Abstract
Both mammary gland development and mammary carcinogenesis involve extensive remodeling of the mammary gland extracellular matrix. The expression of four membrane-type matrix metalloproteinases (MT-MMPs) with matrix remodeling potential in development and tumorigenesis was evaluated by in-situ hybridization on mouse mammary gland sections. MT1-MMP and MT3-MMP were found in the mammary stroma mainly around epithelial structures in both developing and mature mammary gland. In contrast, MT2-MMP was found exclusively in the mammary epithelium. Lactating gland expressed none of the examined MT-MMPs. Mammary gland tumors expressed MT1-MMP, MT2-MMP, and MT3-MMP while MT4-MMP was not expressed in any developmental or cancerous stage analyzed here. Our results suggest that MT1-MMP, MT2-MMP, and MT3-MMP may be involved in remodeling of both the normal and diseased mammary gland either directly or indirectly by activation of other MMPs.
| Original language | English |
|---|---|
| Journal | Journal of Cellular Physiology |
| Volume | 205 |
| Issue number | 1 |
| Pages (from-to) | 123-32 |
| Number of pages | 10 |
| ISSN | 0021-9541 |
| DOIs | |
| Publication status | Published - Oct 2005 |
Keywords
- Aging/physiology
- Animals
- Female
- Gene Expression Profiling
- Gene Expression Regulation, Enzymologic/genetics
- Health
- Lactation/genetics
- Mammary Glands, Animal/cytology
- Mammary Neoplasms, Animal/enzymology
- Matrix Metalloproteinase 14
- Matrix Metalloproteinase 15
- Matrix Metalloproteinase 16
- Matrix Metalloproteinases, Membrane-Associated
- Metalloendopeptidases/chemistry
- Mice
- Pregnancy
