Fibrosis and Cancer: Partners in Crime or Opposing Forces?

Thomas R. Cox; Janine T. Erler

doi:10.1016/j.trecan.2016.05.004

Fibrosis and Cancer: Partners in Crime or Opposing Forces?

Thomas R. Cox^*, Janine T. Erler

^*Corresponding author for this work

25 Citations (Scopus)

Abstract

The relation between fibrosis and cancer has long been debated, specifically whether desmoplasia precedes, accompanies, or succeeds tumourigenesis, progression, and metastasis. Recent reports have published opposing data, adding to the perplexity. However, what is emerging is that it is likely the specific properties of the extracellular matrix (ECM) that determine the paradoxical nature of cancer-associated fibrosis.

Original language	English
Journal	Trends in Cancer
Volume	2
Issue number	6
Pages (from-to)	279-282
Number of pages	4
ISSN	2405-8033
DOIs	https://doi.org/10.1016/j.trecan.2016.05.004
Publication status	Published - 2016

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10.1016/j.trecan.2016.05.004

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title = "Fibrosis and Cancer: Partners in Crime or Opposing Forces?",

abstract = "The relation between fibrosis and cancer has long been debated, specifically whether desmoplasia precedes, accompanies, or succeeds tumourigenesis, progression, and metastasis. Recent reports have published opposing data, adding to the perplexity. However, what is emerging is that it is likely the specific properties of the extracellular matrix (ECM) that determine the paradoxical nature of cancer-associated fibrosis.",

author = "Cox, {Thomas R.} and Erler, {Janine T.}",

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T2 - Partners in Crime or Opposing Forces?

AU - Cox, Thomas R.

AU - Erler, Janine T.

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AB - The relation between fibrosis and cancer has long been debated, specifically whether desmoplasia precedes, accompanies, or succeeds tumourigenesis, progression, and metastasis. Recent reports have published opposing data, adding to the perplexity. However, what is emerging is that it is likely the specific properties of the extracellular matrix (ECM) that determine the paradoxical nature of cancer-associated fibrosis.

U2 - 10.1016/j.trecan.2016.05.004

DO - 10.1016/j.trecan.2016.05.004

M3 - Review

C2 - 28741525

AN - SCOPUS:84974824035

SN - 2405-8033

VL - 2

SP - 279

EP - 282

JO - Trends in Cancer

JF - Trends in Cancer

IS - 6

ER -

Fibrosis and Cancer: Partners in Crime or Opposing Forces?

Abstract

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