Excitatory amino acid transporters: recent insights into molecular mechanisms, novel modes of modulation and new therapeutic possibilities

Anders A. Jensen; Christoph Fahlke; Walden Emil Bjørn-Yoshimoto; Lennart Bunch

doi:10.1016/j.coph.2014.10.008

Excitatory amino acid transporters: recent insights into molecular mechanisms, novel modes of modulation and new therapeutic possibilities

Anders A. Jensen, Christoph Fahlke, Walden Emil Bjørn-Yoshimoto, Lennart Bunch

62 Citations (Scopus)

Abstract

The five excitatory amino acid transporters (EAAT1–5) mediating the synaptic uptake of the major excitatory neurotransmitter glutamate are differently expressed throughout the CNS and at the synaptic level. Although EAATs are crucial for normal excitatory neurotransmission, explorations into the physiological functions mediated by the different transporter subtypes and their respective therapeutic potential have so far been sparse, in no small part due to the limited selection of pharmacological tools available. In the present update, we outline important new insights into the molecular compositions of EAATs and their intricate transport process, the novel approaches to pharmacological modulation of the transporters that have emerged, and interesting new perspectives in EAAT as drug targets proposed in recent years.

Original language	English
Journal	Current Opinion in Pharmacology
Volume	20
Pages (from-to)	116-123
Number of pages	8
ISSN	1471-4892
DOIs	https://doi.org/10.1016/j.coph.2014.10.008
Publication status	Published - Feb 2015

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Excitatory amino acid transporters: recent insights into molecular mechanisms, novel modes of modulation and new therapeutic possibilities. / Jensen, Anders A.; Fahlke, Christoph; Bjørn-Yoshimoto, Walden Emil et al.
In: Current Opinion in Pharmacology, Vol. 20, 02.2015, p. 116-123.

Research output: Contribution to journal › Journal article › Research › peer-review

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Excitatory amino acid transporters: recent insights into molecular mechanisms, novel modes of modulation and new therapeutic possibilities

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