Experimental quadriceps muscle pain impairs knee joint control during walking

Marius Henriksen; Tine Alkjaer; Hans Lund; Erik B Simonsen; Thomas Graven-Nielsen; Bente Danneskiold-Samsøe; Henning Bliddal

doi:10.1152/japplphysiol.01105.2006

Experimental quadriceps muscle pain impairs knee joint control during walking

Marius Henriksen, Tine Alkjaer, Hans Lund, Erik B Simonsen, Thomas Graven-Nielsen, Bente Danneskiold-Samsøe, Henning Bliddal

Department of Neuroscience

66 Citations (Scopus)

Abstract

Pain is a cardinal symptom in musculoskeletal diseases involving the knee joint, and aberrant movement patterns and motor control strategies are often present in these patients. However, the underlying neuromuscular mechanisms linking pain to movement and motor control are unclear. To investigate the functional significance of muscle pain on knee joint control during walking, three-dimensional gait analyses were performed before, during, and after experimentally induced muscle pain by means of intramuscular injections of hypertonic saline (5.8%) into vastus medialis (VM) muscle of 20 healthy subjects. Isotonic saline (0.9%) was used as control. Surface electromyography (EMG) recordings of VM, vastus lateralis (VL), biceps femoris, and semitendinosus muscles were synchronized with the gait analyses. During experimental muscle pain, the loading response phase peak knee extensor moments were attenuated, and EMG activity in the VM and VL muscles was reduced. Compressive forces, adduction moments, knee joint kinematics, and hamstring EMG activity were unaffected by pain. Interestingly, the observed changes persisted when the pain had vanished. The results demonstrate that muscle pain modulated the function of the quadriceps muscle, resulting in impaired knee joint control and joint instability during walking. The changes are similar to those observed in patients with knee pain. The loss of joint control during and after pain may leave the knee joint prone to injury and potentially participate in the chronicity of musculoskeletal problems, and it may have clinically important implications for rehabilitation and training of patients with knee pain of musculoskeletal origin.

Original language	English
Journal	Journal of Applied Physiology
Volume	103
Issue number	1
Pages (from-to)	132-9
Number of pages	7
ISSN	8750-7587
DOIs	https://doi.org/10.1152/japplphysiol.01105.2006
Publication status	Published - 2007

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10.1152/japplphysiol.01105.2006

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title = "Experimental quadriceps muscle pain impairs knee joint control during walking",

abstract = "Pain is a cardinal symptom in musculoskeletal diseases involving the knee joint, and aberrant movement patterns and motor control strategies are often present in these patients. However, the underlying neuromuscular mechanisms linking pain to movement and motor control are unclear. To investigate the functional significance of muscle pain on knee joint control during walking, three-dimensional gait analyses were performed before, during, and after experimentally induced muscle pain by means of intramuscular injections of hypertonic saline (5.8%) into vastus medialis (VM) muscle of 20 healthy subjects. Isotonic saline (0.9%) was used as control. Surface electromyography (EMG) recordings of VM, vastus lateralis (VL), biceps femoris, and semitendinosus muscles were synchronized with the gait analyses. During experimental muscle pain, the loading response phase peak knee extensor moments were attenuated, and EMG activity in the VM and VL muscles was reduced. Compressive forces, adduction moments, knee joint kinematics, and hamstring EMG activity were unaffected by pain. Interestingly, the observed changes persisted when the pain had vanished. The results demonstrate that muscle pain modulated the function of the quadriceps muscle, resulting in impaired knee joint control and joint instability during walking. The changes are similar to those observed in patients with knee pain. The loss of joint control during and after pain may leave the knee joint prone to injury and potentially participate in the chronicity of musculoskeletal problems, and it may have clinically important implications for rehabilitation and training of patients with knee pain of musculoskeletal origin.",

author = "Marius Henriksen and Tine Alkjaer and Hans Lund and Simonsen, {Erik B} and Thomas Graven-Nielsen and Bente Danneskiold-Sams{\o}e and Henning Bliddal",

note = "Keywords: Adult; Biomechanics; Cross-Over Studies; Electromyography; Female; Gait; Humans; Injections, Intramuscular; Isotonic Solutions; Joint Instability; Knee Joint; Male; Motor Skills; Muscular Diseases; Pain; Pain Measurement; Quadriceps Muscle; Research Design; Saline Solution, Hypertonic; Sodium Chloride; Walking",

year = "2007",

doi = "10.1152/japplphysiol.01105.2006",

language = "English",

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pages = "132--9",

journal = "Journal of Applied Physiology",

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publisher = "American Physiological Society",

