Flow-mediated vasodilation measurements in Cavalier King Charles Spaniels with increasing severity of myxomatous mitral valve disease

Sophia Gry Moesgaard; Charlotte Klostergaard Løwert; Nora Elisabeth Zois; T. Teerlink; M. Molin; Bo Torkel Falk; Caroline Elisabeth Rasmussen; V. Luis Fuentes; I.D. Jones; Lisbeth Høier Olsen

doi:10.1111/j.1939-1676.2011.00846.x

Flow-mediated vasodilation measurements in Cavalier King Charles Spaniels with increasing severity of myxomatous mitral valve disease

Sophia Gry Moesgaard, Charlotte Klostergaard Løwert, Nora Elisabeth Zois, T. Teerlink, M. Molin, Bo Torkel Falk, Caroline Elisabeth Rasmussen, V. Luis Fuentes, I.D. Jones, Lisbeth Høier Olsen

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14 Citations (Scopus)

Abstract

Background: Cardiovascular disease is associated with endothelial dysfunction in humans and studies of plasma biomarkers suggest that dogs with myxomatous mitral valve disease (MMVD) might also have endothelial dysfunction. Hypothesis: That progression of mitral regurgitation (MR) is associated with development of endothelial dysfunction. Animals: Forty-three Cavalier King Charles Spaniels (CKCS) with MR of varying severity. Methods: Privately owned CKCS were prospectively recruited and divided in 4 groups: (1) 12 CKCS with minimal MR; (2) 9 CKCS with mild MR; (3) 11 CKCS with moderate-severe MR; and (4) 11 CKCS with moderate-severe MR and clinical signs compatible with heart failure. Dogs underwent blood sampling, echocardiography, blood pressure (BP) recordings, and flow-mediated vasodilation (FMD) measurements. The effect of progressive MR on FMD was determined by multivariate analyses. Results: Flow-mediated vasodilation decreased with progression of MR. Group 4 (4.79 ± 3.22%) had significantly lower FMD than groups 1 (10.40 ± 4.58%) and 2 (10.14 ± 3.67%) (P < .005) and group 3 (6.79 ± 3.98%) had a significantly lower FMD than group 1 (P = .03). Increasing left ventricular end-diastolic diameter (P = .0004, R ² = 0.27) and the combination of age (P = .01) and body weight (P = .002) (R ² = 0.31) were significantly associated with reduced FMD. FMD did not correlate with sex, BP, or plasma markers. Conclusions and Clinical Importance: Reduced FMD indicates that increased disease severity in CKCS with MMVD is associated with development of endothelial dysfunction which might be a future therapeutic and/or diagnostic target.

Original language	English
Journal	Journal of Veterinary Internal Medicine
Volume	26
Issue number	1
Pages (from-to)	61-68
Number of pages	8
ISSN	0891-6640
DOIs	https://doi.org/10.1111/j.1939-1676.2011.00846.x
Publication status	Published - Jan 2012

Keywords

Animals
Arginine
Blood Pressure
Dog Diseases
Dogs
Echocardiography
Endothelium, Vascular
Female
Male
Mitral Valve Insufficiency
Vasodilation

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1111/j.1939-1676.2011.00846.x

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Moesgaard, S. G., Løwert, C. K., Zois, N. E., Teerlink, T., Molin, M., Falk, B. T., Rasmussen, C. E., Fuentes, V. L., Jones, I. D., & Olsen, L. H. (2012). Flow-mediated vasodilation measurements in Cavalier King Charles Spaniels with increasing severity of myxomatous mitral valve disease. Journal of Veterinary Internal Medicine, 26(1), 61-68. https://doi.org/10.1111/j.1939-1676.2011.00846.x

Flow-mediated vasodilation measurements in Cavalier King Charles Spaniels with increasing severity of myxomatous mitral valve disease. / Moesgaard, Sophia Gry; Løwert, Charlotte Klostergaard; Zois, Nora Elisabeth et al.
In: Journal of Veterinary Internal Medicine, Vol. 26, No. 1, 01.2012, p. 61-68.

