Extra-cerebral oxygenation influence on near-infrared-spectroscopy-determined frontal lobe oxygenation in healthy volunteers: a comparison between INVOS-4100 and NIRO-200NX

TY - JOUR

T1 - Extra-cerebral oxygenation influence on near-infrared-spectroscopy-determined frontal lobe oxygenation in healthy volunteers

T2 - a comparison between INVOS-4100 and NIRO-200NX

AU - Sørensen, Henrik

AU - Rasmussen, Peter

AU - Siebenmann, Christoph

AU - Zaar, Morten

AU - Hvidtfeldt, Morten

AU - Ogoh, Shigehiko

AU - Sato, Kohei

AU - Kohl-Bareis, Matthias

AU - Secher, Niels H

AU - Lundby, Carsten

N1 - © 2014 Scandinavian Society of Clinical Physiology and Nuclear Medicine. Published by John Wiley & Sons Ltd.

PY - 2015/5/1

Y1 - 2015/5/1

N2 - Introduction: Frontal lobe oxygenation (ScO2) is assessed by spatially resolved near-infrared spectroscopy (SR-NIRS) although it seems influenced by extra-cerebral oxygenation. We aimed to quantify the impact of extra-cerebral oxygenation on two SR-NIRS derived ScO2. Methods: Multiple regression analysis estimated the influence of extra-cerebral oxygenation as exemplified by skin oxygenation (SskinO2) on ScO2 in 21 healthy subjects exposed to whole-body exercise in hypoxia (FiO2 = 12%; n = 10) and normoxia (n = 12), whole-body heating, hyperventilation (n = 21), administration of norepinephrine with and without petCO2-correction (n = 15), phenylephrine and head-up tilt (n = 7). ScO2 was assessed simultaneously by NIRO-200NX (SniroO2) and INVOS-4100 (SinvosO2). Arterial (SaO2) and jugular bulb oxygen saturations (SjO2) were obtained. Results: The regression analysis indicated that SinvosO2 reflects 46% arterial, 14% jugular, 35% skin and 4% oxygenation of tissues not interrogated. SinvosO2 follows a calculated estimate of cerebral capillary oxygenation (r = 0·67; P<0·0001). In contrast, the NIRO-200NX-determined ScO2 did not correlate with the estimate of cerebral oxygenation (r = 0·026; P = 0·71). Conclusion: For all interventions, 35% of the INVOS-4100 signal reflected extra-cerebral oxygenation while, on the other hand, NIRO-200NX did not follow changes in a calculated estimate of cerebral capillary oxygenation. Thus, the NIRO-200NX and INVOS-4100 do not provide for unbiased evaluation of the cerebral signal.

AB - Introduction: Frontal lobe oxygenation (ScO2) is assessed by spatially resolved near-infrared spectroscopy (SR-NIRS) although it seems influenced by extra-cerebral oxygenation. We aimed to quantify the impact of extra-cerebral oxygenation on two SR-NIRS derived ScO2. Methods: Multiple regression analysis estimated the influence of extra-cerebral oxygenation as exemplified by skin oxygenation (SskinO2) on ScO2 in 21 healthy subjects exposed to whole-body exercise in hypoxia (FiO2 = 12%; n = 10) and normoxia (n = 12), whole-body heating, hyperventilation (n = 21), administration of norepinephrine with and without petCO2-correction (n = 15), phenylephrine and head-up tilt (n = 7). ScO2 was assessed simultaneously by NIRO-200NX (SniroO2) and INVOS-4100 (SinvosO2). Arterial (SaO2) and jugular bulb oxygen saturations (SjO2) were obtained. Results: The regression analysis indicated that SinvosO2 reflects 46% arterial, 14% jugular, 35% skin and 4% oxygenation of tissues not interrogated. SinvosO2 follows a calculated estimate of cerebral capillary oxygenation (r = 0·67; P<0·0001). In contrast, the NIRO-200NX-determined ScO2 did not correlate with the estimate of cerebral oxygenation (r = 0·026; P = 0·71). Conclusion: For all interventions, 35% of the INVOS-4100 signal reflected extra-cerebral oxygenation while, on the other hand, NIRO-200NX did not follow changes in a calculated estimate of cerebral capillary oxygenation. Thus, the NIRO-200NX and INVOS-4100 do not provide for unbiased evaluation of the cerebral signal.

U2 - 10.1111/cpf.12142

DO - 10.1111/cpf.12142

M3 - Journal article

C2 - 24618369

SN - 1475-0961

VL - 35

SP - 177

EP - 184

JO - Clinical Physiology and Functional Imaging

JF - Clinical Physiology and Functional Imaging

IS - 3

ER -