Gap junctions-guards of excitability

TY - JOUR

T1 - Gap junctions-guards of excitability

AU - Stroemlund, Line Waring

AU - Jensen, Christa Funch

AU - Qvortrup, Klaus

AU - Delmar, Mario

AU - Nielsen, Morten Schak

PY - 2015/6/1

Y1 - 2015/6/1

N2 - Cardiomyocytes are connected by mechanical and electrical junctions located at the intercalated discs (IDs). Although these structures have long been known, it is becoming increasingly clear that their components interact. This review describes the involvement of the ID in electrical disturbances of the heart and focuses on the role of the gap junctional protein connexin 43 (Cx43). Current evidence shows that Cx43 plays a crucial role in organizing microtubules at the intercalated disc and thereby regulating the trafficking of the cardiac sodium channel NaV1.5 to the membrane.

AB - Cardiomyocytes are connected by mechanical and electrical junctions located at the intercalated discs (IDs). Although these structures have long been known, it is becoming increasingly clear that their components interact. This review describes the involvement of the ID in electrical disturbances of the heart and focuses on the role of the gap junctional protein connexin 43 (Cx43). Current evidence shows that Cx43 plays a crucial role in organizing microtubules at the intercalated disc and thereby regulating the trafficking of the cardiac sodium channel NaV1.5 to the membrane.

U2 - 10.1042/BST20150059

DO - 10.1042/BST20150059

M3 - Journal article

C2 - 26009199

SN - 0300-5127

VL - 43

SP - 508

EP - 512

JO - Biochemical Society Transactions

JF - Biochemical Society Transactions

IS - 3

ER -