Evidence of an association between genetic variation of the coactivator PGC-1beta and obesity

G Andersen; L Wegner; K Yanagisawa; C S Rose; J Lin; C Glümer; T Drivsholm; K Borch-Johnsen; T Jørgensen; T Hansen; B M Spiegelman; O Pedersen

doi:10.1136/jmg.2004.026278

Evidence of an association between genetic variation of the coactivator PGC-1beta and obesity

G Andersen, L Wegner, K Yanagisawa, C S Rose, J Lin, C Glümer, T Drivsholm, K Borch-Johnsen, T Jørgensen, T Hansen, B M Spiegelman, O Pedersen

49 Citations (Scopus)

Abstract

Peroxisome proliferator activated receptor-gamma coactivator-1beta (PGC-1beta) is a recently identified homologue of the tissue specific coactivator PGC-1alpha, a coactivator of transcription factors such as the peroxisome proliferators activated receptors and nuclear respiratory factors. PGC-1alpha is involved in adipogenesis, mitochondrial biogenesis, fatty acid beta oxidation, and hepatic gluconeogenesis.

Original language	English
Journal	Journal of Medical Genetics
Volume	42
Issue number	5
Pages (from-to)	402-7
Number of pages	6
ISSN	1468-6244
DOIs	https://doi.org/10.1136/jmg.2004.026278
Publication status	Published - 1 May 2005

Keywords

Aged
Carrier Proteins
DNA Mutational Analysis
Denmark
Diabetes Mellitus, Type 2
Gene Frequency
Genetic Testing
Genetic Variation
Genotype
Glucose
Humans
Linkage Disequilibrium
Middle Aged
Mutation
Obesity

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1136/jmg.2004.026278

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title = "Evidence of an association between genetic variation of the coactivator PGC-1beta and obesity",

abstract = "Peroxisome proliferator activated receptor-gamma coactivator-1beta (PGC-1beta) is a recently identified homologue of the tissue specific coactivator PGC-1alpha, a coactivator of transcription factors such as the peroxisome proliferators activated receptors and nuclear respiratory factors. PGC-1alpha is involved in adipogenesis, mitochondrial biogenesis, fatty acid beta oxidation, and hepatic gluconeogenesis.",

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language = "English",

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T1 - Evidence of an association between genetic variation of the coactivator PGC-1beta and obesity

AU - Andersen, G

AU - Wegner, L

AU - Yanagisawa, K

AU - Rose, C S

AU - Lin, J

AU - Glümer, C

AU - Drivsholm, T

AU - Borch-Johnsen, K

AU - Jørgensen, T

AU - Hansen, T

AU - Spiegelman, B M

AU - Pedersen, O

PY - 2005/5/1

Y1 - 2005/5/1

N2 - Peroxisome proliferator activated receptor-gamma coactivator-1beta (PGC-1beta) is a recently identified homologue of the tissue specific coactivator PGC-1alpha, a coactivator of transcription factors such as the peroxisome proliferators activated receptors and nuclear respiratory factors. PGC-1alpha is involved in adipogenesis, mitochondrial biogenesis, fatty acid beta oxidation, and hepatic gluconeogenesis.

AB - Peroxisome proliferator activated receptor-gamma coactivator-1beta (PGC-1beta) is a recently identified homologue of the tissue specific coactivator PGC-1alpha, a coactivator of transcription factors such as the peroxisome proliferators activated receptors and nuclear respiratory factors. PGC-1alpha is involved in adipogenesis, mitochondrial biogenesis, fatty acid beta oxidation, and hepatic gluconeogenesis.

KW - Aged

KW - Carrier Proteins

KW - DNA Mutational Analysis

KW - Denmark

KW - Diabetes Mellitus, Type 2

KW - Gene Frequency

KW - Genetic Testing

KW - Genetic Variation

KW - Genotype

KW - Glucose

KW - Humans

KW - Linkage Disequilibrium

KW - Middle Aged

KW - Mutation

KW - Obesity

U2 - 10.1136/jmg.2004.026278

DO - 10.1136/jmg.2004.026278

M3 - Journal article

C2 - 15863669

SN - 1468-6244

VL - 42

SP - 402

EP - 407

JO - Journal of Medical Genetics

JF - Journal of Medical Genetics

IS - 5

ER -

Evidence of an association between genetic variation of the coactivator PGC-1beta and obesity

Abstract

Keywords

UN SDGs

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