Exercise Promotes Healthy Aging of Skeletal Muscle

Gregory D Cartee; Russell T Hepple; Marcas M Bamman; Juleen R Zierath

doi:10.1016/j.cmet.2016.05.007

Exercise Promotes Healthy Aging of Skeletal Muscle

Gregory D Cartee, Russell T Hepple, Marcas M Bamman, Juleen R Zierath

166 Citations (Scopus)

Abstract

Primary aging is the progressive and inevitable process of bodily deterioration during adulthood. In skeletal muscle, primary aging causes defective mitochondrial energetics and reduced muscle mass. Secondary aging refers to additional deleterious structural and functional age-related changes caused by diseases and lifestyle factors. Secondary aging can exacerbate deficits in mitochondrial function and muscle mass, concomitant with the development of skeletal muscle insulin resistance. Exercise opposes deleterious effects of secondary aging by preventing the decline in mitochondrial respiration, mitigating aging-related loss of muscle mass and enhancing insulin sensitivity. This review focuses on mechanisms by which exercise promotes "healthy aging" by inducing modifications in skeletal muscle.

Original language	English
Journal	Cell Metabolism
Volume	23
Issue number	6
Pages (from-to)	1034-47
Number of pages	14
ISSN	1550-4131
DOIs	https://doi.org/10.1016/j.cmet.2016.05.007
Publication status	Published - 14 Jun 2016

Keywords

Journal Article
Review

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10.1016/j.cmet.2016.05.007

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AU - Hepple, Russell T

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AU - Zierath, Juleen R

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Y1 - 2016/6/14

N2 - Primary aging is the progressive and inevitable process of bodily deterioration during adulthood. In skeletal muscle, primary aging causes defective mitochondrial energetics and reduced muscle mass. Secondary aging refers to additional deleterious structural and functional age-related changes caused by diseases and lifestyle factors. Secondary aging can exacerbate deficits in mitochondrial function and muscle mass, concomitant with the development of skeletal muscle insulin resistance. Exercise opposes deleterious effects of secondary aging by preventing the decline in mitochondrial respiration, mitigating aging-related loss of muscle mass and enhancing insulin sensitivity. This review focuses on mechanisms by which exercise promotes "healthy aging" by inducing modifications in skeletal muscle.

AB - Primary aging is the progressive and inevitable process of bodily deterioration during adulthood. In skeletal muscle, primary aging causes defective mitochondrial energetics and reduced muscle mass. Secondary aging refers to additional deleterious structural and functional age-related changes caused by diseases and lifestyle factors. Secondary aging can exacerbate deficits in mitochondrial function and muscle mass, concomitant with the development of skeletal muscle insulin resistance. Exercise opposes deleterious effects of secondary aging by preventing the decline in mitochondrial respiration, mitigating aging-related loss of muscle mass and enhancing insulin sensitivity. This review focuses on mechanisms by which exercise promotes "healthy aging" by inducing modifications in skeletal muscle.

KW - Journal Article

KW - Review

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DO - 10.1016/j.cmet.2016.05.007

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JO - Cell Metabolism

JF - Cell Metabolism

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ER -

Exercise Promotes Healthy Aging of Skeletal Muscle

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