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TY - JOUR

T1 - Experimental quadriceps muscle pain impairs knee joint control during walking

AU - Henriksen, Marius

AU - Alkjaer, Tine

AU - Lund, Hans

AU - Simonsen, Erik B

AU - Graven-Nielsen, Thomas

AU - Danneskiold-Samsøe, Bente

AU - Bliddal, Henning

N1 - Keywords: Adult; Biomechanics; Cross-Over Studies; Electromyography; Female; Gait; Humans; Injections, Intramuscular; Isotonic Solutions; Joint Instability; Knee Joint; Male; Motor Skills; Muscular Diseases; Pain; Pain Measurement; Quadriceps Muscle; Research Design; Saline Solution, Hypertonic; Sodium Chloride; Walking

PY - 2007

Y1 - 2007

N2 - Pain is a cardinal symptom in musculoskeletal diseases involving the knee joint, and aberrant movement patterns and motor control strategies are often present in these patients. However, the underlying neuromuscular mechanisms linking pain to movement and motor control are unclear. To investigate the functional significance of muscle pain on knee joint control during walking, three-dimensional gait analyses were performed before, during, and after experimentally induced muscle pain by means of intramuscular injections of hypertonic saline (5.8%) into vastus medialis (VM) muscle of 20 healthy subjects. Isotonic saline (0.9%) was used as control. Surface electromyography (EMG) recordings of VM, vastus lateralis (VL), biceps femoris, and semitendinosus muscles were synchronized with the gait analyses. During experimental muscle pain, the loading response phase peak knee extensor moments were attenuated, and EMG activity in the VM and VL muscles was reduced. Compressive forces, adduction moments, knee joint kinematics, and hamstring EMG activity were unaffected by pain. Interestingly, the observed changes persisted when the pain had vanished. The results demonstrate that muscle pain modulated the function of the quadriceps muscle, resulting in impaired knee joint control and joint instability during walking. The changes are similar to those observed in patients with knee pain. The loss of joint control during and after pain may leave the knee joint prone to injury and potentially participate in the chronicity of musculoskeletal problems, and it may have clinically important implications for rehabilitation and training of patients with knee pain of musculoskeletal origin.

AB - Pain is a cardinal symptom in musculoskeletal diseases involving the knee joint, and aberrant movement patterns and motor control strategies are often present in these patients. However, the underlying neuromuscular mechanisms linking pain to movement and motor control are unclear. To investigate the functional significance of muscle pain on knee joint control during walking, three-dimensional gait analyses were performed before, during, and after experimentally induced muscle pain by means of intramuscular injections of hypertonic saline (5.8%) into vastus medialis (VM) muscle of 20 healthy subjects. Isotonic saline (0.9%) was used as control. Surface electromyography (EMG) recordings of VM, vastus lateralis (VL), biceps femoris, and semitendinosus muscles were synchronized with the gait analyses. During experimental muscle pain, the loading response phase peak knee extensor moments were attenuated, and EMG activity in the VM and VL muscles was reduced. Compressive forces, adduction moments, knee joint kinematics, and hamstring EMG activity were unaffected by pain. Interestingly, the observed changes persisted when the pain had vanished. The results demonstrate that muscle pain modulated the function of the quadriceps muscle, resulting in impaired knee joint control and joint instability during walking. The changes are similar to those observed in patients with knee pain. The loss of joint control during and after pain may leave the knee joint prone to injury and potentially participate in the chronicity of musculoskeletal problems, and it may have clinically important implications for rehabilitation and training of patients with knee pain of musculoskeletal origin.

U2 - 10.1152/japplphysiol.01105.2006

DO - 10.1152/japplphysiol.01105.2006

M3 - Journal article

C2 - 17412791

SN - 8750-7587

VL - 103

SP - 132

EP - 139

JO - Journal of Applied Physiology

JF - Journal of Applied Physiology

IS - 1

ER -

Experimental quadriceps muscle pain impairs knee joint control during walking

Abstract

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