Gap junctions-guards of excitability

Line Waring Stroemlund; Christa Funch Jensen; Klaus Qvortrup; Mario Delmar; Morten Schak Nielsen

doi:10.1042/BST20150059

Gap junctions-guards of excitability

Line Waring Stroemlund, Christa Funch Jensen, Klaus Qvortrup, Mario Delmar, Morten Schak Nielsen

15 Citationer (Scopus)

Abstract

Cardiomyocytes are connected by mechanical and electrical junctions located at the intercalated discs (IDs). Although these structures have long been known, it is becoming increasingly clear that their components interact. This review describes the involvement of the ID in electrical disturbances of the heart and focuses on the role of the gap junctional protein connexin 43 (Cx43). Current evidence shows that Cx43 plays a crucial role in organizing microtubules at the intercalated disc and thereby regulating the trafficking of the cardiac sodium channel NaV1.5 to the membrane.

Originalsprog	Engelsk
Tidsskrift	Biochemical Society Transactions
Vol/bind	43
Udgave nummer	3
Sider (fra-til)	508-12
Antal sider	5
ISSN	0300-5127
DOI	https://doi.org/10.1042/BST20150059
Status	Udgivet - 1 jun. 2015

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10.1042/BST20150059

Citationsformater

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abstract = "Cardiomyocytes are connected by mechanical and electrical junctions located at the intercalated discs (IDs). Although these structures have long been known, it is becoming increasingly clear that their components interact. This review describes the involvement of the ID in electrical disturbances of the heart and focuses on the role of the gap junctional protein connexin 43 (Cx43). Current evidence shows that Cx43 plays a crucial role in organizing microtubules at the intercalated disc and thereby regulating the trafficking of the cardiac sodium channel NaV1.5 to the membrane.",

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AU - Stroemlund, Line Waring

AU - Jensen, Christa Funch

AU - Qvortrup, Klaus

AU - Delmar, Mario

AU - Nielsen, Morten Schak

PY - 2015/6/1

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AB - Cardiomyocytes are connected by mechanical and electrical junctions located at the intercalated discs (IDs). Although these structures have long been known, it is becoming increasingly clear that their components interact. This review describes the involvement of the ID in electrical disturbances of the heart and focuses on the role of the gap junctional protein connexin 43 (Cx43). Current evidence shows that Cx43 plays a crucial role in organizing microtubules at the intercalated disc and thereby regulating the trafficking of the cardiac sodium channel NaV1.5 to the membrane.

U2 - 10.1042/BST20150059

DO - 10.1042/BST20150059

M3 - Journal article

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VL - 43

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Gap junctions-guards of excitability

Abstract

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