FGF21 Is a Sugar-Induced Hormone Associated with Sweet Intake and Preference in Humans

Susanna Søberg; Camilla Helene Sandholt; Naja  Z. Jespersen; Ulla Toft; Anja  L. Madsen; Stephanie Ø von Holstein-Rathlou; Trisha Jean Grevengoed; Karl Bang Christensen; Wender Bredie; Matthew J Potthoff; Thomas P. J. Solomon; Camilla Charlotte Schéele; Allan René Linneberg; Torben Jørgensen; Oluf Borbye Pedersen; Torben Hansen; Matthew Paul Gillum; Niels Grarup

doi:10.1016/j.cmet.2017.04.009

FGF21 Is a Sugar-Induced Hormone Associated with Sweet Intake and Preference in Humans

Susanna Søberg, Camilla Helene Sandholt, Naja Z. Jespersen, Ulla Toft, Anja L. Madsen, Stephanie Ø von Holstein-Rathlou, Trisha Jean Grevengoed, Karl Bang Christensen, Wender Bredie, Matthew J Potthoff, Thomas P. J. Solomon, Camilla Charlotte Schéele, Allan René Linneberg, Torben Jørgensen, Oluf Borbye Pedersen, Torben Hansen, Matthew Paul Gillum, Niels Grarup

88 Citations (Scopus)

Abstract

The liking and selective ingestion of palatable foods—including sweets—is biologically controlled, and dysfunction of this regulation may promote unhealthy eating, obesity, and disease. The hepatokine fibroblast growth factor 21 (FGF21) reduces sweet consumption in rodents and primates, whereas knockout of Fgf21 increases sugar consumption in mice. To investigate the relevance of these findings in humans, we genotyped variants in the FGF21 locus in participants from the Danish Inter99 cohort (n = 6,514) and examined their relationship with a detailed range of food and ingestive behaviors. This revealed statistically significant associations between FGF21 rs838133 and increased consumption of candy, as well as nominal associations with increased alcohol intake and daily smoking. Moreover, in a separate clinical study, plasma FGF21 levels increased acutely after oral sucrose ingestion and were elevated in fasted sweet-disliking individuals. These data suggest the liver may secrete hormones that influence eating behavior.

Original language	English
Journal	Cell Metabolism
Volume	25
Issue number	5
Pages (from-to)	1045-1053
Number of pages	9
ISSN	1550-4131
DOIs	https://doi.org/10.1016/j.cmet.2017.04.009
Publication status	Published - 2 May 2017

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1016/j.cmet.2017.04.009

http://www.cell.com/article/S1550413117302140/pdf

Cite this

Søberg, S., Sandholt, C. H., Z. Jespersen, N., Toft, U., L. Madsen, A., von Holstein-Rathlou, S. Ø., Grevengoed, T. J., Christensen, K. B., Bredie, W., Potthoff, M. J., P. J. Solomon, T., Schéele, C. C., Linneberg, A. R., Jørgensen, T., Pedersen, O. B., Hansen, T., Gillum, M. P., & Grarup, N. (2017). FGF21 Is a Sugar-Induced Hormone Associated with Sweet Intake and Preference in Humans. Cell Metabolism, 25(5), 1045-1053. https://doi.org/10.1016/j.cmet.2017.04.009

Søberg, S, Sandholt, CH, Z. Jespersen, N, Toft, U, L. Madsen, A, von Holstein-Rathlou, SØ , Grevengoed, TJ , Christensen, KB , Bredie, W, Potthoff, MJ, P. J. Solomon, T, Schéele, CC , Linneberg, AR, Jørgensen, T, Pedersen, OB , Hansen, T , Gillum, MP & Grarup, N 2017, 'FGF21 Is a Sugar-Induced Hormone Associated with Sweet Intake and Preference in Humans', Cell Metabolism, vol. 25, no. 5, pp. 1045-1053. https://doi.org/10.1016/j.cmet.2017.04.009