Research output: Contribution to journal › Journal article › Research › peer-review

Moesgaard, SG, Løwert, CK, Zois, NE, Teerlink, T, Molin, M, Falk, BT, Rasmussen, CE, Fuentes, VL, Jones, ID & Olsen, LH 2012, 'Flow-mediated vasodilation measurements in Cavalier King Charles Spaniels with increasing severity of myxomatous mitral valve disease', Journal of Veterinary Internal Medicine, vol. 26, no. 1, pp. 61-68. https://doi.org/10.1111/j.1939-1676.2011.00846.x

@article{6e67af0f3b4c45e3a5c46121f840d5e0,

title = "Flow-mediated vasodilation measurements in Cavalier King Charles Spaniels with increasing severity of myxomatous mitral valve disease",

abstract = "Background: Cardiovascular disease is associated with endothelial dysfunction in humans and studies of plasma biomarkers suggest that dogs with myxomatous mitral valve disease (MMVD) might also have endothelial dysfunction. Hypothesis: That progression of mitral regurgitation (MR) is associated with development of endothelial dysfunction. Animals: Forty-three Cavalier King Charles Spaniels (CKCS) with MR of varying severity. Methods: Privately owned CKCS were prospectively recruited and divided in 4 groups: (1) 12 CKCS with minimal MR; (2) 9 CKCS with mild MR; (3) 11 CKCS with moderate-severe MR; and (4) 11 CKCS with moderate-severe MR and clinical signs compatible with heart failure. Dogs underwent blood sampling, echocardiography, blood pressure (BP) recordings, and flow-mediated vasodilation (FMD) measurements. The effect of progressive MR on FMD was determined by multivariate analyses. Results: Flow-mediated vasodilation decreased with progression of MR. Group 4 (4.79 ± 3.22%) had significantly lower FMD than groups 1 (10.40 ± 4.58%) and 2 (10.14 ± 3.67%) (P < .005) and group 3 (6.79 ± 3.98%) had a significantly lower FMD than group 1 (P = .03). Increasing left ventricular end-diastolic diameter (P = .0004, R 2 = 0.27) and the combination of age (P = .01) and body weight (P = .002) (R 2 = 0.31) were significantly associated with reduced FMD. FMD did not correlate with sex, BP, or plasma markers. Conclusions and Clinical Importance: Reduced FMD indicates that increased disease severity in CKCS with MMVD is associated with development of endothelial dysfunction which might be a future therapeutic and/or diagnostic target.",

keywords = "Animals, Arginine, Blood Pressure, Dog Diseases, Dogs, Echocardiography, Endothelium, Vascular, Female, Male, Mitral Valve Insufficiency, Vasodilation, Asymmetric dimethylarginine, Dog, Endothelial dysfunction",

author = "Moesgaard, {Sophia Gry} and L{\o}wert, {Charlotte Klostergaard} and Zois, {Nora Elisabeth} and T. Teerlink and M. Molin and Falk, {Bo Torkel} and Rasmussen, {Caroline Elisabeth} and Fuentes, {V. Luis} and I.D. Jones and Olsen, {Lisbeth H{\o}ier}",

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doi = "10.1111/j.1939-1676.2011.00846.x",

language = "English",

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pages = "61--68",

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T1 - Flow-mediated vasodilation measurements in Cavalier King Charles Spaniels with increasing severity of myxomatous mitral valve disease

AU - Moesgaard, Sophia Gry

AU - Løwert, Charlotte Klostergaard

AU - Zois, Nora Elisabeth

AU - Teerlink, T.

AU - Molin, M.

AU - Falk, Bo Torkel

AU - Rasmussen, Caroline Elisabeth

AU - Fuentes, V. Luis

AU - Jones, I.D.

