Frequent genetic differences between matched primary and metastatic breast cancer provide an approach to identification of biomarkers for disease progression

Andrzej B Popławski; Michał Jankowski; Stephen W Erickson; Teresita Díaz de Ståhl; E Christopher Partridge; Chiquito Crasto; Jingyu Guo; John Gibson; Uwe Menzel; Carl Eg Bruder; Aneta Kaczmarczyk; Magdalena Benetkiewicz; Robin Andersson; Johanna Sandgren; Barbara Zegarska; Dariusz Bała; Ewa Srutek; David B Allison; Arkadiusz Piotrowski; Wojciech Zegarski; Jan P Dumanski

doi:10.1038/ejhg.2009.230

Frequent genetic differences between matched primary and metastatic breast cancer provide an approach to identification of biomarkers for disease progression

Andrzej B Popławski, Michał Jankowski, Stephen W Erickson, Teresita Díaz de Ståhl, E Christopher Partridge, Chiquito Crasto, Jingyu Guo, John Gibson, Uwe Menzel, Carl Eg Bruder, Aneta Kaczmarczyk, Magdalena Benetkiewicz, Robin Andersson, Johanna Sandgren, Barbara Zegarska, Dariusz Bała, Ewa Srutek, David B Allison, Arkadiusz Piotrowski, Wojciech ZegarskiJan P Dumanski

43 Citations (Scopus)

Abstract

Breast cancer is a major cause of morbidity and mortality in women and its metastatic spread is the principal reason behind the fatal outcome. Metastasis-related research of breast cancer is however underdeveloped when compared with the abundant literature on primary tumors. We applied an unexplored approach comparing at high resolution the genomic profiles of primary tumors and synchronous axillary lymph node metastases from 13 patients with breast cancer. Overall, primary tumors displayed 20% higher number of aberrations than metastases. In all but two patients, we detected in total 157 statistically significant differences between primary lesions and matched metastases. We further observed differences that can be linked to metastatic disease and there was also an overlapping pattern of changes between different patients. Many of the differences described here have been previously linked to poor patient survival, suggesting that this is a viable approach toward finding biomarkers for disease progression and definition of new targets useful for development of anticancer drugs. Frequent genetic differences between primary tumors and metastases in breast cancer also question, at least to some extent, the role of primary tumors as a surrogate subject of study for the systemic disease.

Original language	English
Journal	European Journal of Human Genetics
Volume	18
Issue number	5
Pages (from-to)	560-8
Number of pages	9
ISSN	1018-4813
DOIs	https://doi.org/10.1038/ejhg.2009.230
Publication status	Published - May 2010
Externally published	Yes

Keywords

Adult
Aged
Breast Neoplasms
Chromosomes, Human, Pair 11
DNA Copy Number Variations
Disease Progression
Female
Gene Expression Profiling
Gene Expression Regulation, Neoplastic
Genome, Human
Humans
Lymphatic Metastasis
Middle Aged
Oligonucleotide Array Sequence Analysis
Tumor Markers, Biological

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1038/ejhg.2009.230

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Popławski, A. B., Jankowski, M., Erickson, S. W., Díaz de Ståhl, T., Partridge, E. C., Crasto, C., Guo, J., Gibson, J., Menzel, U., Bruder, C. E., Kaczmarczyk, A., Benetkiewicz, M., Andersson, R., Sandgren, J., Zegarska, B., Bała, D., Srutek, E., Allison, D. B., Piotrowski, A., ... Dumanski, J. P. (2010). Frequent genetic differences between matched primary and metastatic breast cancer provide an approach to identification of biomarkers for disease progression. European Journal of Human Genetics, 18(5), 560-8. https://doi.org/10.1038/ejhg.2009.230

Frequent genetic differences between matched primary and metastatic breast cancer provide an approach to identification of biomarkers for disease progression. / Popławski, Andrzej B; Jankowski, Michał; Erickson, Stephen W et al.
In: European Journal of Human Genetics, Vol. 18, No. 5, 05.2010, p. 560-8.

