European multicenter study on antimicrobial resistance in bacteria isolated from companion animal urinary tract infections

Cátia Marques; Luís Telo Gama; Adriana Belas; Karin Bergström; Stéphanie Beurlet; Alexandra Briend-Marchal; Els M Broens; Marta Costa; Delphine Criel; Peter Damborg; Marloes A M van Dijk; Astrid M van Dongen; Roswitha Dorsch; Carmen Martin Espada; Bernhard Gerber; Maria Kritsepi-Konstantinou; Igor Loncaric; Domenico Mion; Dusan Misic; Rebeca Movilla; Gudrun Overesch; Vincent Perreten; Xavier Roura; Joachim Steenbergen; Dorina Timofte; Georg Wolf; Renato Giulio Zanoni; Sarah Schmitt; Luca Guardabassi; Constança Pomba

doi:10.1186/s12917-016-0840-3

European multicenter study on antimicrobial resistance in bacteria isolated from companion animal urinary tract infections

Cátia Marques, Luís Telo Gama, Adriana Belas, Karin Bergström, Stéphanie Beurlet, Alexandra Briend-Marchal, Els M Broens, Marta Costa, Delphine Criel, Peter Damborg, Marloes A M van Dijk, Astrid M van Dongen, Roswitha Dorsch, Carmen Martin Espada, Bernhard Gerber, Maria Kritsepi-Konstantinou, Igor Loncaric, Domenico Mion, Dusan Misic, Rebeca MovillaGudrun Overesch, Vincent Perreten, Xavier Roura, Joachim Steenbergen, Dorina Timofte, Georg Wolf, Renato Giulio Zanoni, Sarah Schmitt, Luca Guardabassi, Constança Pomba

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Abstract

BACKGROUND: There is a growing concern regarding the increase of antimicrobial resistant bacteria in companion animals. Yet, there are no studies comparing the resistance levels of these organisms in European countries. The aim of this study was to investigate geographical and temporal trends of antimicrobial resistant bacteria causing urinary tract infection (UTI) in companion animals in Europe. The antimicrobial susceptibility of 22 256 bacteria isolated from dogs and cats with UTI was determined. Samples were collected between 2008 and 2013 from 16 laboratories of 14 European countries. The prevalence of antimicrobial resistance of the most common bacteria was determined for each country individually in the years 2012-2013 and temporal trends of bacteria resistance were established by logistic regression.

RESULTS: The aetiology of uropathogenic bacteria differed between dogs and cats. For all bacterial species, Southern countries generally presented higher levels of antimicrobial resistance compared to Northern countries. Multidrug-resistant Escherichia coli were found to be more prevalent in Southern countries. During the study period, the level of fluoroquinolone-resistant E. coli isolated in Belgium, Denmark, France and the Netherlands decreased significantly. A temporal increase in resistance to amoxicillin-clavulanate and gentamicin was observed among E. coli isolates from the Netherlands and Switzerland, respectively. Other country-specific temporal increases were observed for fluoroquinolone-resistant Proteus spp. isolated from companion animals from Belgium.

CONCLUSIONS: This work brings new insights into the current status of antimicrobial resistance in bacteria isolated from companion animals with UTI in Europe and reinforces the need for strategies aiming to reduce resistance.

Original language	English
Article number	213
Journal	BMC Veterinary Research
Volume	12
Number of pages	17
ISSN	1746-6148
DOIs	https://doi.org/10.1186/s12917-016-0840-3
Publication status	Published - 22 Sept 2016

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European multicenter study on antimicrobial resistance in bacteria isolated from companion animal urinary tract infectionsFinal published version, 8.46 MBLicence: CC BY

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Marques, C., Gama, L. T., Belas, A., Bergström, K., Beurlet, S., Briend-Marchal, A., Broens, E. M., Costa, M., Criel, D., Damborg, P., van Dijk, M. A. M., van Dongen, A. M., Dorsch, R., Espada, C. M., Gerber, B., Kritsepi-Konstantinou, M., Loncaric, I., Mion, D., Misic, D., ... Pomba, C. (2016). European multicenter study on antimicrobial resistance in bacteria isolated from companion animal urinary tract infections. BMC Veterinary Research, 12, Article 213. https://doi.org/10.1186/s12917-016-0840-3