AU - Olsen, Lisbeth Høier

PY - 2012/1

Y1 - 2012/1

N2 - Background: Cardiovascular disease is associated with endothelial dysfunction in humans and studies of plasma biomarkers suggest that dogs with myxomatous mitral valve disease (MMVD) might also have endothelial dysfunction. Hypothesis: That progression of mitral regurgitation (MR) is associated with development of endothelial dysfunction. Animals: Forty-three Cavalier King Charles Spaniels (CKCS) with MR of varying severity. Methods: Privately owned CKCS were prospectively recruited and divided in 4 groups: (1) 12 CKCS with minimal MR; (2) 9 CKCS with mild MR; (3) 11 CKCS with moderate-severe MR; and (4) 11 CKCS with moderate-severe MR and clinical signs compatible with heart failure. Dogs underwent blood sampling, echocardiography, blood pressure (BP) recordings, and flow-mediated vasodilation (FMD) measurements. The effect of progressive MR on FMD was determined by multivariate analyses. Results: Flow-mediated vasodilation decreased with progression of MR. Group 4 (4.79 ± 3.22%) had significantly lower FMD than groups 1 (10.40 ± 4.58%) and 2 (10.14 ± 3.67%) (P < .005) and group 3 (6.79 ± 3.98%) had a significantly lower FMD than group 1 (P = .03). Increasing left ventricular end-diastolic diameter (P = .0004, R 2 = 0.27) and the combination of age (P = .01) and body weight (P = .002) (R 2 = 0.31) were significantly associated with reduced FMD. FMD did not correlate with sex, BP, or plasma markers. Conclusions and Clinical Importance: Reduced FMD indicates that increased disease severity in CKCS with MMVD is associated with development of endothelial dysfunction which might be a future therapeutic and/or diagnostic target.

AB - Background: Cardiovascular disease is associated with endothelial dysfunction in humans and studies of plasma biomarkers suggest that dogs with myxomatous mitral valve disease (MMVD) might also have endothelial dysfunction. Hypothesis: That progression of mitral regurgitation (MR) is associated with development of endothelial dysfunction. Animals: Forty-three Cavalier King Charles Spaniels (CKCS) with MR of varying severity. Methods: Privately owned CKCS were prospectively recruited and divided in 4 groups: (1) 12 CKCS with minimal MR; (2) 9 CKCS with mild MR; (3) 11 CKCS with moderate-severe MR; and (4) 11 CKCS with moderate-severe MR and clinical signs compatible with heart failure. Dogs underwent blood sampling, echocardiography, blood pressure (BP) recordings, and flow-mediated vasodilation (FMD) measurements. The effect of progressive MR on FMD was determined by multivariate analyses. Results: Flow-mediated vasodilation decreased with progression of MR. Group 4 (4.79 ± 3.22%) had significantly lower FMD than groups 1 (10.40 ± 4.58%) and 2 (10.14 ± 3.67%) (P < .005) and group 3 (6.79 ± 3.98%) had a significantly lower FMD than group 1 (P = .03). Increasing left ventricular end-diastolic diameter (P = .0004, R 2 = 0.27) and the combination of age (P = .01) and body weight (P = .002) (R 2 = 0.31) were significantly associated with reduced FMD. FMD did not correlate with sex, BP, or plasma markers. Conclusions and Clinical Importance: Reduced FMD indicates that increased disease severity in CKCS with MMVD is associated with development of endothelial dysfunction which might be a future therapeutic and/or diagnostic target.

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KW - Arginine

KW - Blood Pressure

KW - Dog Diseases

KW - Dogs

KW - Echocardiography

KW - Endothelium, Vascular

KW - Female

KW - Male

KW - Mitral Valve Insufficiency

KW - Vasodilation

KW - Asymmetric dimethylarginine

KW - Dog

KW - Endothelial dysfunction

U2 - 10.1111/j.1939-1676.2011.00846.x

DO - 10.1111/j.1939-1676.2011.00846.x

M3 - Journal article

C2 - 22151409

SN - 0891-6640

VL - 26

SP - 61

EP - 68

JO - Journal of Veterinary Internal Medicine

JF - Journal of Veterinary Internal Medicine

IS - 1

ER -

Flow-mediated vasodilation measurements in Cavalier King Charles Spaniels with increasing severity of myxomatous mitral valve disease

Abstract

Keywords

UN SDGs

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