Abstract
We tested the hypothesis that variants in the gene encoding the prepropeptide YY (PYY) associate with type 2 diabetes and/or obesity. Mutation analyses of DNA from 84 patients with obesity and familial type 2 diabetes identified two polymorphisms, IVS3 + 68C>T and Arg72Thr, and one rare variant, +151C>A of PYY. The common allele of the Arg72Thr variant associated with type 2 diabetes with an allele frequency of the Arg allele of 0.667 (95% CI 0.658-0.677) among 4,639 glucose-tolerant subjects and 0.692 (0.674-0.710) among 1,326 patients with type 2 diabetes (P = 0.005, odds ratio 1.19 [95% CI 1.05-1.35]). The same polymorphism associated with overweight (25 <or = BMI <30 kg/m2) (P = 0.018, 1.15 [1.02-1.28]). In quantitative trait analyses of a population-based sample of 6,022 subjects, the Arg allele was associated with an increased plasma glucose level 2 h after an oral glucose tolerance test (OGTT) (P = 0.03), an increased area under the curve for the post-OGTT plasma glucose level (P = 0.03), and a lower insulinogenic index (P = 0.01). In conclusion, the common Arg allele of the PYY Arg72Thr variant modestly associates with type 2 diabetes and with type 2 diabetes-related quantitative traits.
| Original language | English |
|---|---|
| Journal | Diabetes |
| Volume | 54 |
| Issue number | 7 |
| Pages (from-to) | 2261-5 |
| Number of pages | 5 |
| ISSN | 0012-1797 |
| Publication status | Published - 2005 |
Keywords
- Arginine
- Body Mass Index
- DNA
- DNA Mutational Analysis
- Diabetes Mellitus, Type 2
- Female
- Humans
- Male
- Obesity
- Odds Ratio
- Pedigree
- Peptide YY
- Polymorphism, Genetic
- Risk Factors
- Sequence Deletion
