Expedient protocol for solid-phase synthesis of secondary and tertiary amines

Christian A Olsen; Matthias Witt; Jerzy W Jaroszewski; Henrik Franzyk

doi:10.1021/ol049575h

Expedient protocol for solid-phase synthesis of secondary and tertiary amines

Christian A Olsen, Matthias Witt, Jerzy W Jaroszewski, Henrik Franzyk

22 Citations (Scopus)

Abstract

[reaction: see text] An expedient solid-phase synthetic approach to secondary and tertiary amines was developed. The protocol employs conversion of resin-bound amino alcohols to the corresponding iodides, followed by iodide displacement with primary or secondary amines or with unprotected amino alcohols. This two-step procedure, affording products in good to excellent yields, is suitable for solid-phase synthesis of polyamines.

Original language	English
Journal	Organic Letters
Volume	6
Issue number	12
Pages (from-to)	1935-8
Number of pages	4
ISSN	1523-7060
DOIs	https://doi.org/10.1021/ol049575h
Publication status	Published - 2004

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10.1021/ol049575h

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title = "Expedient protocol for solid-phase synthesis of secondary and tertiary amines",

abstract = "[reaction: see text] An expedient solid-phase synthetic approach to secondary and tertiary amines was developed. The protocol employs conversion of resin-bound amino alcohols to the corresponding iodides, followed by iodide displacement with primary or secondary amines or with unprotected amino alcohols. This two-step procedure, affording products in good to excellent yields, is suitable for solid-phase synthesis of polyamines.",

author = "Olsen, {Christian A} and Matthias Witt and Jaroszewski, {Jerzy W} and Henrik Franzyk",

year = "2004",

doi = "10.1021/ol049575h",

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journal = "Organic Letters",

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T1 - Expedient protocol for solid-phase synthesis of secondary and tertiary amines

AU - Olsen, Christian A

AU - Witt, Matthias

AU - Jaroszewski, Jerzy W

AU - Franzyk, Henrik

PY - 2004

Y1 - 2004

N2 - [reaction: see text] An expedient solid-phase synthetic approach to secondary and tertiary amines was developed. The protocol employs conversion of resin-bound amino alcohols to the corresponding iodides, followed by iodide displacement with primary or secondary amines or with unprotected amino alcohols. This two-step procedure, affording products in good to excellent yields, is suitable for solid-phase synthesis of polyamines.

AB - [reaction: see text] An expedient solid-phase synthetic approach to secondary and tertiary amines was developed. The protocol employs conversion of resin-bound amino alcohols to the corresponding iodides, followed by iodide displacement with primary or secondary amines or with unprotected amino alcohols. This two-step procedure, affording products in good to excellent yields, is suitable for solid-phase synthesis of polyamines.

U2 - 10.1021/ol049575h

DO - 10.1021/ol049575h

M3 - Journal article

C2 - 15176787

SN - 1523-7060

VL - 6

SP - 1935

EP - 1938

JO - Organic Letters

JF - Organic Letters

IS - 12

ER -

Expedient protocol for solid-phase synthesis of secondary and tertiary amines

Abstract

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