Exercise and cancer: from “healthy” to “therapeutic”?

Manja Idorn; Per thor Straten

doi:10.1007/s00262-017-1985-z

Exercise and cancer: from “healthy” to “therapeutic”?

Manja Idorn, Per thor Straten^*

^*Corresponding author af dette arbejde

30 Citationer (Scopus)

89 Downloads (Pure)

Abstract

Exercise improves functional capacity and patient-reported outcomes across a range of cancer diagnoses. The mechanisms behind this protection have been largely unknown, but exercise-mediated changes in body composition, sex hormone levels, systemic inflammation, and immune cell function have been suggested to play a role. We recently demonstrated that voluntary exercise leads to an influx of immune cells in tumors, and a more than 60% reduction in tumor incidence and growth across several mouse models. Given the common mechanisms of immune cell mobilization in mouse and man during exercise, we hypothesize that this link between exercise and the immune system can be exploited in cancer therapy in particular in combination with immunotherapy. Thus, we believe that exercise may not just be “healthy” but may in fact be therapeutic.

Originalsprog	Engelsk
Tidsskrift	Cancer Immunology, Immunotherapy
Vol/bind	66
Udgave nummer	5
Sider (fra-til)	667-671
Antal sider	5
ISSN	0340-7004
DOI	https://doi.org/10.1007/s00262-017-1985-z
Status	Udgivet - maj 2017

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10.1007/s00262-017-1985-zLicens: CC BY

Exercise and cancer: from “healthy” to “therapeutic”?Forlagets udgivne version, 631 KBLicens: CC BY

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abstract = "Exercise improves functional capacity and patient-reported outcomes across a range of cancer diagnoses. The mechanisms behind this protection have been largely unknown, but exercise-mediated changes in body composition, sex hormone levels, systemic inflammation, and immune cell function have been suggested to play a role. We recently demonstrated that voluntary exercise leads to an influx of immune cells in tumors, and a more than 60% reduction in tumor incidence and growth across several mouse models. Given the common mechanisms of immune cell mobilization in mouse and man during exercise, we hypothesize that this link between exercise and the immune system can be exploited in cancer therapy in particular in combination with immunotherapy. Thus, we believe that exercise may not just be “healthy” but may in fact be therapeutic.",

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AU - thor Straten, Per

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N2 - Exercise improves functional capacity and patient-reported outcomes across a range of cancer diagnoses. The mechanisms behind this protection have been largely unknown, but exercise-mediated changes in body composition, sex hormone levels, systemic inflammation, and immune cell function have been suggested to play a role. We recently demonstrated that voluntary exercise leads to an influx of immune cells in tumors, and a more than 60% reduction in tumor incidence and growth across several mouse models. Given the common mechanisms of immune cell mobilization in mouse and man during exercise, we hypothesize that this link between exercise and the immune system can be exploited in cancer therapy in particular in combination with immunotherapy. Thus, we believe that exercise may not just be “healthy” but may in fact be therapeutic.

AB - Exercise improves functional capacity and patient-reported outcomes across a range of cancer diagnoses. The mechanisms behind this protection have been largely unknown, but exercise-mediated changes in body composition, sex hormone levels, systemic inflammation, and immune cell function have been suggested to play a role. We recently demonstrated that voluntary exercise leads to an influx of immune cells in tumors, and a more than 60% reduction in tumor incidence and growth across several mouse models. Given the common mechanisms of immune cell mobilization in mouse and man during exercise, we hypothesize that this link between exercise and the immune system can be exploited in cancer therapy in particular in combination with immunotherapy. Thus, we believe that exercise may not just be “healthy” but may in fact be therapeutic.

KW - CIMT 2016

KW - Combination treatment

KW - Exercise

KW - Immune cell mobilization

KW - NK cells

KW - Tumor infiltration

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JO - Cancer Immunology, Immunotherapy

JF - Cancer Immunology, Immunotherapy

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ER -

Exercise and cancer: from “healthy” to “therapeutic”?

Abstract

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