Excitatory amino acid transporters: recent insights into molecular mechanisms, novel modes of modulation and new therapeutic possibilities

Anders A. Jensen; Christoph Fahlke; Walden Emil Bjørn-Yoshimoto; Lennart Bunch

doi:10.1016/j.coph.2014.10.008

Excitatory amino acid transporters: recent insights into molecular mechanisms, novel modes of modulation and new therapeutic possibilities

Anders A. Jensen, Christoph Fahlke, Walden Emil Bjørn-Yoshimoto, Lennart Bunch

62 Citationer (Scopus)

Abstract

The five excitatory amino acid transporters (EAAT1–5) mediating the synaptic uptake of the major excitatory neurotransmitter glutamate are differently expressed throughout the CNS and at the synaptic level. Although EAATs are crucial for normal excitatory neurotransmission, explorations into the physiological functions mediated by the different transporter subtypes and their respective therapeutic potential have so far been sparse, in no small part due to the limited selection of pharmacological tools available. In the present update, we outline important new insights into the molecular compositions of EAATs and their intricate transport process, the novel approaches to pharmacological modulation of the transporters that have emerged, and interesting new perspectives in EAAT as drug targets proposed in recent years.

Originalsprog	Engelsk
Tidsskrift	Current Opinion in Pharmacology
Vol/bind	20
Sider (fra-til)	116-123
Antal sider	8
ISSN	1471-4892
DOI	https://doi.org/10.1016/j.coph.2014.10.008
Status	Udgivet - feb. 2015

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10.1016/j.coph.2014.10.008

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abstract = "The five excitatory amino acid transporters (EAAT1–5) mediating the synaptic uptake of the major excitatory neurotransmitter glutamate are differently expressed throughout the CNS and at the synaptic level. Although EAATs are crucial for normal excitatory neurotransmission, explorations into the physiological functions mediated by the different transporter subtypes and their respective therapeutic potential have so far been sparse, in no small part due to the limited selection of pharmacological tools available. In the present update, we outline important new insights into the molecular compositions of EAATs and their intricate transport process, the novel approaches to pharmacological modulation of the transporters that have emerged, and interesting new perspectives in EAAT as drug targets proposed in recent years.",

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AU - Fahlke, Christoph

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AU - Bunch, Lennart

PY - 2015/2

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AB - The five excitatory amino acid transporters (EAAT1–5) mediating the synaptic uptake of the major excitatory neurotransmitter glutamate are differently expressed throughout the CNS and at the synaptic level. Although EAATs are crucial for normal excitatory neurotransmission, explorations into the physiological functions mediated by the different transporter subtypes and their respective therapeutic potential have so far been sparse, in no small part due to the limited selection of pharmacological tools available. In the present update, we outline important new insights into the molecular compositions of EAATs and their intricate transport process, the novel approaches to pharmacological modulation of the transporters that have emerged, and interesting new perspectives in EAAT as drug targets proposed in recent years.

U2 - 10.1016/j.coph.2014.10.008

DO - 10.1016/j.coph.2014.10.008

M3 - Journal article

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SP - 116

EP - 123

JO - Current Opinion in Pharmacology

JF - Current Opinion in Pharmacology

ER -

Excitatory amino acid transporters: recent insights into molecular mechanisms, novel modes of modulation and new therapeutic possibilities

Abstract

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