Forensic and phylogeographic characterisation of mtDNA lineages from Somalia

Martin Mikkelsen; Liane Fendt; Alexander W. Röck; Bettina Zimmermann; Eszter Rockenbauer; Anders Johannes Hansen; Walther Parson; Niels Morling

doi:10.1007/s00414-012-0694-6

Forensic and phylogeographic characterisation of mtDNA lineages from Somalia

Martin Mikkelsen, Liane Fendt, Alexander W. Röck, Bettina Zimmermann, Eszter Rockenbauer, Anders Johannes Hansen, Walther Parson, Niels Morling

14 Citations (Scopus)

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Abstract

The African mitochondrial (mt) phylogeny is coarsely resolved but the majority of population data generated so far is limited to the analysis of the first hypervariable segment (HVS-1) of the control region (CR). Therefore, this study aimed on the investigation of the entire CR of 190 unrelated Somali individuals to enrich the severely underrepresented African mtDNA pool. The majority (60.5 %) of the haplotypes were of sub-Saharan origin with L0a1d, L2a1h and L3f being the most frequently observed haplogroups. This is in sharp contrast to previous data reported from the Y-chromosome, where only about 5 % of the observed haplogroups were of sub-Saharan provenance. We compared the genetic distances based on population pairwise F (st) values between 11 published East, Central and North African as well as western Asian populations and the Somali sequences and displayed them in a multi-dimensional scaling plot. Genetic proximity evidenced by clustering roughly reflected the relative geographic location of the populations. The sequences will be included in the EMPOP database ( www.empop.org ) under accession number EMP00397 upon publication (Parson and Dür Forensic Sci Int Genet 1:88-92, 2007).

Original language	English
Journal	International Journal of Legal Medicine
Volume	126
Issue number	4
Pages (from-to)	573-579
Number of pages	7
ISSN	0937-9827
DOIs	https://doi.org/10.1007/s00414-012-0694-6
Publication status	Published - Jul 2012

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title = "Forensic and phylogeographic characterisation of mtDNA lineages from Somalia",

abstract = "The African mitochondrial (mt) phylogeny is coarsely resolved but the majority of population data generated so far is limited to the analysis of the first hypervariable segment (HVS-1) of the control region (CR). Therefore, this study aimed on the investigation of the entire CR of 190 unrelated Somali individuals to enrich the severely underrepresented African mtDNA pool. The majority (60.5 %) of the haplotypes were of sub-Saharan origin with L0a1d, L2a1h and L3f being the most frequently observed haplogroups. This is in sharp contrast to previous data reported from the Y-chromosome, where only about 5 % of the observed haplogroups were of sub-Saharan provenance. We compared the genetic distances based on population pairwise F (st) values between 11 published East, Central and North African as well as western Asian populations and the Somali sequences and displayed them in a multi-dimensional scaling plot. Genetic proximity evidenced by clustering roughly reflected the relative geographic location of the populations. The sequences will be included in the EMPOP database ( www.empop.org ) under accession number EMP00397 upon publication (Parson and D{\"u}r Forensic Sci Int Genet 1:88-92, 2007).",

author = "Martin Mikkelsen and Liane Fendt and R{\"o}ck, {Alexander W.} and Bettina Zimmermann and Eszter Rockenbauer and Hansen, {Anders Johannes} and Walther Parson and Niels Morling",

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T1 - Forensic and phylogeographic characterisation of mtDNA lineages from Somalia

AU - Mikkelsen, Martin

AU - Fendt, Liane

AU - Röck, Alexander W.

AU - Zimmermann, Bettina

AU - Rockenbauer, Eszter

AU - Hansen, Anders Johannes

AU - Parson, Walther

AU - Morling, Niels

PY - 2012/7

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N2 - The African mitochondrial (mt) phylogeny is coarsely resolved but the majority of population data generated so far is limited to the analysis of the first hypervariable segment (HVS-1) of the control region (CR). Therefore, this study aimed on the investigation of the entire CR of 190 unrelated Somali individuals to enrich the severely underrepresented African mtDNA pool. The majority (60.5 %) of the haplotypes were of sub-Saharan origin with L0a1d, L2a1h and L3f being the most frequently observed haplogroups. This is in sharp contrast to previous data reported from the Y-chromosome, where only about 5 % of the observed haplogroups were of sub-Saharan provenance. We compared the genetic distances based on population pairwise F (st) values between 11 published East, Central and North African as well as western Asian populations and the Somali sequences and displayed them in a multi-dimensional scaling plot. Genetic proximity evidenced by clustering roughly reflected the relative geographic location of the populations. The sequences will be included in the EMPOP database ( www.empop.org ) under accession number EMP00397 upon publication (Parson and Dür Forensic Sci Int Genet 1:88-92, 2007).

AB - The African mitochondrial (mt) phylogeny is coarsely resolved but the majority of population data generated so far is limited to the analysis of the first hypervariable segment (HVS-1) of the control region (CR). Therefore, this study aimed on the investigation of the entire CR of 190 unrelated Somali individuals to enrich the severely underrepresented African mtDNA pool. The majority (60.5 %) of the haplotypes were of sub-Saharan origin with L0a1d, L2a1h and L3f being the most frequently observed haplogroups. This is in sharp contrast to previous data reported from the Y-chromosome, where only about 5 % of the observed haplogroups were of sub-Saharan provenance. We compared the genetic distances based on population pairwise F (st) values between 11 published East, Central and North African as well as western Asian populations and the Somali sequences and displayed them in a multi-dimensional scaling plot. Genetic proximity evidenced by clustering roughly reflected the relative geographic location of the populations. The sequences will be included in the EMPOP database ( www.empop.org ) under accession number EMP00397 upon publication (Parson and Dür Forensic Sci Int Genet 1:88-92, 2007).

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DO - 10.1007/s00414-012-0694-6

M3 - Journal article

C2 - 22527188

SN - 0937-9827

VL - 126

SP - 573

EP - 579

JO - International Journal of Legal Medicine

JF - International Journal of Legal Medicine

IS - 4

ER -

Forensic and phylogeographic characterisation of mtDNA lineages from Somalia

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