Erythropoietin does not reduce plasma lactate, H⁺, and K⁺ during intense exercise

TY - JOUR

T1 - Erythropoietin does not reduce plasma lactate, H+, and K+ during intense exercise

AU - Nordsborg, Nikolai Baastrup

AU - Robach, P

AU - Boushel, R

AU - Calbet, J A L

AU - Lundby, Carsten

N1 - CURIS 2015 NEXS 036

PY - 2015/12

Y1 - 2015/12

N2 - It is investigated if recombinant human erythropoietin (rHuEPO) treatment for 15 weeks (n=8) reduces extracellular accumulation of metabolic stress markers such as lactate, H+, and K+ during incremental exhaustive exercise. After rHuEPO treatment, normalization of blood volume and composition by hemodilution preceded an additional incremental test. Group averages were calculated for an exercise intensity ∼80% of pre-rHuEPO peak power output. After rHuEPO treatment, leg lactate release to the plasma compartment was similar to before (4.3±1.6 vs 3.9±2.5mmol/min) and remained similar after hemodilution. Venous lactate concentration was higher (P<0.05) after rHuEPO treatment (7.1±1.6 vs 5.2±2.1mM). Leg H+ release to the plasma compartment after rHuEPO was similar to before (19.6±5.4 vs 17.6±6.0mmol/min) and remained similar after hemodilution. Nevertheless, venous pH was lower (P<0.05) after rHuEPO treatment (7.18±0.04 vs 7.22±0.05). Leg K+ release to the plasma compartment after rHuEPO treatment was similar to before (0.8±0.5 vs 0.7±0.7mmol/min) and remained similar after hemodilution. Additionally, venous K+ concentrations were similar after vs before rHuEPO (5.3±0.3 vs 5.1±0.4mM). In conclusion, rHuEPO does not reduce plasma accumulation of lactate, H+, and K+ at work rates corresponding to ∼80% of peak power output.

AB - It is investigated if recombinant human erythropoietin (rHuEPO) treatment for 15 weeks (n=8) reduces extracellular accumulation of metabolic stress markers such as lactate, H+, and K+ during incremental exhaustive exercise. After rHuEPO treatment, normalization of blood volume and composition by hemodilution preceded an additional incremental test. Group averages were calculated for an exercise intensity ∼80% of pre-rHuEPO peak power output. After rHuEPO treatment, leg lactate release to the plasma compartment was similar to before (4.3±1.6 vs 3.9±2.5mmol/min) and remained similar after hemodilution. Venous lactate concentration was higher (P<0.05) after rHuEPO treatment (7.1±1.6 vs 5.2±2.1mM). Leg H+ release to the plasma compartment after rHuEPO was similar to before (19.6±5.4 vs 17.6±6.0mmol/min) and remained similar after hemodilution. Nevertheless, venous pH was lower (P<0.05) after rHuEPO treatment (7.18±0.04 vs 7.22±0.05). Leg K+ release to the plasma compartment after rHuEPO treatment was similar to before (0.8±0.5 vs 0.7±0.7mmol/min) and remained similar after hemodilution. Additionally, venous K+ concentrations were similar after vs before rHuEPO (5.3±0.3 vs 5.1±0.4mM). In conclusion, rHuEPO does not reduce plasma accumulation of lactate, H+, and K+ at work rates corresponding to ∼80% of peak power output.

U2 - 10.1111/sms.12374

DO - 10.1111/sms.12374

M3 - Journal article

C2 - 25556620

SN - 0905-7188

VL - 25

SP - e566-e575

JO - Scandinavian Journal of Medicine & Science in Sports

JF - Scandinavian Journal of Medicine & Science in Sports

IS - 6

ER -