Expedient protocol for solid-phase synthesis of secondary and tertiary amines

TY - JOUR

T1 - Expedient protocol for solid-phase synthesis of secondary and tertiary amines

AU - Olsen, Christian A

AU - Witt, Matthias

AU - Jaroszewski, Jerzy W

AU - Franzyk, Henrik

PY - 2004

Y1 - 2004

N2 - [reaction: see text] An expedient solid-phase synthetic approach to secondary and tertiary amines was developed. The protocol employs conversion of resin-bound amino alcohols to the corresponding iodides, followed by iodide displacement with primary or secondary amines or with unprotected amino alcohols. This two-step procedure, affording products in good to excellent yields, is suitable for solid-phase synthesis of polyamines.

AB - [reaction: see text] An expedient solid-phase synthetic approach to secondary and tertiary amines was developed. The protocol employs conversion of resin-bound amino alcohols to the corresponding iodides, followed by iodide displacement with primary or secondary amines or with unprotected amino alcohols. This two-step procedure, affording products in good to excellent yields, is suitable for solid-phase synthesis of polyamines.

U2 - 10.1021/ol049575h

DO - 10.1021/ol049575h

M3 - Journal article

C2 - 15176787

SN - 1523-7060

VL - 6

SP - 1935

EP - 1938

JO - Organic Letters

JF - Organic Letters

IS - 12

ER -