Evidence of an association between genetic variation of the coactivator PGC-1beta and obesity

TY - JOUR

T1 - Evidence of an association between genetic variation of the coactivator PGC-1beta and obesity

AU - Andersen, G

AU - Wegner, L

AU - Yanagisawa, K

AU - Rose, C S

AU - Lin, J

AU - Glümer, C

AU - Drivsholm, T

AU - Borch-Johnsen, K

AU - Jørgensen, T

AU - Hansen, T

AU - Spiegelman, B M

AU - Pedersen, O

PY - 2005/5/1

Y1 - 2005/5/1

N2 - Peroxisome proliferator activated receptor-gamma coactivator-1beta (PGC-1beta) is a recently identified homologue of the tissue specific coactivator PGC-1alpha, a coactivator of transcription factors such as the peroxisome proliferators activated receptors and nuclear respiratory factors. PGC-1alpha is involved in adipogenesis, mitochondrial biogenesis, fatty acid beta oxidation, and hepatic gluconeogenesis.

AB - Peroxisome proliferator activated receptor-gamma coactivator-1beta (PGC-1beta) is a recently identified homologue of the tissue specific coactivator PGC-1alpha, a coactivator of transcription factors such as the peroxisome proliferators activated receptors and nuclear respiratory factors. PGC-1alpha is involved in adipogenesis, mitochondrial biogenesis, fatty acid beta oxidation, and hepatic gluconeogenesis.

KW - Aged

KW - Carrier Proteins

KW - DNA Mutational Analysis

KW - Denmark

KW - Diabetes Mellitus, Type 2

KW - Gene Frequency

KW - Genetic Testing

KW - Genetic Variation

KW - Genotype

KW - Glucose

KW - Humans

KW - Linkage Disequilibrium

KW - Middle Aged

KW - Mutation

KW - Obesity

U2 - 10.1136/jmg.2004.026278

DO - 10.1136/jmg.2004.026278

M3 - Journal article

C2 - 15863669

SN - 0022-2593

VL - 42

SP - 402

EP - 407

JO - Journal of Medical Genetics

JF - Journal of Medical Genetics

IS - 5

ER -