Etiology and pathogenesis of multiple sclerosis

Torben Lykke Sørensen; R M Ransohoff

doi:10.1055/s-2008-1040879

Etiology and pathogenesis of multiple sclerosis

Torben Lykke Sørensen, R M Ransohoff

Department of Clinical Medicine

44 Citations (Scopus)

Abstract

The cause of multiple sclerosis (MS) remains unknown despite decades of intense research. The major research disciplines that have been brought to bear on this question include genetics, epidemiology, neuropathology, immunology, and virology. Recent advances in the understanding of the inflammatory characteristics of the MS lesion may herald the development of specific and effective treatments. The goal of this research is to improve our management of a disease that remains the major cause of neurologic disability among young adults in North America and Europe.

Original language	English
Journal	Seminars in Neurology
Volume	18
Issue number	3
Pages (from-to)	287-94
Number of pages	8
ISSN	0271-8235
DOIs	https://doi.org/10.1055/s-2008-1040879
Publication status	Published - 1998

Keywords

Autoimmune Diseases
Genetic Predisposition to Disease
Humans
Inflammation
Lymphocyte Activation
Multiple Sclerosis
T-Lymphocytes

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10.1055/s-2008-1040879

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AB - The cause of multiple sclerosis (MS) remains unknown despite decades of intense research. The major research disciplines that have been brought to bear on this question include genetics, epidemiology, neuropathology, immunology, and virology. Recent advances in the understanding of the inflammatory characteristics of the MS lesion may herald the development of specific and effective treatments. The goal of this research is to improve our management of a disease that remains the major cause of neurologic disability among young adults in North America and Europe.

KW - Autoimmune Diseases

KW - Genetic Predisposition to Disease

KW - Humans

KW - Inflammation

KW - Lymphocyte Activation

KW - Multiple Sclerosis

KW - T-Lymphocytes

U2 - 10.1055/s-2008-1040879

DO - 10.1055/s-2008-1040879

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JO - Seminars in Neurology

JF - Seminars in Neurology

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Etiology and pathogenesis of multiple sclerosis

Abstract

Keywords

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