Expression of nitric oxide synthases and effects of L-arginine and L-NMMA on nitric oxide production and fluid transport in collagenous colitis

A Perner, Lars Andresen, M Normark, B Fischer-Hansen, S Sørensen, J Eugen-Olsen, J Rask-Madsen

    63 Citationer (Scopus)

    Abstract

    Luminal nitric oxide (NO) is greatly increased in the colon of patients with collagenous and ulcerative colitis. To define the source and consequence of enhanced NO production we have studied expression of NO synthase (NOS) isoforms and nitrotyrosine in mucosal biopsies from these patients. In addition, effects on colonic fluid transfer caused by manipulating the substrate of NOS were studied in patients with collagenous colitis.
    OriginalsprogEngelsk
    TidsskriftGut
    Vol/bind49
    Udgave nummer3
    Sider (fra-til)387-94
    Antal sider8
    ISSN0017-5749
    StatusUdgivet - 2001

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