Formulation of RNA interference-based drugs for pulmonary delivery: challenges and opportunities

Kaushik Thanki; Kevin G Blum; Aneesh Thakur; Fabrice Rose; Camilla Foged

doi:10.4155/tde-2018-0029

Formulation of RNA interference-based drugs for pulmonary delivery: challenges and opportunities

Kaushik Thanki, Kevin G Blum, Aneesh Thakur, Fabrice Rose, Camilla Foged

7 Citations (Scopus)

Abstract

With recent advances in the field of RNAi-based therapeutics, it is possible to make any target gene 'druggable', at least in principle. The present review focuses on aspects critical for pulmonary delivery of formulations of nucleic acid-based drugs. The first part introduces the therapeutic potential of RNAi-based drugs for the treatment of lung diseases. Subsequently, we discuss opportunities for formulation-enabled pulmonary delivery of RNAi drugs in light of key physicochemical properties and physiological barriers. In the following section, an overview is included of methodologies for imparting inhalable characteristics to nucleic acid formulations. Finally, we review one of the bottlenecks in the early preclinical testing of inhalable nucleic acid-based formulations, in other words, devices suitable for pulmonary administration of powder-based formulations in rodents.

Original language	English
Journal	Therapeutic Delivery
Volume	9
Issue number	10
Pages (from-to)	731-749
Number of pages	19
ISSN	2041-5990
DOIs	https://doi.org/10.4155/tde-2018-0029
Publication status	Published - Oct 2018

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title = "Formulation of RNA interference-based drugs for pulmonary delivery: challenges and opportunities",

abstract = "With recent advances in the field of RNAi-based therapeutics, it is possible to make any target gene 'druggable', at least in principle. The present review focuses on aspects critical for pulmonary delivery of formulations of nucleic acid-based drugs. The first part introduces the therapeutic potential of RNAi-based drugs for the treatment of lung diseases. Subsequently, we discuss opportunities for formulation-enabled pulmonary delivery of RNAi drugs in light of key physicochemical properties and physiological barriers. In the following section, an overview is included of methodologies for imparting inhalable characteristics to nucleic acid formulations. Finally, we review one of the bottlenecks in the early preclinical testing of inhalable nucleic acid-based formulations, in other words, devices suitable for pulmonary administration of powder-based formulations in rodents.",

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AU - Rose, Fabrice

AU - Foged, Camilla

PY - 2018/10

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AB - With recent advances in the field of RNAi-based therapeutics, it is possible to make any target gene 'druggable', at least in principle. The present review focuses on aspects critical for pulmonary delivery of formulations of nucleic acid-based drugs. The first part introduces the therapeutic potential of RNAi-based drugs for the treatment of lung diseases. Subsequently, we discuss opportunities for formulation-enabled pulmonary delivery of RNAi drugs in light of key physicochemical properties and physiological barriers. In the following section, an overview is included of methodologies for imparting inhalable characteristics to nucleic acid formulations. Finally, we review one of the bottlenecks in the early preclinical testing of inhalable nucleic acid-based formulations, in other words, devices suitable for pulmonary administration of powder-based formulations in rodents.

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JO - Therapeutic Delivery

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Formulation of RNA interference-based drugs for pulmonary delivery: challenges and opportunities

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