Expression of nitric oxide synthases and effects of L-arginine and L-NMMA on nitric oxide production and fluid transport in collagenous colitis

A Perner; Lars Andresen; M Normark; B Fischer-Hansen; S Sørensen; J Eugen-Olsen; J Rask-Madsen

Expression of nitric oxide synthases and effects of L-arginine and L-NMMA on nitric oxide production and fluid transport in collagenous colitis

A Perner, Lars Andresen, M Normark, B Fischer-Hansen, S Sørensen, J Eugen-Olsen, J Rask-Madsen

63 Citations (Scopus)

Abstract

Luminal nitric oxide (NO) is greatly increased in the colon of patients with collagenous and ulcerative colitis. To define the source and consequence of enhanced NO production we have studied expression of NO synthase (NOS) isoforms and nitrotyrosine in mucosal biopsies from these patients. In addition, effects on colonic fluid transfer caused by manipulating the substrate of NOS were studied in patients with collagenous colitis.

Original language	English
Journal	Gut
Volume	49
Issue number	3
Pages (from-to)	387-94
Number of pages	8
ISSN	0017-5749
Publication status	Published - 2001

Keywords

Adult
Aged
Arginine
Blotting, Western
Body Fluids
Case-Control Studies
Colitis, Ulcerative
Confidence Intervals
Female
Humans
Intestinal Absorption
Male
Middle Aged
Nitric Oxide
Nitric Oxide Synthase
Nitric Oxide Synthase Type I
Nitric Oxide Synthase Type II
Nitric Oxide Synthase Type III
Statistics, Nonparametric
Tyrosine
Up-Regulation
omega-N-Methylarginine

Cite this

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title = "Expression of nitric oxide synthases and effects of L-arginine and L-NMMA on nitric oxide production and fluid transport in collagenous colitis",

abstract = "Luminal nitric oxide (NO) is greatly increased in the colon of patients with collagenous and ulcerative colitis. To define the source and consequence of enhanced NO production we have studied expression of NO synthase (NOS) isoforms and nitrotyrosine in mucosal biopsies from these patients. In addition, effects on colonic fluid transfer caused by manipulating the substrate of NOS were studied in patients with collagenous colitis.",

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author = "A Perner and Lars Andresen and M Normark and B Fischer-Hansen and S S{\o}rensen and J Eugen-Olsen and J Rask-Madsen",

year = "2001",

language = "English",

volume = "49",

pages = "387--94",

journal = "Gut",

issn = "0017-5749",

publisher = "B M J Group",

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TY - JOUR

T1 - Expression of nitric oxide synthases and effects of L-arginine and L-NMMA on nitric oxide production and fluid transport in collagenous colitis

AU - Perner, A

AU - Andresen, Lars

AU - Normark, M

AU - Fischer-Hansen, B

AU - Sørensen, S

AU - Eugen-Olsen, J

AU - Rask-Madsen, J

PY - 2001

Y1 - 2001

N2 - Luminal nitric oxide (NO) is greatly increased in the colon of patients with collagenous and ulcerative colitis. To define the source and consequence of enhanced NO production we have studied expression of NO synthase (NOS) isoforms and nitrotyrosine in mucosal biopsies from these patients. In addition, effects on colonic fluid transfer caused by manipulating the substrate of NOS were studied in patients with collagenous colitis.

AB - Luminal nitric oxide (NO) is greatly increased in the colon of patients with collagenous and ulcerative colitis. To define the source and consequence of enhanced NO production we have studied expression of NO synthase (NOS) isoforms and nitrotyrosine in mucosal biopsies from these patients. In addition, effects on colonic fluid transfer caused by manipulating the substrate of NOS were studied in patients with collagenous colitis.

KW - Adult

KW - Aged

KW - Arginine

KW - Blotting, Western

KW - Body Fluids

KW - Case-Control Studies

KW - Colitis, Ulcerative

KW - Confidence Intervals

KW - Female

KW - Humans

KW - Intestinal Absorption

KW - Male

KW - Middle Aged

KW - Nitric Oxide

KW - Nitric Oxide Synthase

KW - Nitric Oxide Synthase Type I

KW - Nitric Oxide Synthase Type II

KW - Nitric Oxide Synthase Type III

KW - Statistics, Nonparametric

KW - Tyrosine

KW - Up-Regulation

KW - omega-N-Methylarginine

M3 - Journal article

C2 - 11511561

SN - 0017-5749

VL - 49

SP - 387

EP - 394

JO - Gut

JF - Gut

IS - 3

ER -

Expression of nitric oxide synthases and effects of L-arginine and L-NMMA on nitric oxide production and fluid transport in collagenous colitis

Abstract

Keywords

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