Exercise and cancer: from “healthy” to “therapeutic”?

Manja Idorn; Per thor Straten

doi:10.1007/s00262-017-1985-z

Exercise and cancer: from “healthy” to “therapeutic”?

Manja Idorn, Per thor Straten^*

^*Corresponding author for this work

30 Citations (Scopus)

89 Downloads (Pure)

Abstract

Exercise improves functional capacity and patient-reported outcomes across a range of cancer diagnoses. The mechanisms behind this protection have been largely unknown, but exercise-mediated changes in body composition, sex hormone levels, systemic inflammation, and immune cell function have been suggested to play a role. We recently demonstrated that voluntary exercise leads to an influx of immune cells in tumors, and a more than 60% reduction in tumor incidence and growth across several mouse models. Given the common mechanisms of immune cell mobilization in mouse and man during exercise, we hypothesize that this link between exercise and the immune system can be exploited in cancer therapy in particular in combination with immunotherapy. Thus, we believe that exercise may not just be “healthy” but may in fact be therapeutic.

Original language	English
Journal	Cancer Immunology, Immunotherapy
Volume	66
Issue number	5
Pages (from-to)	667-671
Number of pages	5
ISSN	0340-7004
DOIs	https://doi.org/10.1007/s00262-017-1985-z
Publication status	Published - May 2017

Keywords

CIMT 2016
Combination treatment
Exercise
Immune cell mobilization
NK cells
Tumor infiltration

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1007/s00262-017-1985-zLicence: CC BY

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title = "Exercise and cancer: from “healthy” to “therapeutic”?",

abstract = "Exercise improves functional capacity and patient-reported outcomes across a range of cancer diagnoses. The mechanisms behind this protection have been largely unknown, but exercise-mediated changes in body composition, sex hormone levels, systemic inflammation, and immune cell function have been suggested to play a role. We recently demonstrated that voluntary exercise leads to an influx of immune cells in tumors, and a more than 60% reduction in tumor incidence and growth across several mouse models. Given the common mechanisms of immune cell mobilization in mouse and man during exercise, we hypothesize that this link between exercise and the immune system can be exploited in cancer therapy in particular in combination with immunotherapy. Thus, we believe that exercise may not just be “healthy” but may in fact be therapeutic.",

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AB - Exercise improves functional capacity and patient-reported outcomes across a range of cancer diagnoses. The mechanisms behind this protection have been largely unknown, but exercise-mediated changes in body composition, sex hormone levels, systemic inflammation, and immune cell function have been suggested to play a role. We recently demonstrated that voluntary exercise leads to an influx of immune cells in tumors, and a more than 60% reduction in tumor incidence and growth across several mouse models. Given the common mechanisms of immune cell mobilization in mouse and man during exercise, we hypothesize that this link between exercise and the immune system can be exploited in cancer therapy in particular in combination with immunotherapy. Thus, we believe that exercise may not just be “healthy” but may in fact be therapeutic.

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KW - Combination treatment

KW - Exercise

KW - Immune cell mobilization

KW - NK cells

KW - Tumor infiltration

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ER -

Exercise and cancer: from “healthy” to “therapeutic”?

Abstract

Keywords

UN SDGs

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