Frequency of atopy in the Arctic in 1987 and 1998

Tyra Krause; Anders Koch; Jeppe Friborg; Lars K. Poulsen; Bjarne Kristensen; Mads Melbye

Frequency of atopy in the Arctic in 1987 and 1998

Tyra Krause, Anders Koch, Jeppe Friborg, Lars K. Poulsen, Bjarne Kristensen, Mads Melbye

69 Citationer (Scopus)

Abstract

Few studies have measured the frequency of atopy with objective measures, and most of these studies have been done in industrialised countries. We analysed serum samples from 859 15-80-year-old Greenlanders who had participated in population-based screening campaigns in 1987 and in 1998. We defined atopy as a positive result in an assay that tests for specific IgE against the eight most common inhalant allergens in one pool (grass, birch, mugwort, dog, cat, horse, Cladosporum herbarum, house dust mite). The frequency of atopy doubled between 1987 (39 [10%] of 392) and 1998 (87 [19%] of 467; risk ratio 1.88 [95% CI 1.31-2.68]). This increase was largest in 15-19-year olds, but also occurred in older people, suggesting that the risk factors responsible for the increase in atopy do not operate only in childhood.

Originalsprog	Engelsk
Tidsskrift	Lancet
Vol/bind	360
Udgave nummer	9334
Sider (fra-til)	691-2
Antal sider	2
ISSN	0140-6736
Status	Udgivet - 31 aug. 2002

Citationsformater

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title = "Frequency of atopy in the Arctic in 1987 and 1998",

abstract = "Few studies have measured the frequency of atopy with objective measures, and most of these studies have been done in industrialised countries. We analysed serum samples from 859 15-80-year-old Greenlanders who had participated in population-based screening campaigns in 1987 and in 1998. We defined atopy as a positive result in an assay that tests for specific IgE against the eight most common inhalant allergens in one pool (grass, birch, mugwort, dog, cat, horse, Cladosporum herbarum, house dust mite). The frequency of atopy doubled between 1987 (39 [10%] of 392) and 1998 (87 [19%] of 467; risk ratio 1.88 [95% CI 1.31-2.68]). This increase was largest in 15-19-year olds, but also occurred in older people, suggesting that the risk factors responsible for the increase in atopy do not operate only in childhood.",

keywords = "Adolescent, Adult, Age Distribution, Age Factors, Aged, Aged, 80 and over, Allergens, Dermatitis, Atopic, Female, Greenland, Humans, Immunoglobulin E, Male, Mass Screening, Middle Aged, Risk Factors",

author = "Tyra Krause and Anders Koch and Jeppe Friborg and Poulsen, {Lars K.} and Bjarne Kristensen and Mads Melbye",

year = "2002",

month = aug,

day = "31",

language = "English",

volume = "360",

pages = "691--2",

journal = "Lancet",

issn = "0140-6736",

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TY - JOUR

T1 - Frequency of atopy in the Arctic in 1987 and 1998

AU - Krause, Tyra

AU - Koch, Anders

AU - Friborg, Jeppe

AU - Poulsen, Lars K.

AU - Kristensen, Bjarne

AU - Melbye, Mads

PY - 2002/8/31

Y1 - 2002/8/31

N2 - Few studies have measured the frequency of atopy with objective measures, and most of these studies have been done in industrialised countries. We analysed serum samples from 859 15-80-year-old Greenlanders who had participated in population-based screening campaigns in 1987 and in 1998. We defined atopy as a positive result in an assay that tests for specific IgE against the eight most common inhalant allergens in one pool (grass, birch, mugwort, dog, cat, horse, Cladosporum herbarum, house dust mite). The frequency of atopy doubled between 1987 (39 [10%] of 392) and 1998 (87 [19%] of 467; risk ratio 1.88 [95% CI 1.31-2.68]). This increase was largest in 15-19-year olds, but also occurred in older people, suggesting that the risk factors responsible for the increase in atopy do not operate only in childhood.

AB - Few studies have measured the frequency of atopy with objective measures, and most of these studies have been done in industrialised countries. We analysed serum samples from 859 15-80-year-old Greenlanders who had participated in population-based screening campaigns in 1987 and in 1998. We defined atopy as a positive result in an assay that tests for specific IgE against the eight most common inhalant allergens in one pool (grass, birch, mugwort, dog, cat, horse, Cladosporum herbarum, house dust mite). The frequency of atopy doubled between 1987 (39 [10%] of 392) and 1998 (87 [19%] of 467; risk ratio 1.88 [95% CI 1.31-2.68]). This increase was largest in 15-19-year olds, but also occurred in older people, suggesting that the risk factors responsible for the increase in atopy do not operate only in childhood.

KW - Adolescent

KW - Adult

KW - Age Distribution

KW - Age Factors

KW - Aged

KW - Aged, 80 and over

KW - Allergens

KW - Dermatitis, Atopic

KW - Female

KW - Greenland

KW - Humans

KW - Immunoglobulin E

KW - Male

KW - Mass Screening

KW - Middle Aged

KW - Risk Factors

M3 - Journal article

C2 - 12241878

SN - 0140-6736

VL - 360

SP - 691

EP - 692

JO - Lancet

JF - Lancet

IS - 9334

ER -

Frequency of atopy in the Arctic in 1987 and 1998

Abstract

Fingeraftryk

Citationsformater