Abstract
It is investigated if recombinant human erythropoietin (rHuEPO) treatment for 15 weeks (n=8) reduces extracellular accumulation of metabolic stress markers such as lactate, H+, and K+ during incremental exhaustive exercise. After rHuEPO treatment, normalization of blood volume and composition by hemodilution preceded an additional incremental test. Group averages were calculated for an exercise intensity ∼80% of pre-rHuEPO peak power output. After rHuEPO treatment, leg lactate release to the plasma compartment was similar to before (4.3±1.6 vs 3.9±2.5mmol/min) and remained similar after hemodilution. Venous lactate concentration was higher (P<0.05) after rHuEPO treatment (7.1±1.6 vs 5.2±2.1mM). Leg H+ release to the plasma compartment after rHuEPO was similar to before (19.6±5.4 vs 17.6±6.0mmol/min) and remained similar after hemodilution. Nevertheless, venous pH was lower (P<0.05) after rHuEPO treatment (7.18±0.04 vs 7.22±0.05). Leg K+ release to the plasma compartment after rHuEPO treatment was similar to before (0.8±0.5 vs 0.7±0.7mmol/min) and remained similar after hemodilution. Additionally, venous K+ concentrations were similar after vs before rHuEPO (5.3±0.3 vs 5.1±0.4mM). In conclusion, rHuEPO does not reduce plasma accumulation of lactate, H+, and K+ at work rates corresponding to ∼80% of peak power output.
| Original language | English |
|---|---|
| Journal | Scandinavian Journal of Medicine & Science in Sports |
| Volume | 25 |
| Issue number | 6 |
| Pages (from-to) | e566-e575 |
| Number of pages | 10 |
| ISSN | 0905-7188 |
| DOIs | |
| Publication status | Published - Dec 2015 |