FGF-2 low molecular weight selectively promotes neuritogenesis of motor neurons in vitro

Ilary Allodi; Laura Casals-Díaz; Eva Santos-Nogueira; Francisco Gonzalez-Perez; Xavier Navarro; Esther Udina

doi:10.1007/s12035-012-8389-z

FGF-2 low molecular weight selectively promotes neuritogenesis of motor neurons in vitro

Ilary Allodi, Laura Casals-Díaz, Eva Santos-Nogueira, Francisco Gonzalez-Perez, Xavier Navarro, Esther Udina

Motor Control

15 Citations (Scopus)

Abstract

In this study, we screened in vitro the different capabilities of trophic factors with promising effect for enhancing selective regeneration and thus promoting specific reinnervation of target organs after peripheral nerve regeneration. We found that FGF-2 (18 kDa) was the trophic factor that exerted the most selective effect in promoting neurite outgrowth of spinal motoneurons both in terms of elongation and arborization. The mechanism underlying this effect on neuritogenesis seems related to FGF-2 enhancing the interaction between FGFR-1 and PSA-NCAM. The interaction of these two receptors is important during the early stages of neuritogenesis and pathfinding, while integrin alpha7B subunit seems to play a role during neurite stabilization.

Original language	English
Journal	Molecular Neurobiology
Volume	47
Issue number	2
Pages (from-to)	770-781
Number of pages	12
ISSN	0893-7648
DOIs	https://doi.org/10.1007/s12035-012-8389-z
Publication status	Published - Apr 2013

Keywords

Animals
Animals, Newborn
Cells, Cultured
Female
Fibroblast Growth Factor 2/pharmacology
Ganglia, Spinal/cytology
Motor Neurons/cytology
Neurites/drug effects
Neurogenesis/drug effects
Organ Culture Techniques
Rats
Rats, Sprague-Dawley
Spinal Cord/cytology

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10.1007/s12035-012-8389-z

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title = "FGF-2 low molecular weight selectively promotes neuritogenesis of motor neurons in vitro",

abstract = "In this study, we screened in vitro the different capabilities of trophic factors with promising effect for enhancing selective regeneration and thus promoting specific reinnervation of target organs after peripheral nerve regeneration. We found that FGF-2 (18 kDa) was the trophic factor that exerted the most selective effect in promoting neurite outgrowth of spinal motoneurons both in terms of elongation and arborization. The mechanism underlying this effect on neuritogenesis seems related to FGF-2 enhancing the interaction between FGFR-1 and PSA-NCAM. The interaction of these two receptors is important during the early stages of neuritogenesis and pathfinding, while integrin alpha7B subunit seems to play a role during neurite stabilization.",

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author = "Ilary Allodi and Laura Casals-D{\'i}az and Eva Santos-Nogueira and Francisco Gonzalez-Perez and Xavier Navarro and Esther Udina",

year = "2013",

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doi = "10.1007/s12035-012-8389-z",

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T1 - FGF-2 low molecular weight selectively promotes neuritogenesis of motor neurons in vitro

AU - Allodi, Ilary

AU - Casals-Díaz, Laura

AU - Santos-Nogueira, Eva

AU - Gonzalez-Perez, Francisco

AU - Navarro, Xavier

AU - Udina, Esther

PY - 2013/4

Y1 - 2013/4

N2 - In this study, we screened in vitro the different capabilities of trophic factors with promising effect for enhancing selective regeneration and thus promoting specific reinnervation of target organs after peripheral nerve regeneration. We found that FGF-2 (18 kDa) was the trophic factor that exerted the most selective effect in promoting neurite outgrowth of spinal motoneurons both in terms of elongation and arborization. The mechanism underlying this effect on neuritogenesis seems related to FGF-2 enhancing the interaction between FGFR-1 and PSA-NCAM. The interaction of these two receptors is important during the early stages of neuritogenesis and pathfinding, while integrin alpha7B subunit seems to play a role during neurite stabilization.

AB - In this study, we screened in vitro the different capabilities of trophic factors with promising effect for enhancing selective regeneration and thus promoting specific reinnervation of target organs after peripheral nerve regeneration. We found that FGF-2 (18 kDa) was the trophic factor that exerted the most selective effect in promoting neurite outgrowth of spinal motoneurons both in terms of elongation and arborization. The mechanism underlying this effect on neuritogenesis seems related to FGF-2 enhancing the interaction between FGFR-1 and PSA-NCAM. The interaction of these two receptors is important during the early stages of neuritogenesis and pathfinding, while integrin alpha7B subunit seems to play a role during neurite stabilization.

KW - Animals

KW - Animals, Newborn

KW - Cells, Cultured

KW - Female

KW - Fibroblast Growth Factor 2/pharmacology

KW - Ganglia, Spinal/cytology

KW - Motor Neurons/cytology

KW - Neurites/drug effects

KW - Neurogenesis/drug effects

KW - Organ Culture Techniques

KW - Rats

KW - Rats, Sprague-Dawley

KW - Spinal Cord/cytology

U2 - 10.1007/s12035-012-8389-z

DO - 10.1007/s12035-012-8389-z

M3 - Journal article

C2 - 23275175

SN - 0893-7648

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SP - 770

EP - 781

JO - Molecular Neurobiology

JF - Molecular Neurobiology

IS - 2

ER -

FGF-2 low molecular weight selectively promotes neuritogenesis of motor neurons in vitro

Abstract

Keywords

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