Research output: Contribution to journal › Journal article › Research › peer-review

Popławski, AB, Jankowski, M, Erickson, SW, Díaz de Ståhl, T, Partridge, EC, Crasto, C, Guo, J, Gibson, J, Menzel, U, Bruder, CE, Kaczmarczyk, A, Benetkiewicz, M, Andersson, R, Sandgren, J, Zegarska, B, Bała, D, Srutek, E, Allison, DB, Piotrowski, A, Zegarski, W & Dumanski, JP 2010, 'Frequent genetic differences between matched primary and metastatic breast cancer provide an approach to identification of biomarkers for disease progression', European Journal of Human Genetics, vol. 18, no. 5, pp. 560-8. https://doi.org/10.1038/ejhg.2009.230

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abstract = "Breast cancer is a major cause of morbidity and mortality in women and its metastatic spread is the principal reason behind the fatal outcome. Metastasis-related research of breast cancer is however underdeveloped when compared with the abundant literature on primary tumors. We applied an unexplored approach comparing at high resolution the genomic profiles of primary tumors and synchronous axillary lymph node metastases from 13 patients with breast cancer. Overall, primary tumors displayed 20% higher number of aberrations than metastases. In all but two patients, we detected in total 157 statistically significant differences between primary lesions and matched metastases. We further observed differences that can be linked to metastatic disease and there was also an overlapping pattern of changes between different patients. Many of the differences described here have been previously linked to poor patient survival, suggesting that this is a viable approach toward finding biomarkers for disease progression and definition of new targets useful for development of anticancer drugs. Frequent genetic differences between primary tumors and metastases in breast cancer also question, at least to some extent, the role of primary tumors as a surrogate subject of study for the systemic disease.",

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T1 - Frequent genetic differences between matched primary and metastatic breast cancer provide an approach to identification of biomarkers for disease progression

AU - Popławski, Andrzej B

AU - Jankowski, Michał

AU - Erickson, Stephen W

AU - Díaz de Ståhl, Teresita

AU - Partridge, E Christopher

AU - Crasto, Chiquito

AU - Guo, Jingyu

AU - Gibson, John

AU - Menzel, Uwe

AU - Bruder, Carl Eg

AU - Kaczmarczyk, Aneta

AU - Benetkiewicz, Magdalena

AU - Andersson, Robin

AU - Sandgren, Johanna

AU - Zegarska, Barbara

AU - Bała, Dariusz

AU - Srutek, Ewa

AU - Allison, David B

AU - Piotrowski, Arkadiusz

AU - Zegarski, Wojciech

AU - Dumanski, Jan P

PY - 2010/5

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N2 - Breast cancer is a major cause of morbidity and mortality in women and its metastatic spread is the principal reason behind the fatal outcome. Metastasis-related research of breast cancer is however underdeveloped when compared with the abundant literature on primary tumors. We applied an unexplored approach comparing at high resolution the genomic profiles of primary tumors and synchronous axillary lymph node metastases from 13 patients with breast cancer. Overall, primary tumors displayed 20% higher number of aberrations than metastases. In all but two patients, we detected in total 157 statistically significant differences between primary lesions and matched metastases. We further observed differences that can be linked to metastatic disease and there was also an overlapping pattern of changes between different patients. Many of the differences described here have been previously linked to poor patient survival, suggesting that this is a viable approach toward finding biomarkers for disease progression and definition of new targets useful for development of anticancer drugs. Frequent genetic differences between primary tumors and metastases in breast cancer also question, at least to some extent, the role of primary tumors as a surrogate subject of study for the systemic disease.

AB - Breast cancer is a major cause of morbidity and mortality in women and its metastatic spread is the principal reason behind the fatal outcome. Metastasis-related research of breast cancer is however underdeveloped when compared with the abundant literature on primary tumors. We applied an unexplored approach comparing at high resolution the genomic profiles of primary tumors and synchronous axillary lymph node metastases from 13 patients with breast cancer. Overall, primary tumors displayed 20% higher number of aberrations than metastases. In all but two patients, we detected in total 157 statistically significant differences between primary lesions and matched metastases. We further observed differences that can be linked to metastatic disease and there was also an overlapping pattern of changes between different patients. Many of the differences described here have been previously linked to poor patient survival, suggesting that this is a viable approach toward finding biomarkers for disease progression and definition of new targets useful for development of anticancer drugs. Frequent genetic differences between primary tumors and metastases in breast cancer also question, at least to some extent, the role of primary tumors as a surrogate subject of study for the systemic disease.

KW - Adult

KW - Aged

KW - Breast Neoplasms

KW - Chromosomes, Human, Pair 11

KW - DNA Copy Number Variations

KW - Disease Progression

KW - Female

KW - Gene Expression Profiling

KW - Gene Expression Regulation, Neoplastic

KW - Genome, Human

KW - Humans

KW - Lymphatic Metastasis

KW - Middle Aged

KW - Oligonucleotide Array Sequence Analysis

KW - Tumor Markers, Biological

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DO - 10.1038/ejhg.2009.230

M3 - Journal article

C2 - 20051991

SN - 1018-4813

VL - 18

SP - 560

EP - 568

JO - European Journal of Human Genetics

JF - European Journal of Human Genetics

IS - 5

ER -

Frequent genetic differences between matched primary and metastatic breast cancer provide an approach to identification of biomarkers for disease progression

Abstract

Keywords

UN SDGs

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