Marques, C, Gama, LT, Belas, A, Bergström, K, Beurlet, S, Briend-Marchal, A, Broens, EM, Costa, M, Criel, D, Damborg, P, van Dijk, MAM, van Dongen, AM, Dorsch, R, Espada, CM, Gerber, B, Kritsepi-Konstantinou, M, Loncaric, I, Mion, D, Misic, D, Movilla, R, Overesch, G, Perreten, V, Roura, X, Steenbergen, J, Timofte, D, Wolf, G, Zanoni, RG, Schmitt, S, Guardabassi, L & Pomba, C 2016, 'European multicenter study on antimicrobial resistance in bacteria isolated from companion animal urinary tract infections', BMC Veterinary Research, vol. 12, 213. https://doi.org/10.1186/s12917-016-0840-3

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title = "European multicenter study on antimicrobial resistance in bacteria isolated from companion animal urinary tract infections",

abstract = "BACKGROUND: There is a growing concern regarding the increase of antimicrobial resistant bacteria in companion animals. Yet, there are no studies comparing the resistance levels of these organisms in European countries. The aim of this study was to investigate geographical and temporal trends of antimicrobial resistant bacteria causing urinary tract infection (UTI) in companion animals in Europe. The antimicrobial susceptibility of 22 256 bacteria isolated from dogs and cats with UTI was determined. Samples were collected between 2008 and 2013 from 16 laboratories of 14 European countries. The prevalence of antimicrobial resistance of the most common bacteria was determined for each country individually in the years 2012-2013 and temporal trends of bacteria resistance were established by logistic regression.RESULTS: The aetiology of uropathogenic bacteria differed between dogs and cats. For all bacterial species, Southern countries generally presented higher levels of antimicrobial resistance compared to Northern countries. Multidrug-resistant Escherichia coli were found to be more prevalent in Southern countries. During the study period, the level of fluoroquinolone-resistant E. coli isolated in Belgium, Denmark, France and the Netherlands decreased significantly. A temporal increase in resistance to amoxicillin-clavulanate and gentamicin was observed among E. coli isolates from the Netherlands and Switzerland, respectively. Other country-specific temporal increases were observed for fluoroquinolone-resistant Proteus spp. isolated from companion animals from Belgium.CONCLUSIONS: This work brings new insights into the current status of antimicrobial resistance in bacteria isolated from companion animals with UTI in Europe and reinforces the need for strategies aiming to reduce resistance.",

author = "C{\'a}tia Marques and Gama, {Lu{\'i}s Telo} and Adriana Belas and Karin Bergstr{\"o}m and St{\'e}phanie Beurlet and Alexandra Briend-Marchal and Broens, {Els M} and Marta Costa and Delphine Criel and Peter Damborg and {van Dijk}, {Marloes A M} and {van Dongen}, {Astrid M} and Roswitha Dorsch and Espada, {Carmen Martin} and Bernhard Gerber and Maria Kritsepi-Konstantinou and Igor Loncaric and Domenico Mion and Dusan Misic and Rebeca Movilla and Gudrun Overesch and Vincent Perreten and Xavier Roura and Joachim Steenbergen and Dorina Timofte and Georg Wolf and Zanoni, {Renato Giulio} and Sarah Schmitt and Luca Guardabassi and Constan{\c c}a Pomba",

year = "2016",

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doi = "10.1186/s12917-016-0840-3",

language = "English",

volume = "12",

journal = "BMC Veterinary Research",

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TY - JOUR

T1 - European multicenter study on antimicrobial resistance in bacteria isolated from companion animal urinary tract infections

