Ethnic coefficients for glomerular filtration rate estimation by the Modification of Diet in Renal Disease study equations in the Korean population

TY - JOUR

T1 - Ethnic coefficients for glomerular filtration rate estimation by the Modification of Diet in Renal Disease study equations in the Korean population

AU - Lee, Chung Sik

AU - Cha, Ran-hui

AU - Lim, Youn-Hee

AU - Kim, Ho

AU - Song, Ka Heon

AU - Gu, Namyi

AU - Yu, Kyung Sang

AU - Lim, Chun Soo

AU - Han, Jin Suk

AU - Kim, Suhnggwon

AU - Kim, Yon Su

PY - 2010/11

Y1 - 2010/11

N2 - Race and ethnicity are influential in estimating glomerular filtration rate (GFR). We aimed to find the Korean coefficients for the Modification of Diet in Renal Disease (MDRD) study equations and to obtain novel proper estimation equations. Reference GFR was measured by systemic inulin clearance. Serum creatinine (SCr) values were measured by the alkaline picrate Jaffé kinetic method, then, recalibrated to CX3 analyzer and to isotope dilution mass spectrometry (IDMS). The Korean coefficients for the 4 and 6 variable MDRD and IDMS MDRD study equations based on the SCr recalibrated to CX3 and to IDMS were 0.73989/0.74254 and 0.99096/0.9554, respectively. Coefficients for the 4 and 6 variable MDRD equations based on the SCr measured by Jaffé method were 1.09825 and 1.04334, respectively. The modified equations showed better performances than the original equations. The novel 4 variable equations for Korean based on the SCr measured and recalibrated to IDMS were 107.904×SCr(-1.009)×age(-0.02) (×0.667, if woman) and 87.832×SCr(-0.882)×age(0.01) (×0.653, if woman), respectively. Modified estimations of the MDRD and IDMS MDRD study equations with ethnic coefficients and the novel equations improve the performance of GFR estimation for the overall renal function.

AB - Race and ethnicity are influential in estimating glomerular filtration rate (GFR). We aimed to find the Korean coefficients for the Modification of Diet in Renal Disease (MDRD) study equations and to obtain novel proper estimation equations. Reference GFR was measured by systemic inulin clearance. Serum creatinine (SCr) values were measured by the alkaline picrate Jaffé kinetic method, then, recalibrated to CX3 analyzer and to isotope dilution mass spectrometry (IDMS). The Korean coefficients for the 4 and 6 variable MDRD and IDMS MDRD study equations based on the SCr recalibrated to CX3 and to IDMS were 0.73989/0.74254 and 0.99096/0.9554, respectively. Coefficients for the 4 and 6 variable MDRD equations based on the SCr measured by Jaffé method were 1.09825 and 1.04334, respectively. The modified equations showed better performances than the original equations. The novel 4 variable equations for Korean based on the SCr measured and recalibrated to IDMS were 107.904×SCr(-1.009)×age(-0.02) (×0.667, if woman) and 87.832×SCr(-0.882)×age(0.01) (×0.653, if woman), respectively. Modified estimations of the MDRD and IDMS MDRD study equations with ethnic coefficients and the novel equations improve the performance of GFR estimation for the overall renal function.

KW - Adult

KW - Aged

KW - Aged, 80 and over

KW - Algorithms

KW - Creatinine/blood

KW - Diet

KW - Female

KW - Glomerular Filtration Rate

KW - Humans

KW - Inulin/metabolism

KW - Kidney Diseases/ethnology

KW - Male

KW - Mass Spectrometry

KW - Middle Aged

KW - Republic of Korea/ethnology

U2 - 10.3346/jkms.2010.25.11.1616

DO - 10.3346/jkms.2010.25.11.1616

M3 - Journal article

C2 - 21060751

SN - 1011-8934

VL - 25

SP - 1616

EP - 1625

JO - Journal of Korean Medical Science

JF - Journal of Korean Medical Science

IS - 11

ER -