Gangliocytic paraganglioma of duodenum metastatic to lymph nodes and liver and extending into the retropancreatic space

TY - JOUR

T1 - Gangliocytic paraganglioma of duodenum metastatic to lymph nodes and liver and extending into the retropancreatic space

AU - Amin, S M

AU - Albrechtsen, N Wewer

AU - Forster, J

AU - Damjanov, I

AU - Albrechtsen, Nicolai Jacob Wewer

PY - 2013/6

Y1 - 2013/6

N2 - Gangliocytic paraganglioma (GP) is a rare benign neuroendocrine tumour found most often in the duodenum. To our knowledge, only a dozen cases of possibly malignant duodenal GP with local lymph node metastasis and only one case with liver metastasis have previously been published. Herein, we report an unusual case of GP of the duodenum spreading to the retropancreatic space and metastatic to the liver and lymph nodes. Additionally, the present tumour secreted pancreatic polypeptide (PP) which was detected in the serum during the follow-up period. We suggest that serum PP could be a valuable marker in the diagnosis and follow-up of patients with GP.

AB - Gangliocytic paraganglioma (GP) is a rare benign neuroendocrine tumour found most often in the duodenum. To our knowledge, only a dozen cases of possibly malignant duodenal GP with local lymph node metastasis and only one case with liver metastasis have previously been published. Herein, we report an unusual case of GP of the duodenum spreading to the retropancreatic space and metastatic to the liver and lymph nodes. Additionally, the present tumour secreted pancreatic polypeptide (PP) which was detected in the serum during the follow-up period. We suggest that serum PP could be a valuable marker in the diagnosis and follow-up of patients with GP.

KW - Biopsy

KW - Duodenal Neoplasms

KW - Humans

KW - Liver Neoplasms

KW - Lymphatic Metastasis

KW - Male

KW - Middle Aged

KW - Paraganglioma

KW - Retroperitoneal Space

M3 - Journal article

C2 - 24047035

SN - 0031-2983

VL - 105

SP - 90

EP - 93

JO - Pathologica

JF - Pathologica

IS - 3

ER -