoreactivity was found in duodenal adenomas. This study has not indicated that regulatory peptides are involved in development of duodenal polyps in FAP. but suggests further studies to determine the role of EGF in FAP.

KW - Duodenal polyps

KW - Familial adenomatous polyposis

KW - Regulatory peptides

UR - http://www.scopus.com/inward/record.url?scp=0025641543&partnerID=8YFLogxK

U2 - 10.1159/000200350

DO - 10.1159/000200350

M3 - Journal article

C2 - 2178136

AN - SCOPUS:0025641543

SN - 0012-2823

VL - 46

SP - 228

EP - 232

JO - Digestion

JF - Digestion

IS - 4

ER -

Gastrointestinal regulatory peptides in familial adenomatous polyposis

Abstract

Adgang til dokumentet

Andre filer og links

Fingeraftryk

Citationsformater