Frequency of atopy in the Arctic in 1987 and 1998

Tyra Krause; Anders Koch; Jeppe Friborg; Lars K. Poulsen; Bjarne Kristensen; Mads Melbye

Frequency of atopy in the Arctic in 1987 and 1998

Tyra Krause, Anders Koch, Jeppe Friborg, Lars K. Poulsen, Bjarne Kristensen, Mads Melbye

69 Citations (Scopus)

Abstract

Few studies have measured the frequency of atopy with objective measures, and most of these studies have been done in industrialised countries. We analysed serum samples from 859 15-80-year-old Greenlanders who had participated in population-based screening campaigns in 1987 and in 1998. We defined atopy as a positive result in an assay that tests for specific IgE against the eight most common inhalant allergens in one pool (grass, birch, mugwort, dog, cat, horse, Cladosporum herbarum, house dust mite). The frequency of atopy doubled between 1987 (39 [10%] of 392) and 1998 (87 [19%] of 467; risk ratio 1.88 [95% CI 1.31-2.68]). This increase was largest in 15-19-year olds, but also occurred in older people, suggesting that the risk factors responsible for the increase in atopy do not operate only in childhood.

Original language	English
Journal	Lancet
Volume	360
Issue number	9334
Pages (from-to)	691-2
Number of pages	2
ISSN	0140-6736
Publication status	Published - 31 Aug 2002

Keywords

Adolescent
Adult
Age Distribution
Age Factors
Aged
Aged, 80 and over
Allergens
Dermatitis, Atopic
Female
Greenland
Humans
Immunoglobulin E
Male
Mass Screening
Middle Aged
Risk Factors

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title = "Frequency of atopy in the Arctic in 1987 and 1998",

abstract = "Few studies have measured the frequency of atopy with objective measures, and most of these studies have been done in industrialised countries. We analysed serum samples from 859 15-80-year-old Greenlanders who had participated in population-based screening campaigns in 1987 and in 1998. We defined atopy as a positive result in an assay that tests for specific IgE against the eight most common inhalant allergens in one pool (grass, birch, mugwort, dog, cat, horse, Cladosporum herbarum, house dust mite). The frequency of atopy doubled between 1987 (39 [10%] of 392) and 1998 (87 [19%] of 467; risk ratio 1.88 [95% CI 1.31-2.68]). This increase was largest in 15-19-year olds, but also occurred in older people, suggesting that the risk factors responsible for the increase in atopy do not operate only in childhood.",

keywords = "Adolescent, Adult, Age Distribution, Age Factors, Aged, Aged, 80 and over, Allergens, Dermatitis, Atopic, Female, Greenland, Humans, Immunoglobulin E, Male, Mass Screening, Middle Aged, Risk Factors",

author = "Tyra Krause and Anders Koch and Jeppe Friborg and Poulsen, {Lars K.} and Bjarne Kristensen and Mads Melbye",

year = "2002",

month = aug,

day = "31",

language = "English",

volume = "360",

pages = "691--2",

journal = "Lancet",

issn = "0140-6736",

publisher = "TheLancet Publishing Group",

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TY - JOUR

T1 - Frequency of atopy in the Arctic in 1987 and 1998

AU - Krause, Tyra

AU - Koch, Anders

AU - Friborg, Jeppe

AU - Poulsen, Lars K.

AU - Kristensen, Bjarne

AU - Melbye, Mads

PY - 2002/8/31

Y1 - 2002/8/31

N2 - Few studies have measured the frequency of atopy with objective measures, and most of these studies have been done in industrialised countries. We analysed serum samples from 859 15-80-year-old Greenlanders who had participated in population-based screening campaigns in 1987 and in 1998. We defined atopy as a positive result in an assay that tests for specific IgE against the eight most common inhalant allergens in one pool (grass, birch, mugwort, dog, cat, horse, Cladosporum herbarum, house dust mite). The frequency of atopy doubled between 1987 (39 [10%] of 392) and 1998 (87 [19%] of 467; risk ratio 1.88 [95% CI 1.31-2.68]). This increase was largest in 15-19-year olds, but also occurred in older people, suggesting that the risk factors responsible for the increase in atopy do not operate only in childhood.

AB - Few studies have measured the frequency of atopy with objective measures, and most of these studies have been done in industrialised countries. We analysed serum samples from 859 15-80-year-old Greenlanders who had participated in population-based screening campaigns in 1987 and in 1998. We defined atopy as a positive result in an assay that tests for specific IgE against the eight most common inhalant allergens in one pool (grass, birch, mugwort, dog, cat, horse, Cladosporum herbarum, house dust mite). The frequency of atopy doubled between 1987 (39 [10%] of 392) and 1998 (87 [19%] of 467; risk ratio 1.88 [95% CI 1.31-2.68]). This increase was largest in 15-19-year olds, but also occurred in older people, suggesting that the risk factors responsible for the increase in atopy do not operate only in childhood.

KW - Adolescent

KW - Adult

KW - Age Distribution

KW - Age Factors

KW - Aged

KW - Aged, 80 and over

KW - Allergens

KW - Dermatitis, Atopic

KW - Female

KW - Greenland

KW - Humans

KW - Immunoglobulin E

KW - Male

KW - Mass Screening

KW - Middle Aged

KW - Risk Factors

M3 - Journal article

C2 - 12241878

SN - 0140-6736

VL - 360

SP - 691

EP - 692

JO - Lancet

JF - Lancet

IS - 9334

ER -

Frequency of atopy in the Arctic in 1987 and 1998

Abstract

Keywords

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