Exercise Promotes Healthy Aging of Skeletal Muscle

Gregory D Cartee; Russell T Hepple; Marcas M Bamman; Juleen R Zierath

doi:10.1016/j.cmet.2016.05.007

Exercise Promotes Healthy Aging of Skeletal Muscle

Gregory D Cartee, Russell T Hepple, Marcas M Bamman, Juleen R Zierath

166 Citationer (Scopus)

Abstract

Primary aging is the progressive and inevitable process of bodily deterioration during adulthood. In skeletal muscle, primary aging causes defective mitochondrial energetics and reduced muscle mass. Secondary aging refers to additional deleterious structural and functional age-related changes caused by diseases and lifestyle factors. Secondary aging can exacerbate deficits in mitochondrial function and muscle mass, concomitant with the development of skeletal muscle insulin resistance. Exercise opposes deleterious effects of secondary aging by preventing the decline in mitochondrial respiration, mitigating aging-related loss of muscle mass and enhancing insulin sensitivity. This review focuses on mechanisms by which exercise promotes "healthy aging" by inducing modifications in skeletal muscle.

Originalsprog	Engelsk
Tidsskrift	Cell Metabolism
Vol/bind	23
Udgave nummer	6
Sider (fra-til)	1034-47
Antal sider	14
ISSN	1550-4131
DOI	https://doi.org/10.1016/j.cmet.2016.05.007
Status	Udgivet - 14 jun. 2016

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10.1016/j.cmet.2016.05.007

http://www.cell.com/article/S155041311630225X/pdf

Citationsformater

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abstract = "Primary aging is the progressive and inevitable process of bodily deterioration during adulthood. In skeletal muscle, primary aging causes defective mitochondrial energetics and reduced muscle mass. Secondary aging refers to additional deleterious structural and functional age-related changes caused by diseases and lifestyle factors. Secondary aging can exacerbate deficits in mitochondrial function and muscle mass, concomitant with the development of skeletal muscle insulin resistance. Exercise opposes deleterious effects of secondary aging by preventing the decline in mitochondrial respiration, mitigating aging-related loss of muscle mass and enhancing insulin sensitivity. This review focuses on mechanisms by which exercise promotes {"}healthy aging{"} by inducing modifications in skeletal muscle.",

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AU - Cartee, Gregory D

AU - Hepple, Russell T

AU - Bamman, Marcas M

AU - Zierath, Juleen R

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Y1 - 2016/6/14

N2 - Primary aging is the progressive and inevitable process of bodily deterioration during adulthood. In skeletal muscle, primary aging causes defective mitochondrial energetics and reduced muscle mass. Secondary aging refers to additional deleterious structural and functional age-related changes caused by diseases and lifestyle factors. Secondary aging can exacerbate deficits in mitochondrial function and muscle mass, concomitant with the development of skeletal muscle insulin resistance. Exercise opposes deleterious effects of secondary aging by preventing the decline in mitochondrial respiration, mitigating aging-related loss of muscle mass and enhancing insulin sensitivity. This review focuses on mechanisms by which exercise promotes "healthy aging" by inducing modifications in skeletal muscle.

AB - Primary aging is the progressive and inevitable process of bodily deterioration during adulthood. In skeletal muscle, primary aging causes defective mitochondrial energetics and reduced muscle mass. Secondary aging refers to additional deleterious structural and functional age-related changes caused by diseases and lifestyle factors. Secondary aging can exacerbate deficits in mitochondrial function and muscle mass, concomitant with the development of skeletal muscle insulin resistance. Exercise opposes deleterious effects of secondary aging by preventing the decline in mitochondrial respiration, mitigating aging-related loss of muscle mass and enhancing insulin sensitivity. This review focuses on mechanisms by which exercise promotes "healthy aging" by inducing modifications in skeletal muscle.

KW - Journal Article

KW - Review

U2 - 10.1016/j.cmet.2016.05.007

DO - 10.1016/j.cmet.2016.05.007

M3 - Journal article

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SN - 1550-4131

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SP - 1034

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JO - Cell Metabolism

JF - Cell Metabolism

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ER -

Exercise Promotes Healthy Aging of Skeletal Muscle

Abstract

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