@article{6a2b27d85d224f28ae945a57d6e27ea3,

title = "FGF21 Is a Sugar-Induced Hormone Associated with Sweet Intake and Preference in Humans",

abstract = "The liking and selective ingestion of palatable foods—including sweets—is biologically controlled, and dysfunction of this regulation may promote unhealthy eating, obesity, and disease. The hepatokine fibroblast growth factor 21 (FGF21) reduces sweet consumption in rodents and primates, whereas knockout of Fgf21 increases sugar consumption in mice. To investigate the relevance of these findings in humans, we genotyped variants in the FGF21 locus in participants from the Danish Inter99 cohort (n = 6,514) and examined their relationship with a detailed range of food and ingestive behaviors. This revealed statistically significant associations between FGF21 rs838133 and increased consumption of candy, as well as nominal associations with increased alcohol intake and daily smoking. Moreover, in a separate clinical study, plasma FGF21 levels increased acutely after oral sucrose ingestion and were elevated in fasted sweet-disliking individuals. These data suggest the liver may secrete hormones that influence eating behavior.",

author = "Susanna S{\o}berg and Sandholt, {Camilla Helene} and {Z. Jespersen}, Naja and Ulla Toft and {L. Madsen}, Anja and {von Holstein-Rathlou}, {Stephanie {\O}} and Grevengoed, {Trisha Jean} and Christensen, {Karl Bang} and Wender Bredie and Potthoff, {Matthew J} and {P. J. Solomon}, Thomas and Sch{\'e}ele, {Camilla Charlotte} and Linneberg, {Allan Ren{\'e}} and Torben J{\o}rgensen and Pedersen, {Oluf Borbye} and Torben Hansen and Gillum, {Matthew Paul} and Niels Grarup",

year = "2017",

month = may,

day = "2",

doi = "10.1016/j.cmet.2017.04.009",

language = "English",

volume = "25",

pages = "1045--1053",

journal = "Cell Metabolism",

issn = "1550-4131",

publisher = "Cell Press",

number = "5",

}

TY - JOUR

T1 - FGF21 Is a Sugar-Induced Hormone Associated with Sweet Intake and Preference in Humans

AU - Søberg, Susanna

AU - Sandholt, Camilla Helene

AU - Z. Jespersen, Naja

AU - Toft, Ulla

AU - L. Madsen, Anja

AU - von Holstein-Rathlou, Stephanie Ø

AU - Grevengoed, Trisha Jean

AU - Christensen, Karl Bang

AU - Bredie, Wender

AU - Potthoff, Matthew J

AU - P. J. Solomon, Thomas

AU - Schéele, Camilla Charlotte

AU - Linneberg, Allan René

AU - Jørgensen, Torben

AU - Pedersen, Oluf Borbye

AU - Hansen, Torben

AU - Gillum, Matthew Paul

AU - Grarup, Niels

PY - 2017/5/2

Y1 - 2017/5/2

N2 - The liking and selective ingestion of palatable foods—including sweets—is biologically controlled, and dysfunction of this regulation may promote unhealthy eating, obesity, and disease. The hepatokine fibroblast growth factor 21 (FGF21) reduces sweet consumption in rodents and primates, whereas knockout of Fgf21 increases sugar consumption in mice. To investigate the relevance of these findings in humans, we genotyped variants in the FGF21 locus in participants from the Danish Inter99 cohort (n = 6,514) and examined their relationship with a detailed range of food and ingestive behaviors. This revealed statistically significant associations between FGF21 rs838133 and increased consumption of candy, as well as nominal associations with increased alcohol intake and daily smoking. Moreover, in a separate clinical study, plasma FGF21 levels increased acutely after oral sucrose ingestion and were elevated in fasted sweet-disliking individuals. These data suggest the liver may secrete hormones that influence eating behavior.

AB - The liking and selective ingestion of palatable foods—including sweets—is biologically controlled, and dysfunction of this regulation may promote unhealthy eating, obesity, and disease. The hepatokine fibroblast growth factor 21 (FGF21) reduces sweet consumption in rodents and primates, whereas knockout of Fgf21 increases sugar consumption in mice. To investigate the relevance of these findings in humans, we genotyped variants in the FGF21 locus in participants from the Danish Inter99 cohort (n = 6,514) and examined their relationship with a detailed range of food and ingestive behaviors. This revealed statistically significant associations between FGF21 rs838133 and increased consumption of candy, as well as nominal associations with increased alcohol intake and daily smoking. Moreover, in a separate clinical study, plasma FGF21 levels increased acutely after oral sucrose ingestion and were elevated in fasted sweet-disliking individuals. These data suggest the liver may secrete hormones that influence eating behavior.

U2 - 10.1016/j.cmet.2017.04.009

DO - 10.1016/j.cmet.2017.04.009

M3 - Journal article

C2 - 28467924

SN - 1550-4131

VL - 25

SP - 1045

EP - 1053

JO - Cell Metabolism

JF - Cell Metabolism

IS - 5

ER -

FGF21 Is a Sugar-Induced Hormone Associated with Sweet Intake and Preference in Humans

Abstract

UN SDGs

Access to Document

Fingerprint

Cite this