Fibrosis and Cancer: Partners in Crime or Opposing Forces?

TY - JOUR

T1 - Fibrosis and Cancer

T2 - Partners in Crime or Opposing Forces?

AU - Cox, Thomas R.

AU - Erler, Janine T.

PY - 2016

Y1 - 2016

N2 - The relation between fibrosis and cancer has long been debated, specifically whether desmoplasia precedes, accompanies, or succeeds tumourigenesis, progression, and metastasis. Recent reports have published opposing data, adding to the perplexity. However, what is emerging is that it is likely the specific properties of the extracellular matrix (ECM) that determine the paradoxical nature of cancer-associated fibrosis.

AB - The relation between fibrosis and cancer has long been debated, specifically whether desmoplasia precedes, accompanies, or succeeds tumourigenesis, progression, and metastasis. Recent reports have published opposing data, adding to the perplexity. However, what is emerging is that it is likely the specific properties of the extracellular matrix (ECM) that determine the paradoxical nature of cancer-associated fibrosis.

U2 - 10.1016/j.trecan.2016.05.004

DO - 10.1016/j.trecan.2016.05.004

M3 - Review

C2 - 28741525

AN - SCOPUS:84974824035

SN - 2405-8033

VL - 2

SP - 279

EP - 282

JO - Trends in Cancer

JF - Trends in Cancer

IS - 6

ER -