AU - Marques, Cátia

AU - Gama, Luís Telo

AU - Belas, Adriana

AU - Bergström, Karin

AU - Beurlet, Stéphanie

AU - Briend-Marchal, Alexandra

AU - Broens, Els M

AU - Costa, Marta

AU - Criel, Delphine

AU - Damborg, Peter

AU - van Dijk, Marloes A M

AU - van Dongen, Astrid M

AU - Dorsch, Roswitha

AU - Espada, Carmen Martin

AU - Gerber, Bernhard

AU - Kritsepi-Konstantinou, Maria

AU - Loncaric, Igor

AU - Mion, Domenico

AU - Misic, Dusan

AU - Movilla, Rebeca

AU - Overesch, Gudrun

AU - Perreten, Vincent

AU - Roura, Xavier

AU - Steenbergen, Joachim

AU - Timofte, Dorina

AU - Wolf, Georg

AU - Zanoni, Renato Giulio

AU - Schmitt, Sarah

AU - Guardabassi, Luca

AU - Pomba, Constança

PY - 2016/9/22

Y1 - 2016/9/22

N2 - BACKGROUND: There is a growing concern regarding the increase of antimicrobial resistant bacteria in companion animals. Yet, there are no studies comparing the resistance levels of these organisms in European countries. The aim of this study was to investigate geographical and temporal trends of antimicrobial resistant bacteria causing urinary tract infection (UTI) in companion animals in Europe. The antimicrobial susceptibility of 22 256 bacteria isolated from dogs and cats with UTI was determined. Samples were collected between 2008 and 2013 from 16 laboratories of 14 European countries. The prevalence of antimicrobial resistance of the most common bacteria was determined for each country individually in the years 2012-2013 and temporal trends of bacteria resistance were established by logistic regression.RESULTS: The aetiology of uropathogenic bacteria differed between dogs and cats. For all bacterial species, Southern countries generally presented higher levels of antimicrobial resistance compared to Northern countries. Multidrug-resistant Escherichia coli were found to be more prevalent in Southern countries. During the study period, the level of fluoroquinolone-resistant E. coli isolated in Belgium, Denmark, France and the Netherlands decreased significantly. A temporal increase in resistance to amoxicillin-clavulanate and gentamicin was observed among E. coli isolates from the Netherlands and Switzerland, respectively. Other country-specific temporal increases were observed for fluoroquinolone-resistant Proteus spp. isolated from companion animals from Belgium.CONCLUSIONS: This work brings new insights into the current status of antimicrobial resistance in bacteria isolated from companion animals with UTI in Europe and reinforces the need for strategies aiming to reduce resistance.

AB - BACKGROUND: There is a growing concern regarding the increase of antimicrobial resistant bacteria in companion animals. Yet, there are no studies comparing the resistance levels of these organisms in European countries. The aim of this study was to investigate geographical and temporal trends of antimicrobial resistant bacteria causing urinary tract infection (UTI) in companion animals in Europe. The antimicrobial susceptibility of 22 256 bacteria isolated from dogs and cats with UTI was determined. Samples were collected between 2008 and 2013 from 16 laboratories of 14 European countries. The prevalence of antimicrobial resistance of the most common bacteria was determined for each country individually in the years 2012-2013 and temporal trends of bacteria resistance were established by logistic regression.RESULTS: The aetiology of uropathogenic bacteria differed between dogs and cats. For all bacterial species, Southern countries generally presented higher levels of antimicrobial resistance compared to Northern countries. Multidrug-resistant Escherichia coli were found to be more prevalent in Southern countries. During the study period, the level of fluoroquinolone-resistant E. coli isolated in Belgium, Denmark, France and the Netherlands decreased significantly. A temporal increase in resistance to amoxicillin-clavulanate and gentamicin was observed among E. coli isolates from the Netherlands and Switzerland, respectively. Other country-specific temporal increases were observed for fluoroquinolone-resistant Proteus spp. isolated from companion animals from Belgium.CONCLUSIONS: This work brings new insights into the current status of antimicrobial resistance in bacteria isolated from companion animals with UTI in Europe and reinforces the need for strategies aiming to reduce resistance.

U2 - 10.1186/s12917-016-0840-3

DO - 10.1186/s12917-016-0840-3

M3 - Journal article

C2 - 27658466

SN - 1746-6148

VL - 12

JO - BMC Veterinary Research

JF - BMC Veterinary Research

M1 - 213

ER -

European multicenter study on antimicrobial resistance in bacteria isolated from companion animal urinary tract infections

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